Zobrazeno 1 - 10
of 352
pro vyhledávání: '"Philipp, Beckhove"'
Autor:
Franziska Christine Sanna, Iva Benešová, Philip Pervan, Adriana Krenz, Alexander Wurzel, Robert Lohmayer, Jasmin Mühlbauer, Amélie Wöllner, Nina Köhl, Ayse Nur Menevse, Slava Stamova, Valentina Volpin, Philipp Beckhove, Maria Xydia
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IL-32 expression is important for pathogen clearance but detrimental in chronic inflammation, autoimmunity, and cancer. T cells are major IL-32 producers in these diseases and key mediators of pathogen and tumor elimination but also autoimmune destru
Externí odkaz:
https://doaj.org/article/716aa81b1a1448fd91912bdc2ffe9517
Autor:
Lorraine Weidner, Julia Lorenz, Stefanie Quach, Frank K. Braun, Tanja Rothhammer-Hampl, Laura-Marie Ammer, Arabel Vollmann-Zwerenz, Laura M. Bartos, Franziska J. Dekorsy, Adrien Holzgreve, Sabrina V. Kirchleitner, Niklas Thon, Tobias Greve, Viktoria Ruf, Jochen Herms, Stefanie Bader, Vladimir M. Milenkovic, Louisa von Baumgarten, Ayse N. Menevse, Abir Hussein, Julian Sax, Christian H. Wetzel, Rainer Rupprecht, Martin Proescholdt, Nils O. Schmidt, Philipp Beckhove, Peter Hau, Joerg-Christian Tonn, Peter Bartenstein, Matthias Brendel, Nathalie L. Albert, Markus J. Riemenschneider
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-21 (2023)
Abstract TSPO is a promising novel tracer target for positron-emission tomography (PET) imaging of brain tumors. However, due to the heterogeneity of cell populations that contribute to the TSPO-PET signal, imaging interpretation may be challenging.
Externí odkaz:
https://doaj.org/article/882098c23867491bad20bb37d6a6accc
Autor:
Ayse N. Menevse, Laura-Marie Ammer, Arabel Vollmann-Zwerenz, Marcell Kupczyk, Julia Lorenz, Lorraine Weidner, Abir Hussein, Julian Sax, Jasmin Mühlbauer, Nicole Heuschneider, Celine Rohrmus, Laura S. Mai, Birgit Jachnik, Slava Stamova, Valentina Volpin, Franziska C. Durst, Antonio Sorrentino, Maria Xydia, Vladimir M. Milenkovic, Stefanie Bader, Frank K. Braun, Christian Wetzel, Nathalie L. Albert, Joerg-Christian Tonn, Peter Bartenstein, Martin Proescholdt, Nils O. Schmidt, Ralf A. Linker, Markus J. Riemenschneider, Philipp Beckhove, Peter Hau
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-23 (2023)
Abstract Glioblastoma (GB) IDH-wildtype is the most malignant primary brain tumor. It is particularly resistant to current immunotherapies. Translocator protein 18 kDa (TSPO) is upregulated in GB and correlates with malignancy and poor prognosis, but
Externí odkaz:
https://doaj.org/article/5b085ac5cc8b49e9922c86d6fca1cd96
Autor:
Nathalie Babl, Joshua Hofbauer, Carina Matos, Florian Voll, Ayse Nur Menevse, Michael Rechenmacher, Ruth Mair, Philipp Beckhove, Wolfgang Herr, Peter J. Siska, Kathrin Renner, Marina Kreutz, Annette Schnell
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionThe discovery of immune checkpoints and the development of their specific inhibitors was acclaimed as a major breakthrough in cancer therapy. However, only a limited patient cohort shows sufficient response to therapy. Hence, there is a n
Externí odkaz:
https://doaj.org/article/665d9c3a8e194fc4aff448d9891a418f
Autor:
Jessica C. Hassel, Timo E. Schank, Heiko Smetak, Jasmin Mühlbauer, Martin Salzmann, Devayani Machiraju, Christian Menzer, Kristin Lang, Laila König, Matthias F. Haefner, Ingrid Hülsmeyer, Christian Kohler, Rainer Spang, Alexander Enk, Jürgen Debus, Philipp Beckhove
