Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Philip W Jordan"'
Autor:
Marina Martinez-Garcia, Pedro Robles Naharro, Marnie W Skinner, Kerstin A Baran, Laura I Lascarez-Lagunas, Saravanapriah Nadarajan, Nara Shin, Carlos G Silva-García, Takamune T Saito, Sara Beese-Sims, Brianna N Diaz-Pacheco, Elizaveta Berson, Ana B Castañer, Sarai Pacheco, Enrique Martinez-Perez, Philip W Jordan, Monica P Colaiácovo
Publikováno v:
PLoS Genetics, Vol 19, Iss 2, p e1010666 (2023)
Chromosome movements and licensing of synapsis must be tightly regulated during early meiosis to ensure accurate chromosome segregation and avoid aneuploidy, although how these steps are coordinated is not fully understood. Here we show that GRAS-1,
Externí odkaz:
https://doaj.org/article/256d8d7b5f334b59810c1d4d8aae4a05
Autor:
Alisa Atkins, Michelle J Xu, Maggie Li, Nathaniel P Rogers, Marina V Pryzhkova, Philip W Jordan
Publikováno v:
eLife, Vol 9 (2020)
Mutations of SMC5/6 components cause developmental defects, including primary microcephaly. To model neurodevelopmental defects, we engineered a mouse wherein Smc5 is conditionally knocked out (cKO) in the developing neocortex. Smc5 cKO mice exhibite
Externí odkaz:
https://doaj.org/article/80616597eed84aafa9e4ee3b267f4985
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0159800 (2016)
After using a self-inactivating lentivirus for non-targeted insertional mutagenesis in mice, we identified a transgenic family with a recessive mutation that resulted in reduced fertility in homozygous transgenic mice. The lentiviral integration site
Externí odkaz:
https://doaj.org/article/0ef7f3cff9624175b7215410433ae908
Autor:
Jessica Hopkins, Grace Hwang, Justin Jacob, Nicklas Sapp, Rick Bedigian, Kazuhiro Oka, Paul Overbeek, Steve Murray, Philip W Jordan
Publikováno v:
PLoS Genetics, Vol 10, Iss 7, p e1004413 (2014)
Cohesins are important for chromosome structure and chromosome segregation during mitosis and meiosis. Cohesins are composed of two structural maintenance of chromosomes (SMC1-SMC3) proteins that form a V-shaped heterodimer structure, which is bridge
Externí odkaz:
https://doaj.org/article/9dd713b03e2d4bbc818503a00de3fe8f
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83982 (2013)
Cells coordinate spindle formation with DNA repair and morphological modifications to chromosomes prior to their segregation to prevent cell division with damaged chromosomes. Here we uncover a novel and unexpected role for Aurora kinase in preventin
Externí odkaz:
https://doaj.org/article/260580a5988a450499d0cd59b1563b1b
Autor:
Alice Copsey, Shangming Tang, Philip W Jordan, Hannah G Blitzblau, Sonya Newcombe, Andrew Chi-Ho Chan, Louise Newnham, Zhaobo Li, Stephen Gray, Alex D Herbert, Prakash Arumugam, Andreas Hochwagen, Neil Hunter, Eva Hoffmann
Publikováno v:
PLoS Genetics, Vol 9, Iss 12, p e1004071 (2013)
During meiosis, Structural Maintenance of Chromosome (SMC) complexes underpin two fundamental features of meiosis: homologous recombination and chromosome segregation. While meiotic functions of the cohesin and condensin complexes have been delineate
Externí odkaz:
https://doaj.org/article/6f1f83f61b76484d99accc095955f5a7
Autor:
Philip W Jordan, Nigel J Saunders
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5198 (2009)
Neisseria meningitidis requires iron, and in the absence of iron alters its gene expression to increase iron acquisition and to make the best use of the iron it has. During different stages of colonization and infection available iron sources differ,
Externí odkaz:
https://doaj.org/article/01eea2927eaf4cc4b777f29682cbfad7
Publikováno v:
PLoS Genetics, Vol 3, Iss 12, p e222 (2007)
High-throughput studies of the 6,200 genes of Saccharomyces cerevisiae have provided valuable data resources. However, these resources require a return to experimental analysis to test predictions. An in-silico screen, mining existing interaction, ex
Externí odkaz:
https://doaj.org/article/a1de4583658e47f8819fda481cd9a000
Autor:
Michelle J. Xu, Philip W. Jordan
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 952 (2024)
It is widely accepted that DNA replication fork stalling is a common occurrence during cell proliferation, but there are robust mechanisms to alleviate this and ensure DNA replication is completed prior to chromosome segregation. The SMC5/6 complex h
Externí odkaz:
https://doaj.org/article/0182bd6351784e4088b23d228762c482
Autor:
Matthew P. O’Brien, Marina V. Pryzhkova, Evelyn M. R. Lake, Francesca Mandino, Xilin Shen, Ruchika Karnik, Alisa Atkins, Michelle J. Xu, Weizhen Ji, Monica Konstantino, Martina Brueckner, Laura R. Ment, Mustafa K. Khokha, Philip W. Jordan
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 430 (2023)
Up to 50% of patients with severe congenital heart disease (CHD) develop life-altering neurodevelopmental disability (NDD). It has been presumed that NDD arises in CHD cases because of hypoxia before, during, or after cardiac surgery. Recent studies
Externí odkaz:
https://doaj.org/article/5e913b781ba2448aafbf6fb6c995f84b