Výsledky vyhledávání - "Philip T. Nowicki"

Oral Tetrahydrobiopterin Improves the Beneficial Effect of Adenoviral-mediated eNOS Gene Transfer After Induction of Hindlimb Ischemia

Autor: Jinglian Yan, Louis M. Messina, Yagai Yang, Guodong Tie, Philip T. Nowicki, Ari Hoffman

Publikováno v: Molecular Therapy. 18:1482-1489

We tested the hypothesis that oral supplementation with the endothelial nitric oxide synthase (eNOS) cofactor tetrahydrobiopterin (BH(4)) improved the therapeutic efficacy of eNOS gene transfer in the ischemic rat hindlimb. BH(4) or vehicle were begu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d53674c811cd3da6dafb7af5374d4370
https://doi.org/10.1038/mt.2010.109

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Endothelial nitric oxide synthase affects both early and late collateral arterial adaptation and blood flow recovery after induction of hind limb ischemia in mice

Autor: Ari Hoffman, Hossein Bagshahi, Philip T. Nowicki, Louis M. Messina, Yagai Yang, Jinglian Yan, Guodong Tie, Brian Park

Publikováno v: Journal of Vascular Surgery. 51(1):165-173

ObjectiveThe goals of this study were to determine if endothelial nitric oxide synthase (eNOS) affects both early and late collateral arterial adaptation and blood flow recovery after severe limb ischemia in a mouse model and to determine if eNOS-der

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af3c4e2710f56e3b67ab59391b2a7b44

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Oxidized Low-Density Lipoprotein Induces Apoptosis in Endothelial Progenitor Cells by Inactivating the Phosphoinositide 3-Kinase/Akt Pathway

Autor: Brian Park, Louis M. Messina, Guodong Tie, Jinglian Yan, Philip T. Nowicki, Julia A. Messina, Robert L. Raffai, Yagai Yang

Publikováno v: Journal of Vascular Research. 47:519-530

We tested the hypothesis that oxidized low-density lipoprotein (oxLDL)-induced inactivation of Akt within endothelial progenitor cells (EPCs) is mediated at the level of Phosphoinositide 3-kinase (PI3K), specifically by nitrosylation of the p85 subun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d94259afb6c522587be5a9041463db0
https://doi.org/10.1159/000313879

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Regenerative medicine in the treatment of peripheral arterial disease

Autor: Philip T. Nowicki, Louis M. Messina, Erica B. Sneider

Publikováno v: Journal of Cellular Biochemistry. 108:753-761

The last decade has witnessed a dramatic increase in the mechanistic understanding of angiogenesis and arteriogenesis, the two processes by which the body responds to obstruction of large conduit arteries. This knowledge has been translated into nove

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66c65531aa417d0dd1d9646a85c17d89
https://doi.org/10.1002/jcb.22315

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Endothelial Nitric Oxide Synthase in Human Intestine Resected for Necrotizing Enterocolitis

Autor: Kristina M. Reber, Philip T. Nowicki, Gail E. Besner, Craig A. Nankervis, Donna A. Caniano, Sue Hammond, Peter J. Giannone

Publikováno v: The Journal of Pediatrics. 150:40-45

Objective To determine the expression and function of endothelial nitric oxide synthase (eNOS) in submucosal arterioles harvested from human intestine resected for necrotizing enterocolitis (NEC) or congenital bowel disease. Study design eNOS express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eda6ef05519936f0a58fd7c091696bd
https://doi.org/10.1016/j.jpeds.2006.09.029

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IL-1β alters hemodynamics in newborn intestine: role of endothelin

Autor: Philip T. Nowicki

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 291:G404-G413

Studies were carried out to determine the effects of IL-1β on newborn intestinal hemodynamics. IL-1β increased the release of ET-1 by primary endothelial cells in a dose-dependent manner; as well, it reduced expression of the endothelin (ET) type B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac54888d0361d498f71b7ec004d35112
https://doi.org/10.1152/ajpgi.00042.2006

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The Effect of Phenotype on Mechanical Stretch-Induced Vascular Smooth Muscle Cell Apoptosis

Autor: Philip T. Nowicki, Kimberly M. Shontz, Baogen Y. Su, Nicholas A. Flavahan

Publikováno v: Journal of Vascular Research. 43:229-237

The present study evaluated mechanical stretch-induced apoptosis in swine vascular smooth muscle cells (VSMC) of different phenotypes. We demonstrated that differentiated VSMC express a greater level of Bcl-2-associated death factor (BAD) and have a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc5e0642149d28400920a315de8b5787
https://doi.org/10.1159/000091102

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Ischemia and necrotizing enterocolitis: Where, when, and how

Autor: Philip T. Nowicki

Publikováno v: Seminars in Pediatric Surgery. 14:152-158

While it is accepted that ischemia contributes to the pathogenesis of necrotizing enterocolitis (NEC), three important questions regarding this role subsist. First, where within the intestinal circulation does the vascular pathophysiology occur? It i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d2456bcc3c2804e0f1135d6bef66e1
https://doi.org/10.1053/j.sempedsurg.2005.05.003

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