Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Philipp, Ochtrop"'
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Akademický článek
Dephosphocholination by Legionella effector Lem3 functions through remodelling of the switch II region of Rab1b
Autor: Marietta S. Kaspers, Vivian Pogenberg, Christian Pett, Stefan Ernst, Felix Ecker, Philipp Ochtrop, Michael Groll, Christian Hedberg, Aymelt Itzen
Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Bacterial pathogens often make use of post-translational modifications to manipulate host cells. Legionella pneumophila, the causative agent of Legionnaires disease, secretes the enzyme AnkX that uses cytidine diphosphate-choline to post-tra
Externí odkaz: https://doaj.org/article/24651e6d5226410298bde574e8f3a727
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2
Compact hydrophilic electrophiles enable highly efficacious high DAR ADCs with excellent in vivo PK profile
Autor: Philipp Ochtrop, Jahaziel Jahzerah, Paul Machui, Isabelle Mai, Dominik Schumacher, Jonas Helma, Marc-André Kasper, Christian P. R. Hackenberger
Publikováno v: Chemical Science. 14:2259-2266
Compact phosphonamidate building blocks enable the simple construction of homogeneous DAR8 ADCs from native antibodies and hydrophobic payloads. The resulting ADCs exhibit excellent in vivo stability, clearance rates and antitumor activity.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c030d1f8e8859610dcb28140584d7e95
https://doi.org/10.1039/d2sc05678j
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6
Modular solid-phase synthesis of electrophilic cysteine-selective ethynyl-phosphonamidate peptides
Autor: Sarah Hansen, Jan Vincent V. Arafiles, Philipp Ochtrop, Christian P. R. Hackenberger
Publikováno v: Chemical communications (Cambridge, England). 58(60)
We report an efficient method to install electrophilic cysteine-selective ethynyl-phosphonamidates on peptides during Fmoc-based solid phase peptide synthesis (SPPS). By performing Staudinger-phosphonite reactions between different solid supported az
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fa3c78bd36f9a9c4e4d3a4b5f98f037
https://pubmed.ncbi.nlm.nih.gov/35792548
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7
Site‐Specific Antibody Fragment Conjugates for Reversible Staining in Fluorescence Microscopy
Autor: Ksenia Kolobynina, Christian P. R. Hackenberger, Heinrich Leonhardt, Jonathan Schwach, Katharina Brandstetter, Hartmann Harz, Philipp Ochtrop, M. Cristina Cardoso, Marcus Gerlach, Andreas Stengl, Jonas Helma
Publikováno v: Chembiochem
Antibody conjugates have taken a great leap forward as tools in basic and applied molecular life sciences that was enabled by the development of chemoselective reactions for the site‐specific modification of proteins. Antibody‐oligonucleotide con
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f27dd6f68b0c0052f4a0ccd141dc58
https://doi.org/10.1002/cbic.202000727
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8
DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling
Autor: Christian E. Stieger, Yerin Park, Mark A. R. de Geus, Dongju Kim, Christiane Huhn, J. Sophia Slenczka, Philipp Ochtrop, Judith M. Müchler, Roderich D. Süssmuth, Johannes Broichhagen, Mu‐Hyun Baik, Christian P. R. Hackenberger
Publikováno v: Angewandte Chemie (International ed. in English). 61(41)
We report the density functional theory (DFT) guided discovery of ethynyl‐triazolyl‐phosphinates (ETPs) as a new class of electrophilic warheads for cysteine selective bioconjugation. By using CuI‐catalysed azide alkyne cycloaddition (CuAAC) in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dbd48633e348bd025a0f82a98e3249b
https://pubmed.ncbi.nlm.nih.gov/35792701
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9
N ‐Hydroxysuccinimide‐Modified Ethynylphosphonamidates Enable the Synthesis of Configurationally Defined Protein Conjugates
Autor: Marcus Gerlach, Anselm F. L. Schneider, Dominik Schumacher, Marc-André Kasper, Jonas Helma, Christian P. R. Hackenberger, Stefanie Boldt, Heinrich Leonhardt, Mathias Christmann, Philipp Ochtrop, Christiane Groneberg
Publikováno v: Chembiochem
Herein, the application of N‐hydroxysuccinimide‐modified phosphonamidate building blocks for the incorporation of cysteine‐selective ethynylphosphonamidates into lysine residues of proteins, followed by thiol addition with small molecules and p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54dfa7c81315bdd6ecb44f243d35d28a
https://doi.org/10.1002/cbic.201900587
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