Zobrazeno 1 - 10 of 85 pro vyhledávání: '"Philip W. Iversen"'
1
Akademický článek
Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade
Autor: Rikke B. Holmgaard, David A. Schaer, Yanxia Li, Stephen P. Castaneda, Mary Y. Murphy, Xiaohong Xu, Ivan Inigo, Julie Dobkin, Jason R. Manro, Philip W. Iversen, David Surguladze, Gerald E. Hall, Ruslan D. Novosiadly, Karim A. Benhadji, Gregory D. Plowman, Michael Kalos, Kyla E. Driscoll
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-15 (2018)
Abstract Background TGFβ signaling plays a pleotropic role in tumor biology, promoting tumor proliferation, invasion and metastasis, and escape from immune surveillance. Inhibiting TGFβ’s immune suppressive effects has become of particular intere
Externí odkaz: https://doaj.org/article/add74ac3d1f847239e42c3dd99f9f142
Zobrazit plný text záznamu
2
Akademický článek
The CDK4/6 Inhibitor Abemaciclib Induces a T Cell Inflamed Tumor Microenvironment and Enhances the Efficacy of PD-L1 Checkpoint Blockade
Autor: David A. Schaer, Richard P. Beckmann, Jack A. Dempsey, Lysiane Huber, Amelie Forest, Nelusha Amaladas, Yanxia Li, Ying Cindy Wang, Erik R. Rasmussen, Darin Chin, Andrew Capen, Carmine Carpenito, Kirk A. Staschke, Linda A. Chung, Lacey M. Litchfield, Farhana F. Merzoug, Xueqian Gong, Philip W. Iversen, Sean Buchanan, Alfonso de Dios, Ruslan D. Novosiadly, Michael Kalos
Publikováno v: Cell Reports, Vol 22, Iss 11, Pp 2978-2994 (2018)
Summary: Abemaciclib, an inhibitor of cyclin dependent kinases 4 and 6 (CDK4/6), has recently been approved for the treatment of hormone receptor-positive breast cancer. In this study, we use murine syngeneic tumor models and in vitro assays to inves
Externí odkaz: https://doaj.org/article/1595454cd7fc4830988cdc917336d3e6
Zobrazit plný text záznamu
3
Akademický článek
Visualizing Experimental Designs for Balanced ANOVA Models using Lisp-Stat
Autor: Philip W. Iversen, Mervyn Marasinghe
Publikováno v: Journal of Statistical Software, Vol 13, Iss 1, Pp 1-18 (2004)
The structure, or Hasse, diagram described by Taylor and Hilton (1981, American Statistician) provides a visual display of the relationships between factors for balanced complete experimental designs. Using the Hasse diagram, rules exist for determin
Externí odkaz: https://doaj.org/article/090b8625ffe14431b7907b61a1346a09
Zobrazit plný text záznamu
4
Akademický článek
Visualizing Experimental Designs for Balanced ANOVA Models using Lisp-Stat
Autor: Mervyn G. Marasinghe, Philip W. Iversen
Publikováno v: Journal of Statistical Software, Vol 13, Iss 3 (2004)
Externí odkaz: https://doaj.org/article/3e1c97d7e5a74bf59dd1cc63c511e8d1
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje