The microcephaly gene Donson is essential for progenitors of cortical glutamatergic and GABAergic neurons.

Autor: Sathish Venkataramanappa, Dagmar Schütz, Friederike Saaber, Praveen Ashok Kumar, Philipp Abe, Stefan Schulz, Ralf Stumm

Publikováno v: PLoS Genetics, Vol 17, Iss 3, p e1009441 (2021)

Biallelic mutations in DONSON, an essential gene encoding for a replication fork protection factor, were linked to skeletal abnormalities and microcephaly. To better understand DONSON function in corticogenesis, we characterized Donson expression and

Externí odkaz: https://doaj.org/article/0b15ec84b3744e60a81cf511ef384c3b

Novel endoscopic scoring system for immune mediated colitis: a multicenter retrospective study of 674 patients.

Autor: Wang Y; Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Electronic address: ywang59@mdanderson.org., Abu-Sbeih H; Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; Department of Internal Medicine, University of Missouri, Kansas City, Missouri, USA., Tang T; Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; Department of General Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China., Shatila M; Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Faleck D; Gastroenterology, Hepatology and Nutrition Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Harris J; Gastroenterology, Hepatology and Nutrition Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Dougan M; Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA., Olsson-Brown A; The Clatterbridge Cancer Centre, Liverpool, UK., Johnson DB; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Shi C; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Grivas P; Department of Medicine, Division of Oncology, University of Washington, Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Diamantopoulos L; Department of Medicine, Division of Oncology, University of Washington, Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Owen DH; Division of Medical Oncology, The Ohio State University, Columbus, Ohio, USA., Cassol C; Division of Renal Pathology, The Ohio State University, Columbus, Ohio, USA., Arnold CA; Division of Gastrointestinal and Liver Pathology, The Ohio State University, Columbus, Ohio, USA., Warner DE; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA., Alva A; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA., Powell N; Royal Marsden Hospital, and Guy's and St Thomas' Hospital, London, United Kingdom., Ibraheim H; Royal Marsden Hospital, and Guy's and St Thomas' Hospital, London, United Kingdom., De Toni EN; Department of Medicine II, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany., Philipp AB; Department of Medicine II, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany., Philpott J; Center for Inflammatory Bowel Disease, Cleveland Clinic, Cleveland, Ohio, USA., Sleiman J; Center for Inflammatory Bowel Disease, Cleveland Clinic, Cleveland, Ohio, USA; Department of Gastroenterology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA., Lythgoe M; Department of Surgery and Cancer, Imperial College London, London, United Kingdom., Daniels E; Department of Oncology, Chelsea and Westminster Hospital, London, United Kingdom., Sandhu S; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Weppler AM; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Buckle A; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Pinato DJ; Department of Surgery and Cancer, Imperial College London, London, United Kingdom; Division of Oncology, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy., Thomas A; Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Qiao W; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Publikováno v: Gastrointestinal endoscopy [Gastrointest Endosc] 2024 Aug; Vol. 100 (2), pp. 273-282.e4. Date of Electronic Publication: 2024 Jan 23.

Ipilimumab and nivolumab in advanced hepatocellular carcinoma after failure of prior immune checkpoint inhibitor-based combination therapies: a multicenter retrospective study.

Autor: Roessler D; Department of Medicine II, University Hospital, LMU Munich, Marchioninistrasse 15, 81377, Munich, Bavaria, Germany. daniel.roessler@med.uni-muenchen.de.; Bavarian Cancer Research Center (BZKF), Partner site Munich, Munich, Germany. daniel.roessler@med.uni-muenchen.de., Öcal O; Department of Radiology, University Hospital, LMU Munich, Munich, Germany., Philipp AB; Department of Medicine II, University Hospital, LMU Munich, Marchioninistrasse 15, 81377, Munich, Bavaria, Germany., Markwardt D; Department of Medicine II, University Hospital, LMU Munich, Marchioninistrasse 15, 81377, Munich, Bavaria, Germany., Munker S; Department of Medicine II, University Hospital, LMU Munich, Marchioninistrasse 15, 81377, Munich, Bavaria, Germany., Mayerle J; Department of Medicine II, University Hospital, LMU Munich, Marchioninistrasse 15, 81377, Munich, Bavaria, Germany.; Bavarian Cancer Research Center (BZKF), Partner site Munich, Munich, Germany., Jochheim LS; Department for Gastroenterology and Hepatology, University Hospital Essen, University Duisburg-Essen, Duisburg, Germany., Hammer K; Department of Medicine II, University Hospital, LMU Munich, Marchioninistrasse 15, 81377, Munich, Bavaria, Germany., Lange CM; Department of Medicine II, University Hospital, LMU Munich, Marchioninistrasse 15, 81377, Munich, Bavaria, Germany.; Department for Gastroenterology and Hepatology, University Hospital Essen, University Duisburg-Essen, Duisburg, Germany., Geier A; Division of Hepatology, Department of Medicine II, University Hospital Würzburg, Würzburg, Germany., Seidensticker M; Department of Radiology, University Hospital, LMU Munich, Munich, Germany., Reiter FP; Division of Hepatology, Department of Medicine II, University Hospital Würzburg, Würzburg, Germany., De Toni EN; Department of Medicine II, University Hospital, LMU Munich, Marchioninistrasse 15, 81377, Munich, Bavaria, Germany., Ben Khaled N; Department of Medicine II, University Hospital, LMU Munich, Marchioninistrasse 15, 81377, Munich, Bavaria, Germany.; German Cancer Consortium (DKTK), Partner site Munich, Munich, Germany.

