Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Philip W. Melchert"'
Publikováno v:
Medical Cannabis and Cannabinoids, Vol 7, Iss 1, Pp 1-9 (2024)
Introduction: Cannabidiol (CBD) is a widely utilized nonpsychoactive cannabinoid available as a prescriptive drug treatment and over-the-counter supplement. In humans, CBD is metabolized and forms the major active metabolite 7-hydroxy-cannabidiol (7-
Externí odkaz:
https://doaj.org/article/acfb1ea05b024034a49daf84af17a8c7
Autor:
John S. Markowitz, Ludmila De Faria, Qingchen Zhang, Philip W. Melchert, Reginald F. Frye, Brandon O. Klee, Yuli Qian
Publikováno v:
Medical Cannabis and Cannabinoids, Vol 5, Iss 1, Pp 199-206 (2022)
Introduction: Cannabidiol (CBD) is a widely utilized nonpsychoactive cannabinoid available as an over-the-counter supplement, a component of medical cannabis, and a prescriptive treatment of childhood epilepsies. In vitro studies suggest CBD may inhi
Externí odkaz:
https://doaj.org/article/b6cc5d042a37487ebd1d16fc30802139
Autor:
John S, Markowitz, Philip W, Melchert
Publikováno v:
Child and Adolescent Psychiatric Clinics of North America. 31:393-416
The psychostimulants-amphetamine and methylphenidate-have been in clinical use for well more than 60 years. In general, both stimulants are rapidly absorbed with relatively poor bioavailability and short half-lives. The pharmacokinetics of both stimu
Publikováno v:
Chemico-biological interactions. 368
Beclomethasone dipropionate (BDP) is an inhaled glucocorticoid used for maintenance treatment of asthma in adults and children. BDP is a prodrug activated in lung when hydrolyzed to its major active metabolite beclomethasone-17-monopropionate (17-BMP
Autor:
Philip W. Melchert, Yuli Qian, Qingchen Zhang, Brandon O. Klee, Chengguo Xing, John S. Markowitz
Publikováno v:
Chem Biol Interact
Kava refers to the extracts from the rhizome of the plant Piper methysticum which is of particular significance to various indigenous cultures in the South Pacific region. Kavalactones are the active constituents of kava products and are associated w
Publikováno v:
Chemico-Biological Interactions. 365:110097
Remdesivir (RDV, Veklury®) is an FDA-approved prodrug for the treatment of hospitalized patients with COVID-19. Recent in vitro studies have indicated that human carboxylesterase 1 (CES1) is the major metabolic enzyme catalyzing RDV activation. COVI