Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Philipe Gobeil"'
Autor:
Paulina Kaplonek, Deniz Cizmeci, Jessica Shih-Lu Lee, Sally A. Shin, Stephanie Fischinger, Philipe Gobeil, Stéphane Pillet, Nathalie Charland, Brian J. Ward, Galit Alter
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-11 (2023)
Abstract Despite the success of existing COVID-19 vaccine platforms, the persistent limitations in global deployment of vaccines and waning immunity exhibited by many of the currently deployed vaccine platforms have led to perpetual outbreaks of SARS
Externí odkaz:
https://doaj.org/article/d55dbfe42ce74d4cbb08ac3c06582bd4
Autor:
Nathalie Charland, Philipe Gobeil, Stéphane Pillet, Iohann Boulay, Annie Séguin, Alexander Makarkov, Gretchen Heizer, Kapil Bhutada, Asif Mahmood, Sonia Trépanier, Karen Hager, Julia Jiang-Wright, Judith Atkins, Pooja Saxena, Matthew P. Cheng, Donald C. Vinh, Philippe Boutet, François Roman, Robbert Van Der Most, Maria Angeles Ceregido, Marc Dionne, Guy Tellier, Jean-Sébastien Gauthier, Brandon Essink, Michael Libman, Jason Haffizulla, André Fréchette, Marc-André D’Aoust, Nathalie Landry, Brian J. Ward
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-13 (2022)
Abstract The rapid spread of SARS-CoV-2 continues to impact humanity on a global scale with rising total morbidity and mortality. Despite the development of several effective vaccines, new products are needed to supply ongoing demand and to fight var
Externí odkaz:
https://doaj.org/article/b6a4cc5cfcb64d00803666e2639e3ffb
Autor:
Philipe Gobeil, Stéphane Pillet, Iohann Boulay, Nathalie Charland, Aurélien Lorin, Matthew P. Cheng, Donald C. Vinh, Philippe Boutet, Robbert Van Der Most, François Roman, Maria Angeles Ceregido, Nathalie Landry, Marc-André D’Aoust, Brian J. Ward
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Here, the authors report results from a Phase 1 trial with an AS03-adjuvanted, plant-based virus-like particle displaying the spike protein of the ancestral SARS-CoV-2. Six months post-second dose, they observe good neutralizing antibody titers and T
Externí odkaz:
https://doaj.org/article/5f0bb8c08c0147bdb05f3296700f7ce0
Autor:
Stéphane Pillet, Prabhu S. Arunachalam, Guadalupe Andreani, Nadia Golden, Jane Fontenot, Pyone Pyone Aye, Katharina Röltgen, Gabrielle Lehmicke, Philipe Gobeil, Charlotte Dubé, Sonia Trépanier, Nathalie Charland, Marc-André D’Aoust, Kasi Russell-Lodrigue, Christopher Monjure, Robert V. Blair, Scott D. Boyd, Rudolf P. Bohm, Jay Rappaport, François Villinger, Nathalie Landry, Bali Pulendran, Brian J. Ward
Publikováno v:
Cellular and Molecular Immunology
Although antivirals are important tools to control severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, effective vaccines are essential to control the current coronavirus disease 2019 (COVID-19) pandemic. Plant-derived virus-like
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::196ab61cd1a7251d30167a864e952c12
https://doi.org/10.1038/s41423-021-00809-2
https://doi.org/10.1038/s41423-021-00809-2
Autor:
Karen Hager, Nathalie Landry, Pierre-Yves Charbonneau, Matthew P. Cheng, Marc-André D'Aoust, Alexander I. Makarkov, Judith Atkins, Asif Mahmood, Carolyn Finkle, Stéphane Pillet, Manon Couture, Iohann Boulay, Patricia Schimke, Annie Séguin, Sylvie St-Martin, Brian J. Ward, Jiwanjeet Dhaliwall, Philipe Gobeil, Sonia Trépanier
Publikováno v:
Nature Medicine
Several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are being deployed, but the global need greatly exceeds the supply, and different formulations might be required for specific populations. Here we report Day 42 interim saf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeef6537059b51258cd42e52027595d5
http://europepmc.org/articles/PMC8205852
http://europepmc.org/articles/PMC8205852
Autor:
