Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Philip W. Jordan"'
Publikováno v:
BMC Molecular and Cell Biology, Vol 21, Iss 1, Pp 1-10 (2020)
Abstract Background The SMC5/6 complex, cohesin and condensin are the three mammalian members of the structural maintenance of chromosomes (SMC) family, large ring-like protein complexes that are essential for genome maintenance. The SMC5/6 complex i
Externí odkaz:
https://doaj.org/article/2ed88bebed5a4bf2b6e7f64efa35f0b5
Publikováno v:
Stem Cell Research, Vol 49, Iss , Pp 102078- (2020)
The auxin-inducible degron (AID) system is becoming a widely used method for rapid and reversible degradation of target proteins. This system has been successfully used to study gene and protein functions in eukaryotic cells and common model organism
Externí odkaz:
https://doaj.org/article/842dc1005aef46c58b28b2e03adbcd2e
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 6, Pp 1713-1724 (2016)
Cohesin is an essential structural component of chromosomes that ensures accurate chromosome segregation during mitosis and meiosis. Previous studies have shown that there are cohesin complexes specific to meiosis, required to mediate homologous chro
Externí odkaz:
https://doaj.org/article/78ec0f15a6ab4644a24ff8538235b782
Autor:
Marina Martinez-Garcia, Pedro Robles Naharro, Marnie W Skinner, Kerstin A Baran, Laura I Lascarez-Lagunas, Saravanapriah Nadarajan, Nara Shin, Carlos G Silva-García, Takamune T Saito, Sara Beese-Sims, Brianna N Diaz-Pacheco, Elizaveta Berson, Ana B Castañer, Sarai Pacheco, Enrique Martinez-Perez, Philip W Jordan, Monica P Colaiácovo
Publikováno v:
PLoS Genetics, Vol 19, Iss 2, p e1010666 (2023)
Chromosome movements and licensing of synapsis must be tightly regulated during early meiosis to ensure accurate chromosome segregation and avoid aneuploidy, although how these steps are coordinated is not fully understood. Here we show that GRAS-1,
Externí odkaz:
https://doaj.org/article/256d8d7b5f334b59810c1d4d8aae4a05
Autor:
Alisa Atkins, Michelle J Xu, Maggie Li, Nathaniel P Rogers, Marina V Pryzhkova, Philip W Jordan
Publikováno v:
eLife, Vol 9 (2020)
Mutations of SMC5/6 components cause developmental defects, including primary microcephaly. To model neurodevelopmental defects, we engineered a mouse wherein Smc5 is conditionally knocked out (cKO) in the developing neocortex. Smc5 cKO mice exhibite
Externí odkaz:
https://doaj.org/article/80616597eed84aafa9e4ee3b267f4985
Publikováno v:
Tissue Engineering and Regenerative Medicine. 19:1185-1206
Our learning about human reproductive development is greatly hampered due to the absence of an adequate model. Animal studies cannot truthfully recapitulate human developmental processes, and studies of human fetal tissues are limited by their availa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13aeff165592f9b1b1692a4a27c01c7e
https://doi.org/10.1007/s13770-022-00492-y
https://doi.org/10.1007/s13770-022-00492-y
Autor:
Thao P. Phan, Christina A. Boatwright, Chelsea G. Drown, Marnie W. Skinner, Margaret A. Strong, Philip W. Jordan, Andrew J. Holland
Publikováno v:
Genes & Development. 36:718-736
Centrosomes are microtubule-organizing centers comprised of a pair of centrioles and the surrounding pericentriolar material. Abnormalities in centriole number are associated with cell division errors and can contribute to diseases such as cancer. Ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b4a856b1cb437ebb72deea39e8dc8e2
https://doi.org/10.1101/gad.349604.122
https://doi.org/10.1101/gad.349604.122
Autor:
Raul Ayala Davila, Cassy Spiller, Danyon Harkins, Tracey Harvey, Philip W Jordan, Richard M Gronostajski, Michael Piper, Josephine Bowles
Publikováno v:
Biology of Reproduction. 106:1191-1205
Members of the nuclear factor I (NFI) family are key regulators of stem cell biology during development, with well-documented roles for NFIA, NFIB, and NFIX in a variety of developing tissues, including brain, muscle, and lung. Given the central role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e7c2e1f8de9e79a335939ee210740c
https://doi.org/10.1093/biolre/ioac049
https://doi.org/10.1093/biolre/ioac049
Autor:
Marina Martinez-Garcia, Pedro Robles Naharro, Marnie W. Skinner, Kerstin A. Baran, Saravanapriah Nadarajan, Nara Shin, Carlos G. Silva-García, Takamune T. Saito, Sara Beese-Sims, Ana Castaner, Sarai Pacheco, Enrique Martinez-Perez, Philip W. Jordan, Monica P. Colaiácovo
Chromosome movements and licensing of synapsis must be tightly regulated during early meiosis to ensure accurate chromosome segregation and avoid aneuploidy, although how these steps are coordinated is not fully understood. Here we show that GRAS-1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b889bdda1e1cd72b9071936c64db34f
https://doi.org/10.1101/2022.09.06.506874
https://doi.org/10.1101/2022.09.06.506874
Publikováno v:
Molecular Biology of the Cell. 33
Homologous recombination (HR) is an essential meiotic process that contributes to the genetic variation of offspring and ensures accurate chromosome segregation. Recombination is facilitated by the formation and repair of programmed DNA double-strand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5004e21dae6a48028b83d7b280b96186
https://doi.org/10.1091/mbc.e21-03-0115
https://doi.org/10.1091/mbc.e21-03-0115