Zobrazeno 1 - 10
of 912
pro vyhledávání: '"Philip W Kantoff"'
Autor:
Sai Harisha Rajanala, Romina Ghale, Subhiksha Nandakumar, Kalyani Chadalavada, Gwo-Shu Mary Lee, Konrad H Stopsack, Yu Chen, Gouri J Nanjangud, Goutam Chakraborty, Philip W Kantoff
Publikováno v:
PLoS ONE, Vol 19, Iss 4, p e0301989 (2024)
Somatic Y chromosome loss in hematopoietic cells is associated with higher mortality in men. However, the status of the Y chromosome in cancer tissue is not fully known due to technical limitations, such as difficulties in labelling and sequencing DN
Externí odkaz:
https://doaj.org/article/9f025f8d20d746c0a246657541807f95
Autor:
Konrad H Stopsack, Svitlana Tyekucheva, Molin Wang, Travis A Gerke, J Bailey Vaselkiv, Kathryn L Penney, Philip W Kantoff, Stephen P Finn, Michelangelo Fiorentino, Massimo Loda, Tamara L Lotan, Giovanni Parmigiani, Lorelei A Mucci
Publikováno v:
eLife, Vol 10 (2021)
Tissue microarrays (TMAs) have been used in thousands of cancer biomarker studies. To what extent batch effects, measurement error in biomarker levels between slides, affects TMA-based studies has not been assessed systematically. We evaluated 20 pro
Externí odkaz:
https://doaj.org/article/5d3559e372204133ba3415106d7b03ea
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184166 (2017)
MicroRNAs (miRNAs) play important roles in cancer formation and progression by suppressing the production of key functional proteins at the post-transcriptional level in a sequence-specific manner. While differential expression of miRNAs is widely ob
Externí odkaz:
https://doaj.org/article/8b28177419a64fe5bb34e0f60ad50e19
Autor:
Mark M Pomerantz, Yashaswi Shrestha, Richard J Flavin, Meredith M Regan, Kathryn L Penney, Lorelei A Mucci, Meir J Stampfer, David J Hunter, Stephen J Chanock, Eric J Schafer, Jennifer A Chan, Josep Tabernero, José Baselga, Andrea L Richardson, Massimo Loda, William K Oh, Philip W Kantoff, William C Hahn, Matthew L Freedman
Publikováno v:
PLoS Genetics, Vol 6, Iss 11, p e1001204 (2010)
Genome-wide association studies (GWAS) have established a variant, rs10993994, on chromosome 10q11 as being associated with prostate cancer risk. Since the variant is located outside of a protein-coding region, the target genes driving tumorigenesis
Externí odkaz:
https://doaj.org/article/dc6fbfe2b95b4198812b5ad9f1ad0a44
Autor:
Yuki Yoshikawa, Konrad H. Stopsack, Xin Victoria Wang, Yu‐Hui Chen, Ying Z. Mazzu, Foster Burton, Goutam Chakraborty, Sai Harisha Rajanala, Rahim Hirani, Subhiksha Nandakumar, Gwo‐Shu Mary Lee, David Frank, Elai Davicioni, Glenn Liu, Michael A. Carducci, Haruhito Azuma, Philip W. Kantoff, Christopher J. Sweeney
Publikováno v:
Molecular Oncology, Vol 16, Iss 22, Pp 3994-4010 (2022)
Loss of the histone demethylase KDM5D (lysine‐specific demethylase 5D) leads to in vitro resistance of prostate cancer cells to androgen deprivation therapy (ADT) with and without docetaxel. We aimed to define downstream drivers of the KDM5D effect
Externí odkaz:
https://doaj.org/article/f3e5c6df0fe14e4b96ddc7e70c0635e6
Autor:
Ying Z. Mazzu, YuRou Liao, Subhiksha Nandakumar, Martin Sjöström, Lina E. Jehane, Romina Ghale, Barani Govindarajan, Travis A. Gerke, Gwo‐Shu Mary Lee, Jian‐Hua Luo, Sreenivasa R. Chinni, Lorelei A. Mucci, Felix Y. Feng, Philip W. Kantoff