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
In patients with melanoma brain metastases (MBM), a combination of radiotherapy (RT) with immune checkpoint inhibitors (ICI) is routinely used. However, the best sequence of radio-immunotherapy (RIT) remains unclear. In an exploratory phase 2 trial,
Externí odkaz:
https://doaj.org/article/5c11e7dab9974230b5dc3d9f87c8177f
Autor:
Jessica Pinkert, Hans-Henning Boehm, Mark Trautwein, Wolf-Dietrich Doecke, Florian Wessel, Yingzi Ge, Eva Maria Gutierrez, Rafael Carretero, Christoph Freiberg, Uwe Gritzan, Merlin Luetke-Eversloh, Sven Golfier, Oliver Von Ahsen, Valentina Volpin, Antonio Sorrentino, Anchana Rathinasamy, Maria Xydia, Robert Lohmayer, Julian Sax, Ayse Nur-Menevse, Abir Hussein, Slava Stamova, Georg Beckmann, Julian Marius Glueck, Dorian Schoenfeld, Joerg Weiske, Dieter Zopf, Rienk Offringa, Bertolt Kreft, Philipp Beckhove, Joerg Willuda
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), a cell surface receptor, is expressed on normal epithelial tissue and highly expressed in cancers of high unmet medical need, such as non-small cell lung, pancreatic, and colorectal
Externí odkaz:
https://doaj.org/article/b51b522082204e19b3b78844000d71d5
Autor:
Frank K. Braun, Tanja Rothhammer-Hampl, Julia Lorenz, Sandra Pohl, Ayse-Nur Menevse, Arabel Vollmann-Zwerenz, Elisabeth Bumes, Maren Büttner, Saida Zoubaa, Martin Proescholdt, Nils O. Schmidt, Peter Hau, Philipp Beckhove, Beate Winner, Markus J. Riemenschneider
Publikováno v:
Cells, Vol 12, Iss 14, p 1856 (2023)
Conventional 2D cultures are commonly used in cancer research though they come with limitations such as the lack of microenvironment or reduced cell heterogeneity. In this study, we investigated in what respect a scaffold-based (Matrigel™) 3D cultu
Externí odkaz:
https://doaj.org/article/34a1a8f1e65a4f44afca380bf5cfda63
Autor:
Maria Xydia, Raheleh Rahbari, Eliana Ruggiero, Iain Macaulay, Maxime Tarabichi, Robert Lohmayer, Stefan Wilkening, Tillmann Michels, Daniel Brown, Sebastiaan Vanuytven, Svetlana Mastitskaya, Sean Laidlaw, Niels Grabe, Maria Pritsch, Raffaele Fronza, Klaus Hexel, Steffen Schmitt, Michael Müller-Steinhardt, Niels Halama, Christoph Domschke, Manfred Schmidt, Christof von Kalle, Florian Schütz, Thierry Voet, Philipp Beckhove
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The mechanisms that shape the regulatory T cell repertoire in patients with cancer are not completely understood. Here, the authors observe that, in breast cancer patients, tumor-resident regulatory T cells do not show clonal relationship with their
Externí odkaz:
https://doaj.org/article/564548dac492461fa165fbbe611c1237
Autor:
Christina Hartl, Tillmann Michels, Ronny Milde, Vanessa Klein, Philipp Beckhove, Hannes Loferer, Stefan Bissinger
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/423953da805c440f99710906966560cd
Autor:
Seyer Safi, Yoshikane Yamauchi, Slava Stamova, Anchana Rathinasamy, Jan op den Winkel, Simone Jünger, Mariana Bucur, Ludmilla Umansky, Arne Warth, Esther Herpel, Martin Eichhorn, Hauke Winter, Hans Hoffmann, Philipp Beckhove
Publikováno v:
OncoImmunology, Vol 8, Iss 12 (2019)
The efficacy of cancer immunotherapy may be improved by increasing the number of circulating tumor-reactive T cells. The bone marrow is a priming site and reservoir for such T cells. The characteristics of bone marrow-derived tumor-reactive T cells a
Externí odkaz:
https://doaj.org/article/9b284c118ada48228cc05419b6480e68