Publikováno v: Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2023 Jul; Vol. 149 (7), pp. 3065-3073. Date of Electronic Publication: 2022 Jul 21.

Efficacy and safety of immune checkpoint inhibitor rechallenge in individuals with hepatocellular carcinoma.

Autor: Scheiner B; Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.; Liver Cancer (HCC) Study Group Vienna, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria., Roessler D; Department of Medicine II, University Hospital, LMU Munich, Munich, 81377, Germany., Phen S; Department of Medicine, UT Southwestern Medical Center, Dallas TX, USA., Lim M; Department of Medicine, UT Southwestern Medical Center, Dallas TX, USA., Pomej K; Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.; Liver Cancer (HCC) Study Group Vienna, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria., Pressiani T; Medical Oncology and Hematology Unit, Humanitas Cancer Center, IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano (Milan), Italy., Cammarota A; Medical Oncology and Hematology Unit, Humanitas Cancer Center, IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano (Milan), Italy.; Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele (Milan), Italy., Fründt TW; 1. Department of Internal Medicine, Gastroenterology & Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., von Felden J; 1. Department of Internal Medicine, Gastroenterology & Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Schulze K; 1. Department of Internal Medicine, Gastroenterology & Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Himmelsbach V; Department of Gastroenterology, Hepatology and Endocrinology, University Hospital Frankfurt, Frankfurt/Main, Germany., Finkelmeier F; Department of Gastroenterology, Hepatology and Endocrinology, University Hospital Frankfurt, Frankfurt/Main, Germany., Deibel A; Department of Hepatology and Gastroenterology, University Hospital Zurich and University Zurich, Zurich, Switzerland., Siebenhüner AR; Department of Medical Oncology and Hematology, University Hospital Zurich and University Zurich, Zurich, Switzerland.; Department of Medical Oncology and Hematology, Cantonal Hospital Schaffhausen, Schaffhausen, Switzerland., Shmanko K; Department of Internal Medicine I, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., Radu P; Hepatology-Department of Biomedical Research, University of Bern, Bern, Switzerland.; Department of Visceral Surgery and Medicine, Inselspital, University of Bern, Bern, Switzerland., Schwacha-Eipper B; Department of Visceral Surgery and Medicine, Inselspital, University of Bern, Bern, Switzerland., Ebert MP; Department of Internal Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Clinical Cooperation Unit Healthy Metabolism, Center for Preventive Medicine and Digital Health Baden-Württemberg (CPDBW), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; DKFZ-Hector Cancer Institute at University Medical Center Mannheim, Mannheim, Germany., Teufel A; Clinical Cooperation Unit Healthy Metabolism, Center for Preventive Medicine and Digital Health Baden-Württemberg (CPDBW), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Department of Internal Medicine II, Division of Hepatology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Djanani A; Department of Internal Medicine I, Division of Gastroenterology, Hepatology, Endocrinology and Metabolism, Medical University of Innsbruck, Innsbruck, Austria., Hucke F; Internal Medicine and Gastroenterology (IMuG), Including Centralized Emergency Service (ZAE), Klinikum Klagenfurt am Wörthersee, Klagenfurt, Austria., Balcar L; Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.; Liver Cancer (HCC) Study Group Vienna, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria., Philipp AB; Department of Medicine II, University Hospital, LMU Munich, Munich, 81377, Germany., Hsiehchen D; Department of Medicine, UT Southwestern Medical Center, Dallas TX, USA., Venerito M; Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-Von Guericke University Hospital, 39120 Magdeburg, Germany., Sinner F; Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-Von Guericke University Hospital, 39120 Magdeburg, Germany., Trauner M; Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria., D'Alessio A; Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele (Milan), Italy.; Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK., Fulgenzi CAM; Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK.; Department of Medical Oncology, University Campus Bio-Medico of Rome, Italy., Pinato DJ; Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK.; Division of Oncology, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy., Peck-Radosavljevic M; Internal Medicine and Gastroenterology (IMuG), Including Centralized Emergency Service (ZAE), Klinikum Klagenfurt am Wörthersee, Klagenfurt, Austria., Dufour JF; Hepatology-Department of Biomedical Research, University of Bern, Bern, Switzerland., Weinmann A; Department of Internal Medicine I, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., Kremer AE; Department of Hepatology and Gastroenterology, University Hospital Zurich and University Zurich, Zurich, Switzerland.; Department of Medicine 1, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany., Singal AG; Department of Medicine, UT Southwestern Medical Center, Dallas TX, USA., De Toni EN; Department of Medicine II, University Hospital, LMU Munich, Munich, 81377, Germany., Rimassa L; Medical Oncology and Hematology Unit, Humanitas Cancer Center, IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano (Milan), Italy.; Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele (Milan), Italy., Pinter M; Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.; Liver Cancer (HCC) Study Group Vienna, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.