Publikováno v:
Molecular Oncology, Vol 16, Iss 13, Pp 2451-2469 (2022)
Prostate cancer is a highly heterogeneous disease, understanding the crosstalk between complex genomic and epigenomic alterations will aid in developing targeted therapeutics. We demonstrate that, even though snail family transcriptional repressor 2
Externí odkaz:
https://doaj.org/article/1e7d977b030b44b383eed28d4cf9959d
Autor:
Lorelei A. Mucci, Jacob Vinson, Theresa Gold, Travis Gerke, Julie Filipenko, Rebecca M. Green, Simon G. Anderson, Simone Badal, Anders Bjartell, Kim N. Chi, Ian D. Davis, Deborah Enting, André P. Fay, John Lazarus, Joaquin Mateo, Ray McDermott, Folakemi T. Odedina, David Olmos, Aurelius Omlin, Ademola A. Popoola, Camille Ragin, Robin Roberts, Kjell M. Russnes, Charles Waihenya, Konrad H. Stopsack, Terry Hyslop, Paul Villanti, Philip W. Kantoff, Daniel J. George
Publikováno v:
JCO Global Oncology, Vol , Iss 8 (2022)
PURPOSETo describe a newly established international registry recruiting diverse patients with advanced prostate cancer across academic and community practices to address unmet needs in this population.PATIENTS AND METHODSInitiated in 2017, IRONMAN (
Externí odkaz:
https://doaj.org/article/c2ac1375880a4f8296dca71b57375939
Autor:
David P. Labbé, Giorgia Zadra, Meng Yang, Jaime M. Reyes, Charles Y. Lin, Stefano Cacciatore, Ericka M. Ebot, Amanda L. Creech, Francesca Giunchi, Michelangelo Fiorentino, Habiba Elfandy, Sudeepa Syamala, Edward D. Karoly, Mohammed Alshalalfa, Nicholas Erho, Ashley Ross, Edward M. Schaeffer, Ewan A. Gibb, Mandeep Takhar, Robert B. Den, Jonathan Lehrer, R. Jeffrey Karnes, Stephen J. Freedland, Elai Davicioni, Daniel E. Spratt, Leigh Ellis, Jacob D. Jaffe, Anthony V. DʼAmico, Philip W. Kantoff, James E. Bradner, Lorelei A. Mucci, Jorge E. Chavarro, Massimo Loda, Myles Brown
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Prostate cancer progression may be enhanced by a high-fat diet. Here the authors show that a diet high in saturated fats enhance the MYC-driven transcriptional program, a feature that independently predicts prostate cancer progression and death.
Externí odkaz:
https://doaj.org/article/ad31beb7d54c47838760eb7ff3f13cf9
Autor:
Leander Van Neste, Kirk J. Wojno, Ricardo Henao, Shrikant Mane, Howard Korman, Jason Hafron, Kenneth Kernen, Rima Tinawi-Aljundi, Mathew Putzi, Amin I. Kassis, Philip W. Kantoff
Publikováno v:
Cells, Vol 10, Iss 10, p 2567 (2021)
The primary objective of this study is to detect biomarkers and develop models that enable the identification of clinically significant prostate cancer and to understand the biologic implications of the genes involved. Peripheral blood samples (1018
Externí odkaz:
https://doaj.org/article/5a1827c9a5934f58ae6864cae3e91697
Autor:
Matthew L. Freedman, Philip W. Kantoff, William K. Oh, Mari Nakabayashi, Gillian Petrozziello, Carolyn Evan, Tong Sun, Gwo-Shu Mary Lee, Meredith M. Regan, Wanling Xie, Lillian Werner, Mark M. Pomerantz
Supplementary Table S4 from Association of Prostate Cancer Risk Loci with Disease Aggressiveness and Prostate Cancer–Specific Mortality
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdb6c6708913047d007b25b7658a48a6
https://doi.org/10.1158/1940-6207.22524114
https://doi.org/10.1158/1940-6207.22524114
