Zobrazeno 1 - 10
of 227
pro vyhledávání: '"Philip W Shaul"'
Autor:
Haaris S Khan, Vidhya R Nair, Cody R Ruhl, Samuel Alvarez-Arguedas, Jorge L Galvan Rendiz, Luis H Franco, Linzhang Huang, Philip W Shaul, Jiwoong Kim, Yang Xie, Ron B Mitchell, Michael U Shiloh
Publikováno v:
eLife, Vol 9 (2020)
Mycobacterium tuberculosis (Mtb) can enter the body through multiple routes, including via specialized transcytotic cells called microfold cells (M cell). However, the mechanistic basis for M cell entry remains undefined. Here, we show that M cell tr
Externí odkaz:
https://doaj.org/article/d7ed44f0af13427d8e7d84d1abe3eaa6
Autor:
Chieko Mineo, Lane Lanier, Eunjeong Jung, Samarpita Sengupta, Victoria Ulrich, Anastasia Sacharidou, Cristina Tarango, Olutoye Osunbunmi, Yu-Min Shen, Jane E Salmon, Rolf A Brekken, Xianming Huang, Philip E Thorpe, Philip W Shaul
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158757 (2016)
In the antiphospholipid syndrome (APS), patients produce antiphospholipid antibodies (aPL) that promote thrombosis and adverse pregnancy outcomes. Current therapy with anticoagulation is only partially effective and associated with multiple complicat
Externí odkaz:
https://doaj.org/article/80a2662e356745ec8bfd2beb3e0b1582
Autor:
Wan Ru Lee, Anastasia Sacharidou, Erica Behling-Kelly, Sarah C Oltmann, Weifei Zhu, Mohamed Ahmed, Robert D Gerard, David Y Hui, Jun-ichi Abe, Philip W Shaul, Chieko Mineo
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124494 (2015)
Scavenger receptor class B, type I (SR-BI) and its adaptor protein PDZK1 mediate responses to HDL cholesterol in endothelium. Whether the receptor-adaptor protein tandem serves functions in other vascular cell types is unknown. The current work deter
Externí odkaz:
https://doaj.org/article/e2b973d5016a45f9a94ab230058b7b74
Autor:
Anastasia Sacharidou, Ken Chambliss, Jun Peng, Jose Barrera, Keiji Tanigaki, Katherine Luby-Phelps, İpek Özdemir, Sohaib Khan, Shashank R. Sirsi, Sung Hoon Kim, Benita S. Katzenellenbogen, John A. Katzenellenbogen, Mohammed Kanchwala, Adwait A. Sathe, Andrew Lemoff, Chao Xing, Kenneth Hoyt, Chieko Mineo, Philip W. Shaul
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The estrogen receptor (ER) designated ERα has actions in many cell and tissue types that impact glucose homeostasis. It is unknown if these include mechanisms in endothelial cells, which have the potential to influence relative obesity, and
Externí odkaz:
https://doaj.org/article/a6ad2b7de7ba40389fc7ade98aaa8270
Autor:
Liming Yu, Lin Xu, Haiyan Chu, Jun Peng, Anastasia Sacharidou, Hsi-hsien Hsieh, Ada Weinstock, Sohaib Khan, Liqian Ma, José Gabriel Barcia Durán, Jeffrey McDonald, Erik R. Nelson, Sunghee Park, Donald P. McDonnell, Kathryn J. Moore, Lily Jun-shen Huang, Edward A. Fisher, Chieko Mineo, Linzhang Huang, Philip W. Shaul
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Hypercholesterolemia and vascular inflammation are key interconnected contributors to the pathogenesis of atherosclerosis. How hypercholesterolemia initiates vascular inflammation is poorly understood. Here we show in male mice that hypercho
Externí odkaz:
https://doaj.org/article/acdb55d979ff40c6a879b2daab171d43
Autor:
Juan Pang, Fitore Raka, Alya Abbas Heirali, Weijuan Shao, Dinghui Liu, Jianqiu Gu, Jia Nuo Feng, Chieko Mineo, Philip W. Shaul, Xiaoxian Qian, Bryan Coburn, Khosrow Adeli, Wenhua Ling, Tianru Jin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Two common features of dietary polyphenols have hampered our mechanistic understanding of their beneficial effects for decades: targeting multiple organs and extremely low bioavailability. We show here that resveratrol intervention (REV-I) i
Externí odkaz:
https://doaj.org/article/7768586838704f1f9466b8b884b7e232
Autor:
Jun Peng, Liming Yu, Linzhang Huang, Vivian A. Paschoal, Haiyan Chu, Camila O. de Souza, Joseph V. Varre, Da Young Oh, Jennifer J. Kohler, Xue Xiao, Lin Xu, William L. Holland, Philip W. Shaul, Chieko Mineo
Publikováno v:
Molecular Metabolism, Vol 78, Iss , Pp 101812- (2023)
Objective: Sialic acid is a terminal monosaccharide of glycans in glycoproteins and glycolipids, and its derivation from glucose is regulated by the rate-limiting enzyme UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE). Although the glycans on key endogeno
Externí odkaz:
https://doaj.org/article/30b337ca0b494154b0feb5d864b44adc
Autor:
Chia-Hua Wu, Ling Guo, Dan Hao, Qian Wang, Xiang Ye, Misa Ito, Bin Huang, Chieko Mineo, Philip W. Shaul, Xiang-An Li
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
Introduction25-60% of septic patients experience relative adrenal insufficiency (RAI) and glucocorticoid (GC) is frequently used in septic patients. However, the efficacy of GC therapy and whether GC therapy should be based on the status of RAI are h
Externí odkaz:
https://doaj.org/article/0ae938b34934449fa69392cb8dd35394
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 5, Pp 986-997 (2015)
ABCA1 plays a key role in the initial lipidation of apoA-I, which generates circulating HDL cholesterol. Whereas it is known that the transcriptional upregulation of ABCA1 promotes HDL formation and reverse cholesterol transport (RCT), it is not know
Externí odkaz:
https://doaj.org/article/bac49f617f7a4fcfbee7d308682843b8
27-Hydroxycholesterol Binds GPER and Induces Progression of Estrogen Receptor-Negative Breast Cancer
Autor:
Paola Avena, Ivan Casaburi, Lucia Zavaglia, Marta C. Nocito, Davide La Padula, Vittoria Rago, Jing Dong, Peter Thomas, Chieko Mineo, Rosa Sirianni, Philip W. Shaul
Publikováno v:
Cancers; Volume 14; Issue 6; Pages: 1521
Cholesterol affects the proliferation of breast cancer (BC) and in particular of estrogen receptor-negative (ER−) BC. Cholesterol is converted to 27-hydroxycholesterol (27HC), which promotes the growth of ER+ BC. Potentially, 27HC can be involved i