Zobrazeno 1 - 10
of 246
pro vyhledávání: '"Philipp A, Lang"'
Autor:
Paweł Stachura, Wei Liu, Haifeng C. Xu, Agnès Wlodarczyk, Olivia Stencel, Piyush Pandey, Melina Vogt, Sanil Bhatia, Daniel Picard, Marc Remke, Karl S. Lang, Dieter Häussinger, Bernhard Homey, Philipp A. Lang, Arndt Borkhardt, Aleksandra A. Pandyra
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-20 (2023)
Abstract Background New therapies are urgently needed in melanoma, particularly in late-stage patients not responsive to immunotherapies and kinase inhibitors. To uncover novel potentiators of T cell anti-tumor immunity, we carried out an ex vivo pha
Externí odkaz:
https://doaj.org/article/f770cd12a72b4c18be56dafec7315fc0
Autor:
Wei Liu, Arndt Borkhardt, Dieter Häussinger, Aleksandra A Pandyra, Philipp A Lang, Haifeng Xu, Daniel Picard, Marc Remke, Pawel Stachura, Agnes Wlodarczyk, Olivia Stencel, Piyush Pandey, Melina Vogt, Sanil Bhatia, Karl Lang, Bernhard Homey
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 2 (2023)
Externí odkaz:
https://doaj.org/article/e0db37258e4241de895a65ba647cf61d
Autor:
Chaohui Lin, Edmund Osei Kuffour, Nina V. Fuchs, Christoph G.W. Gertzen, Jesko Kaiser, Maximilian Hirschenberger, Xiao Tang, Haifeng C. Xu, Oliver Michel, Ronny Tao, Alexandra Haase, Ulrich Martin, Thomas Kurz, Ingo Drexler, Boris Görg, Philipp A. Lang, Tom Luedde, Konstantin M.J. Sparrer, Holger Gohlke, Renate König, Carsten Münk
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113277- (2023)
Summary: Sensing of human immunodeficiency virus type 1 (HIV-1) DNA is mediated by the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) signaling axis. Signal transduction and regulation of this cascade is achieved by post-translat
Externí odkaz:
https://doaj.org/article/a3e194c999a94c19ad46494fc14d84d4
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 166, Iss , Pp 115196- (2023)
Mammarenaviruses are enveloped RNA viruses that can be associated with rodent-transmitted diseases in humans. Their virions are composed of a nucleocapsid surrounded by a lipid bilayer with glycoprotein (GP) spikes interacting with receptors on targe
Externí odkaz:
https://doaj.org/article/6dcfdcfe689a4834b4f8f47877c10d2e
Autor:
Haifeng C. Xu, Jun Huang, Aleksandra A. Pandyra, Piyush Pandey, Ruifeng Wang, Zeli Zhang, Yuan Zhuang, Christoph G.W. Gertzen, Carsten Münk, Diran Herebian, Arndt Borkhardt, Mike Recher, Holger Gohlke, Irene Esposito, Martin Oberbarnscheidt, Dieter Häussinger, Karl S. Lang, Philipp A. Lang
Publikováno v:
Hepatology Communications, Vol 6, Iss 7, Pp 1620-1633 (2022)
Major histocompatibility complex I (MHC‐I) molecules present epitopes on the cellular surface of antigen‐presenting cells to prime cytotoxic clusters of differentiation 8 (CD8)+ T cells (CTLs), which then identify and eliminate other cells such a
Externí odkaz:
https://doaj.org/article/162c721aae254ca7b08f8550afa6f30a
Autor:
Davide G. Franchina, Henry Kurniawan, Melanie Grusdat, Carole Binsfeld, Luana Guerra, Lynn Bonetti, Leticia Soriano-Baguet, Anouk Ewen, Takumi Kobayashi, Sophie Farinelle, Anna Rita Minafra, Niels Vandamme, Anaïs Carpentier, Felix K. Borgmann, Christian Jäger, Ying Chen, Markus Kleinewietfeld, Vasilis Vasiliou, Michel Mittelbronn, Karsten Hiller, Philipp A. Lang, Dirk Brenner
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Follicular and marginal zone B (FoB and MZB, respectively) cells have divergent metabolic characteristics. Here the authors show that deficiency of glutamate cysteine ligase (Gclc), the enzyme for glutathione synthesis, differentially impacts FoB and
Externí odkaz:
https://doaj.org/article/82e7256382b44500933f4d48afe4151d
Autor:
Martha Paluschinski, Claus Kordes, Mihael Vucur, Veronika Buettner, Christoph Roderburg, Haifeng C. Xu, Prashant V. Shinte, Philipp A. Lang, Tom Luedde, Mirco Castoldi
Publikováno v:
Cells, Vol 12, Iss 15, p 1955 (2023)
Chronic inflammation is widely recognized as a significant factor that promotes and worsens the development of malignancies, including hepatocellular carcinoma. This study aimed to explore the potential role of microRNAs in inflammation-associated no
Externí odkaz:
https://doaj.org/article/593acba93f87463f820a5ac534d94324
Autor:
Nele Zoellner, Noémi Coesfeld, Frederik Henry De Vos, Jennifer Denter, Haifeng C. Xu, Elena Zimmer, Birgit Knebel, Hadi Al-Hasani, Sofie Mossner, Philipp A. Lang, Doreen M. Floss, Jürgen Scheller
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Type I interferons (IFNs) are potent inhibitors of viral replication. Here, we reformatted the natural murine and human type I interferon-α/β receptors IFNAR1 and IFNAR2 into fully synthetic biological switches. The transmembrane and intracellular
Externí odkaz:
https://doaj.org/article/a844187356564f8ba83cf36bff594e71
Autor:
Haifeng C. Xu, Ruifeng Wang, Prashant V. Shinde, Lara Walotka, Anfei Huang, Gereon Poschmann, Jun Huang, Wei Liu, Kai Stühler, Heiner Schaal, Andreas Bergthaler, Aleksandra A. Pandyra, Cornelia Hardt, Karl S. Lang, Philipp A. Lang
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Using different strains of the lymphocytic choriomeningitis virus (LCMV), Xu, Wang et al. show that a slow viral propagation limits type I interferon (IFN-I) production and viral persistence in mice. This study suggests a reduced viral propagation as
Externí odkaz:
https://doaj.org/article/e64f13b539b04accba130bd3d10b5844
Autor:
Judith Lang, Patrick Bohn, Hilal Bhat, Holger Jastrow, Bernd Walkenfort, Feyza Cansiz, Julian Fink, Michael Bauer, Dominik Olszewski, Ana Ramos-Nascimento, Vikas Duhan, Sarah-Kim Friedrich, Katrin Anne Becker, Adalbert Krawczyk, Michael J. Edwards, Andreas Burchert, Magdalena Huber, Justa Friebus-Kardash, Joachim R. Göthert, Cornelia Hardt, Hans Christian Probst, Fabian Schumacher, Karl Köhrer, Burkhard Kleuser, Eduard B. Babiychuk, Beate Sodeik, Jürgen Seibel, Urs F. Greber, Philipp A. Lang, Erich Gulbins, Karl S. Lang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Macrophages are critical in limiting replication of herpes simplex virus type 1 (HSV-1). Here the authors show how acid ceramidase and its enzymatic product sphingosine enable multivesicular bodies to function as an anti-viral mechanism.
Externí odkaz:
https://doaj.org/article/ce87beeac86246829e4b47c4ed971f39