Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Philip W, Howard"'
Autor:
Marco Gymnopoulos, Oscar Betancourt, Vincent Blot, Ryo Fujita, Diana Galvan, Vincent Lieuw, Sophie Nguyen, Jeanette Snedden, Christine Stewart, Jose Villicana, Jon Wojciak, Eley Wong, Raul Pardo, Neki Patel, Francois D’Hooge, Balakumar Vijayakrishnan, Conor Barry, John A. Hartley, Philip W. Howard, Roland Newman, Julia Coronella
Publikováno v:
Molecular Oncology, Vol 14, Iss 1, Pp 54-68 (2020)
cMet is a well‐characterized oncogene that is the target of many drugs including small molecule and biologic pathway inhibitors, and, more recently, antibody–drug conjugates (ADCs). However, the clinical benefit from cMet‐targeted therapy has b
Externí odkaz:
https://doaj.org/article/deb621ff4dba44b3a242c7c4570c902e
Autor:
Arnaud C. Tiberghien, Balakumar Vijayakrishnan, Arman Esfandiari, Mahammad Ahmed, Raul Pardo, John Bingham, Lauren Adams, Kathleen Santos, Gyoung-Dong Kang, Kathryn M. Pugh, Shameen Afif-Rider, Kapil Vashisht, Kemal Haque, Ravinder Tammali, Edward Rosfjord, Adriana Savoca, John A. Hartley, Philip W. Howard
Publikováno v:
Molecular Cancer Therapeutics. 22:254-263
Antibody-drug conjugates (ADCs) delivering pyrrolobenzodiazepine (PBD) DNA crosslinkers are currently being evaluated in clinical trials with encouraging results in Hodgkin and non-Hodgkin lymphomas. The first example of an ADC delivering a PBD DNA c
Autor:
Philip W. Howard, John A. Hartley, Mary McFarlane, Luke A. Masterson, Kathryn Ball, Conor S. Barry, Lauren Adams, Rhiannon Beard, K. Phin Chooi, Gyoung-Dong Kang, Ian Hutchinson, Jitka Riedl, Kathleen Santos, Balakumar Vijayakrishnan, Shameen Afif-Rider, Neki Patel, Kathryn Pugh, Stephen J. Gregson
Supplementary Data from Efficacy, Tolerability, and Pharmacokinetic Studies of Antibody–Drug Conjugates Containing a Low-Potency Pyrrolobenzodiazepine Dimer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0808e71ffb8fdea67b4acfbd119e387a
https://doi.org/10.1158/1535-7163.22523461.v1
https://doi.org/10.1158/1535-7163.22523461.v1
Autor:
John A. Hartley, Patrick H. van Berkel, Philip W. Howard, David G. Williams, Paul W.H.I. Parren, Teresa Marafioti, Francois D'Hooge, Conor Barry, Luke A. Masterson, Arnaud Tiberghien, Jean-Noel Levy, Carin E.G. Havenith, Charles E. Britten, Narinder Janghra, Ayse U. Akarca, Peter C. Tyrer, Francesca Zammarchi, Michael J. Flynn
MTS assays on cell lines after treatment with ADCT-301, Non-binding ADC and naked antibody, HuMax-TAC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cab9c15f4c9a2e0ecf693cb26650fa5
https://doi.org/10.1158/1535-7163.22506658.v1
https://doi.org/10.1158/1535-7163.22506658.v1
Autor:
Adeela Kamal, Ronald Herbst, Robert E. Hollingsworth, David A. Tice, Philip W. Howard, Keven Huang, Mary Jane Hinrichs, Elaine M. Hurt, Haihong Zhong, Marlon Rebelatto, Sanjoo Jalla, Lilian van Vlerken-Ysla, Shannon Breen, Leslie Wetzel, Cui Chen, Linda Xu, Patrick Strout, Martin Korade, Allison M. Marrero, Shenlan Mao, Francois D'Hooge, Ryan Fleming, Jelena Jovanovic, David Bannister, Leeanne Lewis, Rose Marwood, Dorin Toader, Nazzareno Dimasi, Christopher Lloyd, Jay Harper
Supplementary Figure S1. Comparable internalization rates for 5T4_0108 and the 5T4-Tub ADC;Supplementary Figure S2. Affinity optimization improves in vitro cytotoxicity of a 5T4-ADC;Supplementary Figure S3. Induction of apoptosis by 5T4-PBD and 5T4-T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de526dbdf0be492e85149344521acac5
https://doi.org/10.1158/1535-7163.22508511
https://doi.org/10.1158/1535-7163.22508511
Autor:
