Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Philipp A. M. Schmidpeter"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract The signaling lipid phosphatidylinositol-4,5-bisphosphate (PIP2) regulates many ion channels. It inhibits eukaryotic cyclic nucleotide-gated (CNG) channels while activating their relatives, the hyperpolarization-activated and cyclic nucleoti
Externí odkaz:
https://doaj.org/article/12e792ed604a43c2a3ec56fd0d939e1f
Autor:
Philipp A. M. Schmidpeter, John T. Petroff, Leila Khajoueinejad, Aboubacar Wague, Cheryl Frankfater, Wayland W. L. Cheng, Crina M. Nimigean, Paul M. Riegelhaupt
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Tandem pore (K2P) potassium channels set the cellular resting membrane potential in tissues throughout the body. Here, authors show how the composition of phospholipid within the bilayer may directly alter gating in this family of ion channels.
Externí odkaz:
https://doaj.org/article/c11664e1beb14494880bdba7127595cd
Autor:
Xiaolong Gao, Philipp A. M. Schmidpeter, Vladimir Berka, Ryan J. Durham, Chen Fan, Vasanthi Jayaraman, Crina M. Nimigean
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Visualizing conformational changes during ion channel gating is crucial to understand their regulation. Here, Gao et al. capture multiple gating intermediates in a CNG channel as well as subtle, lateral voltage sensor movements necessary for channel
Externí odkaz:
https://doaj.org/article/af4d9d2c2bc148cca9a11f009df54393
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
SthK, a cyclic nucleotide-gated ion channel from Spirochaeta thermophila activates slowly upon cAMP increase. Here, authors investigate cAMP-induced activation in purified SthK channels using stopped-flow assays and enzymatic catalysis and reveal tha
Externí odkaz:
https://doaj.org/article/472b03d2ec91449c83984880c8a21003
Autor:
Jakob Andersson, David Kleinheinz, Ulrich Ramach, Nikolaus Kiesenhofer, Alex Ashenden, Markus Valtiner, Stephen Holt, Ingo Koeper, Philipp A. M. Schmidpeter, Wolfgang Knoll
Publikováno v:
The Journal of Physical Chemistry B. 127:3641-3650
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18cae5c51070e329e1e0a72c48f4545b
https://doi.org/10.1021/acs.jpcb.2c07252
https://doi.org/10.1021/acs.jpcb.2c07252
Autor:
Yangang Pan, Emmi Pohjolainen, Philipp A. M. Schmidpeter, Andrea C. Vaiana, Crina M. Nimigean, Helmut Grubmüller, Simon Scheuring
Publikováno v:
Nat Struct Mol Biol
Cyclic nucleotide-gated ion channels are crucial in many physiological processes such as vision and pacemaking in the heart. SthK is a prokaryotic homolog with high sequence and structure similarities to hyperpolarization-activated and cyclic nucleot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae132cd3c63c43229d485133622a680
https://doi.org/10.1038/s41594-023-00955-3
https://doi.org/10.1038/s41594-023-00955-3
Publikováno v:
Methods in Enzymology ISBN: 9780323853743
Methods Enzymol
Methods Enzymol
Recent developments in cryogenic electron microscopy (cryo-EM) led to an exponential increase in high-resolution structures of membrane proteins, and in particular ion channels. However, structures alone can only provide limited information about the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9683d2bd3d3c0adf45ca54352e6533f
https://doi.org/10.1016/bs.mie.2021.02.016
https://doi.org/10.1016/bs.mie.2021.02.016
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications, 11(1):6401. Nature Publishing Group
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications, 11(1):6401. Nature Publishing Group
SthK, a cyclic nucleotide-modulated ion channel from Spirochaeta thermophila, activates slowly upon cAMP increase. This is reminiscent of the slow, cAMP-induced activation reported for the hyperpolarization-activated and cyclic nucleotide-gated chann
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9b1e0257d9cb6887f110ed6d8995eab
https://doi.org/10.1038/s41467-020-20104-4
https://doi.org/10.1038/s41467-020-20104-4
Publikováno v:
Methods in Molecular Biology ISBN: 9781071603727
Methods Mol Biol
Methods Mol Biol
Integral membrane proteins historically have been challenging targets for biophysical research due to their low solubility in aqueous solution. Their importance for chemical and electrical signaling between cells, however, makes them fascinating targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2788e8cfcfdbda51b8f7e64f4950d8d0
https://doi.org/10.1007/978-1-0716-0373-4_14
https://doi.org/10.1007/978-1-0716-0373-4_14
Autor:
Jan Rheinberger, Crina M. Nimigean, Vikrant Uphadyay, Philipp A. M. Schmidpeter, Xiaolong Gao
Publikováno v:
The Journal of General Physiology
Journal of general physiology, 150(6), 821-834
Journal of general physiology, 150(6), 821-834
SthK is a bacterial cyclic nucleotide–gated ion channel from Spirochaeta thermophila. By optimizing the expression and purification of SthK, Schmidpeter et al. show that cAMP and cGMP bind to the channel with similar affinity but activate it with d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7800a91d508cab2e49f77cb934517b55
https://research.rug.nl/en/publications/50c51515-e25b-4f7e-83a2-db509f90bed7
https://research.rug.nl/en/publications/50c51515-e25b-4f7e-83a2-db509f90bed7