Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Philipp C. Manegold"'
Autor:
Dongyun Yang, Philipp C. Manegold, Yan Ning, Young-Kwon Hong, Melissa J. LaBonte, Robert D. Ladner, A. Pohl, Peter M. Wilson, Heinz-Josef Lenz, Thomas Winder, Georg Lurje, Wu Zhang
Publikováno v:
International Journal of Cancer. 128:2038-2049
Interleukin-8 (IL-8), a chemokine with a defining CXC amino acid motif, is known to possess tumorigenic and proangiogenic properties. Overexpression of IL-8 has been detected in many human tumors, including colorectal cancer, and is associated with p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca95f292e4235db86b9b7a83856f2f54
https://doi.org/10.1002/ijc.25562
https://doi.org/10.1002/ijc.25562
Autor:
Michael G. Kahn, Philipp C. Manegold, Stephen J. Pandol, Cu Nguyen, Yongfeng Wu, Jia-Ling Teo, David P. Lin, Yi-Bu Chen, Yi Zhao, Heinz-Josef Lenz, Kaijin Wu, Yuri Genyk, Keane K. Y. Lai
Publikováno v:
Cancers
Cancers, vol 10, iss 4
Cancers, Vol 10, Iss 4, p 95 (2018)
Cancers; Volume 10; Issue 4; Pages: 95
Cancers, vol 10, iss 4
Cancers, Vol 10, Iss 4, p 95 (2018)
Cancers; Volume 10; Issue 4; Pages: 95
Background: Although canonical Wnt signaling is known to promote tumorigenesis in pancreatic ductal adenocarcinoma (PDAC), a cancer driven principally by mutant K-Ras, the detailed molecular mechanisms by which the Wnt effector β-catenin regulates s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ea7b294f7019b0a29a82f078126f17
https://doi.org/10.3390/cancers10040095
https://doi.org/10.3390/cancers10040095
Autor:
Stan G. Louie, Melissa J. LaBonte, Philipp C. Manegold, Robert D. Ladner, Will Fazzone, Peter M. Wilson, Heinz-Josef Lenz
Publikováno v:
International Journal of Cancer. 125:2957-2969
Members of the human epidermal receptor (HER) family are frequently associated with aggressive disease and poor prognosis in multiple malignancies. Lapatinib is a dual tyrosine kinase inhibitor targeting the epidermal growth factor receptor (EGFR) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::433a53c5018c1b7d3d2ccba7b2dee438
https://doi.org/10.1002/ijc.24658
https://doi.org/10.1002/ijc.24658
Publikováno v:
Advanced Drug Delivery Reviews. 61:375-380
Despite recent progress in our knowledge about the development and therapy of colorectal cancer (CRC), it still remains one of the major cancer related deaths throughout the world. With the introduction of new cytotoxic and targeting agents a signifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8d37d653e0ce56ed720361b955fa190
https://doi.org/10.1016/j.addr.2008.10.002
https://doi.org/10.1016/j.addr.2008.10.002
Publikováno v:
Targeted Oncology. 3:87-99
Epidermal growth factor receptor (EGFR) targeted therapy interferes with a molecular pathway that significantly regulates tumor growth, progression, and survival. Several clinical trials on EGFR targeted therapy revealed objective responses, and also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd9c59cf6ff5cb4dde37930f0ef9a56d
https://doi.org/10.1007/s11523-008-0077-6
https://doi.org/10.1007/s11523-008-0077-6
Publikováno v:
Blood. 101:1970-1976
Activated platelets release angiogenic growth factors and have therefore been proposed to contribute to tumor angiogenesis within a potentially prothrombotic tumor microcirculation. The aim of the study was to investigate interactions of platelets wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d37774a99dd41718668bb9b62123264
https://doi.org/10.1182/blood.v101.5.1970
https://doi.org/10.1182/blood.v101.5.1970
Autor:
Melissa J. LaBonte, Alex Yick Lun So, Chen-Yin Ou, Robert D. Ladner, Philipp C. Manegold, Daniel S. Gerke, Michael Kahn, Irina Ianculescu, Keith R. Yamamoto, Jeong Hoon Kim, Michael R. Stallcup
Aberrant activation of Wnt/β-catenin signaling, resulting in the expression of Wnt-regulated oncogenes, is recognized as a critical factor in the etiology of colorectal cancer. Occupancy of β-catenin at promoters of Wnt target genes drives transcri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::232cebaadf91a6c961f5138a47a61691
https://europepmc.org/articles/PMC3096696/
https://europepmc.org/articles/PMC3096696/
Publikováno v:
Targeting the Wnt Pathway in Cancer ISBN: 9781441980229
Wnt signaling pathways play divergent roles during development, normal homeostasis and disease. Wnt signaling is also critically important in stem cell biology. It has been demonstrated to be involved in both the proliferation and differentiation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e757cfaf8f3fd4772c81f56803dd25da
https://doi.org/10.1007/978-1-4419-8023-6_3
https://doi.org/10.1007/978-1-4419-8023-6_3
Publikováno v:
Molecular cancer therapeutics. 8(5)
Since its introduction more than 50 years ago by Heidelberger et al., the fluoropyrimidine 5-fluorouracil (5-FU) has remained the mainstay of therapeutic regimens used in the treatment of colorectal cancer and other human malignancies, with single-ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a131269bb774f8b482462e3b0bc8ff
https://pubmed.ncbi.nlm.nih.gov/19383851
https://pubmed.ncbi.nlm.nih.gov/19383851
Autor:
Philipp C. Manegold, Anne M. Schultheis, Hatim Husain, Yan Ning, Georg Lurje, Dongyun Yang, Andrew Hendifar, Heinz-Josef Lenz, Wu Zhang, A. Pohl
Publikováno v:
Pharmacogenetics and genomics. 19(2)
Purpose Identifying molecular markers for tumor recurrence is critical in successfully selecting patients with stage II colon cancer who are more likely to benefit from adjuvant chemotherapy. Interleukin 1 beta (IL1B) and interleukin 1 receptor antag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad6d0a5214e4e32d72cfa8c03030336d
https://pubmed.ncbi.nlm.nih.gov/18987561
https://pubmed.ncbi.nlm.nih.gov/18987561