Jay Harper, Mark Cobbold, David A. Tice, Philip W. Howard, Ronald Herbst, Herren Wu, Changshou Gao, Luke A. Masterson, Kimberly Cook, Kathryn Pugh, Susan Wilson, Nazzareno Dimasi, Jens-Oliver Koopmann, Sonja Hess, Ryan Fleming, Sandrina Phipps, Allison M. Barrett, Hong Chen, Andrew Garcia, Gina D’Angelo, Wen Yu, Raghothama Chaerkady, Shenlan Mao
The addition of the ATR inhibitor, AZD6738, did not show synergistic cytotoxicity with SG3199 or ADCs in parental MDA-MB-361 cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63d95af0ffa8c167232f6d1a26846154
https://doi.org/10.1158/1535-7163.22521297.v1
https://doi.org/10.1158/1535-7163.22521297.v1
Autor:
Jay Harper, Mark Cobbold, David A. Tice, Philip W. Howard, Ronald Herbst, Herren Wu, Changshou Gao, Luke A. Masterson, Kimberly Cook, Kathryn Pugh, Susan Wilson, Nazzareno Dimasi, Jens-Oliver Koopmann, Sonja Hess, Ryan Fleming, Sandrina Phipps, Allison M. Barrett, Hong Chen, Andrew Garcia, Gina D’Angelo, Wen Yu, Raghothama Chaerkady, Shenlan Mao
Differentially expressed proteins identified in the 361-PBDr cell line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c24ef074a6decab4f3756699682b81e
https://doi.org/10.1158/1535-7163.22521276.v1
https://doi.org/10.1158/1535-7163.22521276.v1
Autor:
John A. Hartley, Patrick H. van Berkel, Philip W. Howard, David G. Williams, Paul W.H.I. Parren, Teresa Marafioti, Francois D'Hooge, Conor Barry, Luke A. Masterson, Arnaud Tiberghien, Jean-Noel Levy, Carin E.G. Havenith, Charles E. Britten, Narinder Janghra, Ayse U. Akarca, Peter C. Tyrer, Francesca Zammarchi, Michael J. Flynn
Despite the many advances in the treatment of hematologic malignancies over the past decade, outcomes in refractory lymphomas remain poor. One potential strategy in this patient population is the specific targeting of IL2R-α (CD25), which is overexp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94d87c9eaa1b67f3d27abdb314cb187b
https://doi.org/10.1158/1535-7163.c.6538456.v1
https://doi.org/10.1158/1535-7163.c.6538456.v1
Autor:
Patrick H. van Berkel, Ronald Herbst, David A. Tice, Steve Coats, John A. Hartley, Philip W. Howard, Neil H. Bander, Sae Kim, He Liu, Eva Corey, Simon Chivers, Mary Jane Masson Hinrichs, Martin Korade, Patrick Strout, Kevin Schifferli, Ravinder Tammali, Karma Dacosta, Wanda King, Charles E. Britten, Sandamali Dissanayake, Halla W. Reinert, Lauren Adams, Simon Corbett, Francois Bertelli, Nazzareno Dimasi, Kapil Vashisht, Ryan Fleming, Francois D'Hooge, Peter Tyrer, Noel R. Monks, Carin E.G. Havenith, David G. Williams, Francesca Zammarchi, Song Cho
Supplementary Figure S1. Retention of MEDI3726 activity in human, cynomolgus monkey plasma or PBS for up to 7 days. Supplementary Figure S2. Kaplan-Meier analysis of the Time-to-Endpoint Survival in the (A) LNCaP, (B) CWR22Rv1, and (C) PC-3 Xenograft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fba3333e7f01b57533060b9dc76a71f
https://doi.org/10.1158/1535-7163.22505436.v1
https://doi.org/10.1158/1535-7163.22505436.v1
Autor:
John A. Hartley, Patrick H. van Berkel, Philip W. Howard, David G. Williams, Paul W.H.I. Parren, Teresa Marafioti, Francois D'Hooge, Conor Barry, Luke A. Masterson, Arnaud Tiberghien, Jean-Noel Levy, Carin E.G. Havenith, Charles E. Britten, Narinder Janghra, Ayse U. Akarca, Peter C. Tyrer, Francesca Zammarchi, Michael J. Flynn
In vivo efficacy in Karpas disseminated models. Kaplan Meier survival plots of disseminated Karpas 299 models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37d89da2396830a9cd4a1808fac4ffc2
https://doi.org/10.1158/1535-7163.22506649
https://doi.org/10.1158/1535-7163.22506649