Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Philip T. Liu"'
Autor:
Carter Gottlieb, Mason Henrich, Philip T. Liu, Vahe Yacoubian, Jeffery Wang, Rene Chun, John S. Adams
Publikováno v:
Nutrients, Vol 15, Iss 6, p 1380 (2023)
Vitamin D is known to modulate human immune responses, and vitamin D deficiency is associated with increased susceptibility to infection. However, what constitutes sufficient levels or whether vitamin D is useful as an adjuvant therapeutic is debated
Externí odkaz:
https://doaj.org/article/19c912bfb8394918b7a554d09a54eb3d
Autor:
Elliot W. Kim, Avelino De Leon, Zhichun Jiang, Roxana A. Radu, Adrian R. Martineau, Edward D. Chan, Xiyuan Bai, Wen-Lin Su, Dennis J. Montoya, Robert L. Modlin, Philip T. Liu
Publikováno v:
mSphere, Vol 4, Iss 3 (2019)
ABSTRACT Epidemiological evidence correlates low serum vitamin A (retinol) levels with increased susceptibility to active tuberculosis (TB); however, retinol is biologically inactive and must be converted into its bioactive form, all-trans retinoic a
Externí odkaz:
https://doaj.org/article/d742d0149e544e31881c00788a5150dc
Autor:
Elliot W. Kim, Santhosh M. Nadipuram, Ashley L. Tetlow, William D. Barshop, Philip T. Liu, James A. Wohlschlegel, Peter J. Bradley
Publikováno v:
mSphere, Vol 1, Iss 2 (2016)
ABSTRACT Toxoplasma gondii uses unique secretory organelles called rhoptries to inject an array of effector proteins into the host cytoplasm that hijack host cell functions. We have discovered a novel rhoptry pseudokinase effector, ROP54, which is in
Externí odkaz:
https://doaj.org/article/f969dd0a7b064a0e898dc43410fb7afe
Autor:
Jeff Drew, Raymond C.B. Wong, Brett Morimoto, Shahrooz Rabizadeh, Peter A. Sieling, Lennie Sender, Pete Bone, Daniel C. Sanford, Patrick Soon-Shiong, Andrew Bacon, Victor Peykov, Patricia Spilman, Adrian Rice, Jeffrey T. Safrit, Mohit Verma, Lise Zakin, Joseph P. Balint, Kyle Dinkins, Hermes Garban, Ashish Bezawada, Kayvan Niazi, Annie Shin, Philip T. Liu, Helty Adisetiyo, Elizabeth Gabitzsch
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
We have developed a dual-antigen COVID-19 vaccine incorporating genes for a modified SARS-CoV-2 spike protein (S-Fusion) and the viral nucleocapsid (N) protein with an Enhanced T-cell Stimulation Domain (N-ETSD) to increase the potential for MHC clas
Autor:
Manali D Mehta, Philip T Liu
Publikováno v:
Frontiers in Genetics, Vol 5 (2014)
As the role of microRNA in all aspects of biology continues to be unraveled, the interplay between microRNAs and human disease is becoming clearer. It should come of no surprise that microRNAs play a major part in the outcome of infectious diseases,
Externí odkaz:
https://doaj.org/article/bd10f678bc454b2fbdb201df6aafb493
Autor:
Helty Adisetiyo, Justin Taft, Lennie Sender, Marta Martín-Fernández, Sofija Buta, Kayvan Niazi, Elizabeth Gabitzsch, Peter A. Sieling, Philip T. Liu, Roosheel S. Patel, Adrian Rice, Lise Zakin, Patricia Spilman, Annie Shin, Shahrooz Rabizadeh, Hermes Garban, Jeffrey T. Safrit, Brett Morimoto, Dusan Bogunovic, Patrick Soon-Shiong
To address the need for a safe, efficacious vaccine against SARS-CoV-2 infection with the critical properties of enabling both blocking viral entry into cells and clearing virus from cells already infected, we have developed a bivalent, human adenovi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca8b60d0f264831585871b1076cbb46d
https://doi.org/10.1101/2020.11.04.20225417
https://doi.org/10.1101/2020.11.04.20225417
Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responses.