Publikováno v: JHEP reports : innovation in hepatology [JHEP Rep] 2022 Oct 27; Vol. 5 (1), pp. 100620. Date of Electronic Publication: 2022 Oct 27 (Print Publication: 2023).

High rate of complete histopathological response in hepatocellular carcinoma patients after combined transarterial chemoembolization and stereotactic body radiation therapy.

Autor: Bauer U; Internal Medicine II, Klinikum rechts der Isar, Technical University of Munich, Munich 81675, Germany., Gerum S; Department of Radiotherapy and Radiation Oncology, University of Salzburg, Salzburg 5020, Austria.; Department of Radiation Oncology, University Hospital of Munich, Campus Großhadern, LMU Munich, Munich 81377, Germany., Roeder F; Department of Radiotherapy and Radiation Oncology, University of Salzburg, Salzburg 5020, Austria.; Department of Radiation Oncology, University Hospital of Munich, Campus Großhadern, LMU Munich, Munich 81377, Germany., Münch S; Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich 81675, Germany., Combs SE; Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich 81675, Germany., Philipp AB; Department of Medicine II, Liver Centre, University Hospital, LMU Munich, Munich 81377, Germany., De Toni EN; Department of Medicine II, Liver Centre, University Hospital, LMU Munich, Munich 81377, Germany., Kirstein MM; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover 30625, Germany., Vogel A; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover 30625, Germany., Mogler C; Institute of Pathology, Technical University of Munich, Munich 81675, Germany., Haller B; Institute of Medical Informatics, Statistics and Epidemiology, Klinikum rechts der Isar, Technical University of Munich, Munich 81675, Germany., Neumann J; Institute of Pathology, Faculty of Medicine, University Hospital of Munich, Munich 81377, Germany., Braren RF; Institute of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, Munich 81675, Germany., Makowski MR; Institute of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, Munich 81675, Germany., Paprottka P; Institute of Diagnostic and Interventional Radiology, Section for Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, Munich 81675, Germany., Guba M; Institute of Diagnostic and Interventional Radiology, Section for Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, Munich 81675, Germany., Geisler F; Internal Medicine II, Klinikum rechts der Isar, Technical University of Munich, Munich 81675, Germany., Schmid RM; Internal Medicine II, Klinikum rechts der Isar, Technical University of Munich, Munich 81675, Germany., Umgelter A; Internal Medicine II, Klinikum rechts der Isar, Technical University of Munich, Munich 81675, Germany.; Emergency Department, Vivantes hospital group, Humboldt hospital, Berlin 13509, Germany., Ehmer U; Internal Medicine II, Klinikum rechts der Isar, Technical University of Munich, Munich 81675, Germany.

Publikováno v: World journal of gastroenterology [World J Gastroenterol] 2021 Jun 28; Vol. 27 (24), pp. 3630-3642.