Karen J, Hager, Gonzalo, Pérez Marc, Philipe, Gobeil, Ricardo S, Diaz, Gretchen, Heizer, Conrado, Llapur, Alexander I, Makarkov, Eduardo, Vasconcellos, Stéphane, Pillet, Fernando, Riera, Pooja, Saxena, Priscila, Geller Wolff, Kapil, Bhutada, Garry, Wallace, Hessam, Aazami, Christine E, Jones, Fernando P, Polack, Luciana, Ferrara, Judith, Atkins, Iohann, Boulay, Jiwanjeet, Dhaliwall, Nathalie, Charland, Manon M J, Couture, Julia, Jiang-Wright, Nathalie, Landry, Sophie, Lapointe, Aurélien, Lorin, Asif, Mahmood, Lawrence H, Moulton, Emmy, Pahmer, Julie, Parent, Annie, Séguin, Luan, Tran, Thomas, Breuer, Maria-Angeles, Ceregido, Marguerite, Koutsoukos, François, Roman, Junya, Namba, Marc-André, D'Aoust, Sonia, Trepanier, Yosuke, Kimura, Brian J, Ward, Steven, Zeig
Publikováno v:
The New England journal of medicine. 386(22)
Backgroud: coronavirus-like particles (CoVLP) that are produced in plants and display the prefusion spike glycoprotein of the original strain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are combined with an adjuvant (Adjuvant Syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a353a3d3b32eb6ee2aacee051da324f
https://pubmed.ncbi.nlm.nih.gov/35507476
https://pubmed.ncbi.nlm.nih.gov/35507476
Autor:
Brian J. Ward, Nathalie Charland, Nathalie Landry, Robbert van der Most, Donald C. Vinh, Maria de los Angeles Ceregido Perez, Aurélien Lorin, Matthew P. Cheng, Iohann Boulay, Stéphane Pillet, Marc-André D'Aoust, François Roman, Philipe Gobeil, Philippe Boutet
As the SARS-COV-2 pandemic evolves, what is expected of vaccines extends beyond efficacy to include consideration of both durability and variant cross-reactivity. This report expands on previously reported immunogenicity results from a Phase 1 trial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6d6b9b57bc834cf8b38f63643ac5f09
https://doi.org/10.1101/2021.08.04.21261507
https://doi.org/10.1101/2021.08.04.21261507
Autor:
Philipe Gobeil, Stéphane Pillet, Iohann Boulay, Annie Séguin, Alexander Makarkov, Gretchen Heizer, Kapil Bhutada, Asif Mahmood, Nathalie Charland, Sonia Trépanier, Karen Hager, Julia Jiang-Wright, Judith Atkins, Matthew P. Cheng, Donald C. Vinh, Philippe Boutet, François Roman, Robbert Van Der Most, Maria Angeles Ceregido, Marc Dionne, Guy Tellier, Jean-Sébastien Gauthier, Brandon Essink, Michael Libman, Jason Haffizulla, André Fréchette, Marc-André D’Aoust, Nathalie Landry, Brian J. Ward
The rapid spread of SARS-CoV-2 continues to impact humanity on a global scale with rising total morbidity and mortality. Despite the development of several effective vaccines, new products are needed to supply ongoing demand and the needs of specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7df6b201e4d79fbb42ddadc8142f064a
https://doi.org/10.1101/2021.05.14.21257248
https://doi.org/10.1101/2021.05.14.21257248
Autor:
Stéphane Pillet, Prabhu S. Arunachalam, Guadalupe Andreani, Nadia Golden, Jane Fontenot, Pyone Aye, Katharina Röltgen, Gabrielle Lehmick, Charlotte Dubé, Philipe Gobeil, Sonia Trépanier, Nathalie Charland, Marc-André D’Aoust, Kasi Russell-Lodrigue, Robert V. Blair, Scott Boyd, Rudolph B. Bohm, Jay Rappaport, François Villinger, Brian J. Ward, Bali Pulendran, Nathalie Landry
Although antivirals are important tools to control the SARS-CoV-2 infection, effective vaccines are essential to control the current pandemic. Plant-derived virus-like particle (VLP) vaccine candidates have previously demonstrated immunogenicity and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78523db4fe3a13c40d2ee0de25263a67
https://doi.org/10.1101/2021.05.15.444262
https://doi.org/10.1101/2021.05.15.444262
Autor:
Asif Mahmood, Annie Séguin, Matthew P. Cheng, Iohann Boulay, Karen Hager, Nathalie Landry, Sylvie St-Martin, Stéphane Pillet, Carolyn Finkle, Alexander I. Makarkov, Manon Couture, Pierre-Yves Charbonneau, Philipe Gobeil, Brian J. Ward, Jiwanjeet Dhaliwall, Judith Atkins, Sonia Trépanier, Patricia Schimke, Marc-André D'Aoust
Longer AbstractBackgroundThe stabilized prefusion form of the SARS-CoV-2 spike protein is produced by transient expression in Nicotiana benthamiana. The trimeric spike glycoproteins are displayed at the surface of self-assembling Virus-Like-Particles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f55faf7fd2b17904fddd4ad68830da74
https://doi.org/10.1101/2020.11.04.20226282
https://doi.org/10.1101/2020.11.04.20226282