Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Philipp, Jakobs"'
Autor:
Dennis Merk, Fiona Frederike Cox, Philipp Jakobs, Simone Prömel, Joachim Altschmied, Judith Haendeler
Publikováno v:
Antioxidants, Vol 13, Iss 4, p 443 (2024)
The endothelium, the innermost cell layer of blood vessels, is not only a physical barrier between the bloodstream and the surrounding tissues but has also essential functions in vascular homeostasis. Therefore, it is not surprising that endothelial
Externí odkaz:
https://doaj.org/article/7d41ff5f850d4b349122e2854d517c0f
Autor:
Dennis Merk, Jan Greulich, Annika Vierkant, Fiona Cox, Olaf Eckermann, Florian von Ameln, Nadine Dyballa-Rukes, Joachim Altschmied, Niloofar Ale-Agha, Philipp Jakobs, Judith Haendeler
Publikováno v:
Antioxidants, Vol 12, Iss 6, p 1244 (2023)
The maintenance of Thioredoxin-1 (Trx-1) levels, and thus of cellular redox homeostasis, is vital for endothelial cells (ECs) to prevent senescence induction. One hallmark of EC functionality, their migratory capacity, which depends on intact mitocho
Externí odkaz:
https://doaj.org/article/b92924c50b2547cd84703aa0bc08e0b4
Autor:
Andrey Bogorodskiy, Ivan Okhrimenko, Ivan Maslov, Nina Maliar, Dmitrii Burkatovskii, Florian von Ameln, Alexey Schulga, Philipp Jakobs, Joachim Altschmied, Judith Haendeler, Alexandros Katranidis, Ivan Sorokin, Alexey Mishin, Valentin Gordeliy, Georg Büldt, Wolfgang Voos, Thomas Gensch, Valentin Borshchevskiy
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Mitochondrial protein biogenesis relies almost exclusively on the expression of nuclear-encoded polypeptides. The current model postulates that most of these proteins have to be delivered to their final mitochondrial destination after their synthesis
Externí odkaz:
https://doaj.org/article/16e2a2506edb4cd58990e060d3ca145f
Autor:
Vanessa Brinkmann, Margherita Romeo, Lucie Larigot, Anne Hemmers, Lisa Tschage, Jennifer Kleinjohann, Alfonso Schiavi, Swantje Steinwachs, Charlotte Esser, Ralph Menzel, Sara Giani Tagliabue, Laura Bonati, Fiona Cox, Niloofar Ale-Agha, Philipp Jakobs, Joachim Altschmied, Judith Haendeler, Xavier Coumoul, Natascia Ventura
Publikováno v:
Antioxidants, Vol 11, Iss 4, p 613 (2022)
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor whose activity can be modulated by polyphenols, such as curcumin. AhR and curcumin have evolutionarily conserved effects on aging. Here, we investigated whether and how th
Externí odkaz:
https://doaj.org/article/fae757d48604452eaa2ef9ce87487b2d
Publikováno v:
Redox Biology, Vol 34, Iss , Pp 101543- (2020)
Telomerase consists of the catalytic subunit Telomerase Reverse Transcriptase (TERT) and the Telomerase RNA Component. Its canonical function is the prevention of telomere erosion. Over the last years it became evident that TERT is also present in ti
Externí odkaz:
https://doaj.org/article/ca38d376c1114e0a8adede24934625e3
Autor:
Andrey Bogorodskiy, Ivan Okhrimenko, Dmitrii Burkatovskii, Philipp Jakobs, Ivan Maslov, Valentin Gordeliy, Norbert A. Dencher, Thomas Gensch, Wolfgang Voos, Joachim Altschmied, Judith Haendeler, Valentin Borshchevskiy
Publikováno v:
Cells, Vol 10, Iss 12, p 3528 (2021)
Mitochondria play a critical role in providing energy, maintaining cellular metabolism, and regulating cell survival and death. To carry out these crucial functions, mitochondria employ more than 1500 proteins, distributed between two membranes and t
Externí odkaz:
https://doaj.org/article/1466362e77944b6b96de255e8ac14b03
Autor:
Petra, Kleinbongard, Philipp, Kuthan, Chantal, Eickelmann, Philipp, Jakobs, Joachim, Altschmied, Judith, Haendeler, Arjang, Ruhparwar, Matthias, Thielmann, Gerd, Heusch
Publikováno v:
International Journal of Cardiology. 363:159-162
In patients undergoing interventional or surgical coronary revascularization, subclinical hypothyroidism is common and associated with worse outcome, including the need for postoperative inotropic support. In isolated rat hearts with global ischemia/
Autor:
Dennis Merk, Johannes Ptok, Philipp Jakobs, Florian von Ameln, Jan Greulich, Pia Kluge, Kathrin Semperowitsch, Olaf Eckermann, Heiner Schaal, Niloofar Ale-Agha, Joachim Altschmied, Judith Haendeler
Publikováno v:
Antioxidants, Vol 10, Iss 9, p 1427 (2021)
Sepsis is an exaggerated immune response upon infection with lipopolysaccharide (LPS) as the main causative agent. LPS-induced activation and apoptosis of endothelial cells (EC) can lead to organ dysfunction and finally organ failure. We previously d
Externí odkaz:
https://doaj.org/article/ad537b1b030145a1a01499ff88b43551
Autor:
Haendeler, Dennis Merk, Jan Greulich, Annika Vierkant, Fiona Cox, Olaf Eckermann, Florian von Ameln, Nadine Dyballa-Rukes, Joachim Altschmied, Niloofar Ale-Agha, Philipp Jakobs, Judith
Publikováno v:
Antioxidants; Volume 12; Issue 6; Pages: 1244
The maintenance of Thioredoxin-1 (Trx-1) levels, and thus of cellular redox homeostasis, is vital for endothelial cells (ECs) to prevent senescence induction. One hallmark of EC functionality, their migratory capacity, which depends on intact mitocho
Autor:
Marc Hannappel, Philipp Jakobs
Publikováno v:
Raumforschung und Raumordnung, Vol 77, Iss 3 (2019)
In this paper, we introduce a research approach which wants to be understood as a proposal for a new version of urban sociological and geographical activity-space research. The methodological approach is illustrated by an explorative study with stude
Externí odkaz:
https://doaj.org/article/f267b82a29fc492ca85c9d7fa821c9c0