Autor:
Philip T Liu, Mirjam Schenk, Valencia P Walker, Paul W Dempsey, Melissa Kanchanapoomi, Matthew Wheelwright, Aria Vazirnia, Xiaoran Zhang, Andreas Steinmeyer, Ulrich Zügel, Bruce W Hollis, Genhong Cheng, Robert L Modlin
Publikováno v:
PLoS ONE, Vol 4, Iss 6, p e5810 (2009)
Antimicrobial effector mechanisms are central to the function of the innate immune response in host defense against microbial pathogens. In humans, activation of Toll-like receptor 2/1 (TLR2/1) on monocytes induces a vitamin D dependent antimicrobial
Externí odkaz:
https://doaj.org/article/d2709e7c21bd4bed8b82ec2be53446fd
Autor:
Kislay Parvatiyar, Robert L. Modlin, Euzenir Nunes Sarno, Barry R. Bloom, Genhong Cheng, Rosane M. B. Teles, Philip T. Liu, Maria Teresa Ochoa, Annalisa Legaspi, Aaron Choi, Angeline Tilly Dang, Michel Gilliet
Publikováno v:
JCI insight, vol 4, iss 8
Dang, Angeline Tilly; Teles, Rosane Mb; Liu, Phillip T; Choi, Aaron; Legaspi, Annalisa; Sarno, Euzenir N; et al.(2019). Autophagy links antimicrobial activity with antigen presentation in Langerhans cells.. JCI insight, 4(8). doi: 10.1172/jci.insight.126955. UCLA: Retrieved from: http://www.escholarship.org/uc/item/6584h5s6
Dang, Angeline Tilly; Teles, Rosane Mb; Liu, Phillip T; Choi, Aaron; Legaspi, Annalisa; Sarno, Euzenir N; et al.(2019). Autophagy links antimicrobial activity with antigen presentation in Langerhans cells.. JCI insight, 4(8). doi: 10.1172/jci.insight.126955. UCLA: Retrieved from: http://www.escholarship.org/uc/item/6584h5s6
DC, through the uptake, processing, and presentation of antigen, are responsible for activation of T cell responses to defend the host against infection, yet it is not known if they can directly kill invading bacteria. Here, we studied in human lepro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44ce097a4e0c936b51446479a4aae72c
https://escholarship.org/uc/item/6584h5s6
https://escholarship.org/uc/item/6584h5s6
Autor:
Kathryn Zavala, Carter A. Gottlieb, Martin Hewison, Robert L. Modlin, John S. Adams, Rosane M. B. Teles, Philip T. Liu
Publikováno v:
PLoS Neglected Tropical Diseases
Zavala, Kathryn; Gottlieb, Carter A; Teles, Rosane M; Adams, John S; Hewison, Martin; Modlin, Robert L; et al.(2018). Intrinsic activation of the vitamin D antimicrobial pathway by M. leprae infection is inhibited by type I IFN.. PLoS neglected tropical diseases, 12(10), e0006815. doi: 10.1371/journal.pntd.0006815. UCLA: Retrieved from: http://www.escholarship.org/uc/item/4tr261r6
PLoS neglected tropical diseases, vol 12, iss 10
PLoS Neglected Tropical Diseases, Vol 12, Iss 10, p e0006815 (2018)
Zavala, Kathryn; Gottlieb, Carter A; Teles, Rosane M; Adams, John S; Hewison, Martin; Modlin, Robert L; et al.(2018). Intrinsic activation of the vitamin D antimicrobial pathway by M. leprae infection is inhibited by type I IFN.. PLoS neglected tropical diseases, 12(10), e0006815. doi: 10.1371/journal.pntd.0006815. UCLA: Retrieved from: http://www.escholarship.org/uc/item/4tr261r6
PLoS neglected tropical diseases, vol 12, iss 10
PLoS Neglected Tropical Diseases, Vol 12, Iss 10, p e0006815 (2018)
Following infection, virulent mycobacteria persist and grow within the macrophage, suggesting that the intrinsic activation of an innate antimicrobial response is subverted by the intracellular pathogen. For Mycobacterium leprae, the intracellular ba
Publikováno v:
PLoS neglected tropical diseases, vol 12, iss 7
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 12, Iss 7, p e0006608 (2018)
Kim, Elliot W; Teles, Rosane MB; Haile, Salem; Liu, Philip T; & Modlin, Robert L. (2018). Vitamin D status contributes to the antimicrobial activity of macrophages against Mycobacterium leprae.. PLoS neglected tropical diseases, 12(7), e0006608. doi: 10.1371/journal.pntd.0006608. UCLA: Retrieved from: http://www.escholarship.org/uc/item/6wg8k5pv
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 12, Iss 7, p e0006608 (2018)
Kim, Elliot W; Teles, Rosane MB; Haile, Salem; Liu, Philip T; & Modlin, Robert L. (2018). Vitamin D status contributes to the antimicrobial activity of macrophages against Mycobacterium leprae.. PLoS neglected tropical diseases, 12(7), e0006608. doi: 10.1371/journal.pntd.0006608. UCLA: Retrieved from: http://www.escholarship.org/uc/item/6wg8k5pv
Background The immune system depends on effector pathways to eliminate invading pathogens from the host in vivo. Macrophages (MΦ) of the innate immune system are armed with vitamin D-dependent antimicrobial responses to kill intracellular microbes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d4023b30d30128e6754c351e1e50a0d
https://escholarship.org/uc/item/6wg8k5pv
https://escholarship.org/uc/item/6wg8k5pv