Zobrazeno 1 - 10 of 72 pro vyhledávání: '"Philip W. Pemberton"'
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The impact of obesity and bariatric surgery on the immune microenvironment of the endometrium
Autor: Anie, Naqvi, Michelle L, MacKintosh, Abigail E, Derbyshire, Anna-Maria, Tsakiroglou, Thomas D J, Walker, Rhona J, McVey, James, Bolton, Martin, Fergie, Steven, Bagley, Garry, Ashton, Philip W, Pemberton, Akheel A, Syed, Basil J, Ammori, Richard, Byers, Emma J, Crosbie
Publikováno v: International journal of obesity (2005). 46(3)
The incidence of endometrial cancer is rising in parallel with the obesity epidemic. Obesity increases endometrial cancer risk and weight loss is protective, but the underlying mechanisms are incompletely understood. We hypothesise that the immune mi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cfe9657eac0a8683aa1ceb7d269950de
https://pubmed.ncbi.nlm.nih.gov/34857870
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7
Baseline serum HE4 but not tissue HE4 expression predicts response to the levonorgestrel-releasing intrauterine system in atypical hyperplasia and early stage endometrial cancer
Autor: Y Louise Wan, Roya Behrouzi, Chloe E Barr, Emma J Crosbie, Rhona J McVey, Zoe Maskell, Neil A J Ryan, Katie Stocking, James Bolton, Abigail E. Derbyshire, Philip W. Pemberton
Publikováno v: Behrouzi, R, Ryan, N, Barr, C, Derbyshire, A, Wan, L, Maskell, Z, Stocking, K, Pemberton, P, Bolton, J, McVey, R J & Crosbie, E 2020, ' Baseline serum HE4 but not tissue HE4 expression predicts response to the levonorgestrel-releasing intrauterine system in atypical hyperplasia and early stage endometrial cancer ', Cancers . https://doi.org/10.3390/cancers12020276
Cancers
Behrouzi, R, Ryan, N A J, Barr, C E, Derbyshire, A E, Wan, Y L, Maskell, Z, Stocking, K, Pemberton, P W, Bolton, J, McVey, R J & Crosbie, E J 2020, ' Baseline Serum HE4 But Not Tissue HE4 Expression Predicts Response to the Levonorgestrel-Releasing Intrauterine System in Atypical Hyperplasia and Early Stage Endometrial Cancer ', Cancers, vol. 12, no. 2 . https://doi.org/10.3390/cancers12020276
Cancers, Vol 12, Iss 2, p 276 (2020)
Volume 12
Issue 2
The levonorgestrel-releasing intrauterine system (LNG-IUS) is a conservative management option for atypical hyperplasia (AH) and low grade early stage endometrial cancer (EEC), but around 1 in 3 patients fail to respond to treatment. The aim of this
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7369e016706a52ad14911956f2ea52b2
https://doi.org/10.3390/cancers12020276
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8
The impact of obesity and bariatric surgery on circulating and tissue biomarkers of endometrial cancer risk
Autor: Babur Ahmed, Rhona J McVey, Emma J Crosbie, Martyna Kamieniorz, Catherine L. Higgins, Abigail E. Derbyshire, Basil J. Ammori, Akheel A. Syed, Andrew G Renehan, Philip W. Pemberton, Michelle L. MacKintosh, James Bolton, Henry C Kitchener, Mahshid Nickkho-Amiry, Bilal H. Kirmani
Publikováno v: Mackintosh, M, Derbyshire, A, McVey, R, Bolton, J, Nickkho-Amiry, M, Higgins, C L, Kamieniorz, M, Pemberton, P W, Kirmani, B H, Ahmed, B, Syed, A, Ammori, B, Renehan, A, Kitchener, H & Crosbie, E 2019, ' The impact of obesity and bariatric surgery on circulating and tissue biomarkers of endometrial cancer risk ', International Journal of Cancer, vol. 144, no. 3, pp. 641-650 . https://doi.org/10.1002/ijc.31913
International Journal of Cancer
Obesity is the strongest risk factor for endometrial cancer (EC). To inform targeted screening and prevention strategies, we assessed the impact of obesity and subsequent bariatric surgery‐induced weight loss on endometrial morphology and molecular
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f63088df8a68af9055966e6615d2e2f4
https://doi.org/10.1002/ijc.31913
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9
PROgesterone Therapy for Endometrial Cancer Prevention in Obese Women (PROTEC) Trial: A Feasibility Study
Autor: Abigail E. Derbyshire, Joseph Shaw, Henry C Kitchener, Philip W. Pemberton, Michelle L. MacKintosh, Richard J. Edmondson, Jennifer L. Allen, Emma J Crosbie, Bhavna Lakhiani, James Bolton, Matthew Gittins, Michelle Needham
Publikováno v: Derbyshire, A E, Allen, J L, Gittins, M, Lakhiani, B, Bolton, J, Shaw, J, Pemberton, P W, Needham, M, MacKintosh, M L, Edmondson, R J, Kitchener, H C & Crosbie, E J 2021, ' PROgesterone Therapy for Endometrial Cancer Prevention in Obese Women (PROTEC) Trial: A Feasibility Study ', Cancer Prevention Research, vol. 14, no. 2, pp. 263–274 . https://doi.org/10.1158/1940-6207.CAPR-20-0248
Obesity is the major etiologic driver for endometrial cancer. The levonorgestrel intrauterine system (LNG-IUS) reduces the risk of endometrial cancer and its precursor, atypical hyperplasia. We assessed feasibility and uptake of the LNG-IUS for prima
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e58ffda40a7c1aac434cc5a6e6adc021
https://doi.org/10.1097/ogx.0000000000000880
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10
Measuring the biological effect of presurgical metformin treatment in endometrial cancer
Autor: Philip W. Pemberton, Kyle Gilmour, Emma J Crosbie, Henry C Kitchener, Andrew G Renehan, Sarah Kitson, Chris Roberts, Rhona J McVey, Vanitha N Sivalingam, S Ali
Publikováno v: British Journal of Cancer
Sivalingam, V N, Kitson, S, McVey, R, Roberts, C, Pemberton, P, Gilmour, K, Ali, S, Renehan, A G, Kitchener, H C & Crosbie, E J 2016, ' Measuring the biological effect of presurgical metformin treatment in endometrial cancer ', British Journal of Cancer, vol. 114, no. 3, pp. 281-289 . https://doi.org/10.1038/bjc.2015.453
BACKGROUND: Preclinical studies in endometrial cancer (EC) show that metformin reduces cellular proliferation by PI3K-AKT-mTOR inhibition. We tested the hypothesis that short-term presurgical metformin reduces cellular proliferation in atypical endom
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db4c882dbe65382a4cb633885859ad02
https://doi.org/10.1038/bjc.2015.453
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