Distribution of neurosensory progenitor pools during inner ear morphogenesis unveiled by cell lineage reconstruction

Autor: Sylvia Dyballa, Thierry Savy, Philipp Germann, Karol Mikula, Mariana Remesikova, Róbert Špir, Andrea Zecca, Nadine Peyriéras, Cristina Pujades

Publikováno v: eLife, Vol 6 (2017)

Reconstructing the lineage of cells is central to understanding how the wide diversity of cell types develops. Here, we provide the neurosensory lineage reconstruction of a complex sensory organ, the inner ear, by imaging zebrafish embryos in vivo ov

Externí odkaz: https://doaj.org/article/a4c5738134c942318fe1bbe6e8fb4f16

Antigen Availability and DOCK2-Driven Motility Govern CD4+ T Cell Interactions with Dendritic Cells In Vivo

Autor: James Sharpe, Jens V. Stein, Yoshinori Fukui, Jim Swoger, Jun Abe, Kathrin Gollmer, Markus Ackerknecht, Philipp Germann, Jorge Ripoll, Xenia Ficht

Publikováno v: The Journal of Immunology. 199:520-530

Parenchymal migration of naive CD4+ T cells in lymph nodes (LNs) is mediated by the Rac activator DOCK2 and PI3Kγ and is widely assumed to facilitate efficient screening of dendritic cells (DCs) presenting peptide-MHCs (pMHCs). Yet how CD4+ T cell m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e69d2edf76e736c1bb6394e103791f73
https://doi.org/10.4049/jimmunol.1601148

Salivary gland macrophages assist tissue-resident CD8+ T cell immune surveillance

Autor: Nicolas Page, Flavian Thelen, Xenia Ficht, Doron Merkler, Christoph Schlapbach, Nora Ruef, Francesca Barone, Oliver T. Fackler, Federica Moalli, V. V. G. K. Inavalli, Jens V. Stein, James Sharpe, U. V. Nägerl, Matteo Iannacone, Andrea Raimondi, Bettina Stolp, Lukas M. Altenburger, Matthias S. Dettmer, Philipp Germann, Kirsten A. Keyser, Seyed Morteza Seyed Jafari

Tissue macrophages and tissue resident memory CD8+ T cells (TRM) play important roles for pathogen sensing and rapid protection of barrier tissues. To date, it is incompletely understood how these two cell types cooperate for efficient organ surveill

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c2dde24631f757e36490c515352e952
https://doi.org/10.1101/723791

The Rho regulator Myosin IXb enables nonlymphoid tissue seeding of protective CD8 T cells

Autor: Mykhailo Vladymyrov, Ruth Lyck, Michael Sixt, Xenia Ficht, Alba Diz-Muñoz, Jasmin Balmer, Martin Bähler, Ingrid de Vries, Bettina Stolp, Matteo Iannacone, Jens V. Stein, Federica Moalli, Amleto Fiocchi, Doron Merkler, Michael Hubert Stoffel, Mario Kreutzfeldt, Akitaka Ariga, James Sharpe, Philipp Germann

Publikováno v: Moalli, Federica; Ficht, Xenia; Germann, Philipp; Vladymyrov, Mykhailo; Stolp, Bettina; de Vries, Ingrid; Lyck, Ruth; Balmer, Jasmin Maria; Fiocchi, Amleto; Kreutzfeldt, Mario; Merkler, Doron; Iannacone, Matteo; Ariga, Akitaka; Stoffel, Michael Hubert; Sharpe, James; Bähler, Martin; Sixt, Michael; Diz-Muñoz, Alba; Stein, Jens Volker (2018). The Rho regulator Myosin IXb enables nonlymphoid tissue seeding of protective CD8 T cells. Journal of experimental medicine, 215(7), pp. 1869-1890. Rockefeller University Press 10.1084/jem.20170896
The Journal of Experimental Medicine
Journal of Experimental Medicine, Vol. 215, No 7 (2018) pp. 1869-1890

Moalli et al. combine in vitro CD8+ T cell motility analysis with intravital imaging of mouse tissues to identify the actomyosin regulator Myo9b as a central player for nonlymphoid tissue infiltration during adaptive immune responses by facilitating

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd4de5cecfa49254e0fcb9a44b1977e9
https://boris.unibe.ch/117340/1/jem.20170896.full.pdf

How do digits emerge? - mathematical models of limb development

Autor: Philipp Germann, Dagmar Iber

Publikováno v: Birth Defects Research Part C: Embryo Today: Reviews. 102:1-12

The mechanism that controls digit formation has long intrigued developmental and theoretical biologists, and many different models and mechanisms have been proposed. Here we review models of limb development with a specific focus on digit and long bo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97817ef5f6ab88768514964f8927f01a
https://doi.org/10.1002/bdrc.21057