Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Philip Saxton"'
Autor:
Boris M. Seletsky, Karen TenDyke, Sean Eckley, Bruce A. Littlefield, Huiming Zhang, Hong Du, Carlson Eric, Wanjun Zheng, Yimin Jiang, Sridhar Narayan, Murray J. Towle, Yongbo Hu, Edgar Schuck, Krista Condon, Vipul Kumar, Hongsheng Cheng, Bryan M. Lewis, Philip Saxton, Melvin J. Yu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:1639-1643
Novel second generation analogs of eribulin mesylate, a tubulin agent recently approved for the treatment of breast cancer, are reported. Our recent efforts have focused on expanding the target indications for this class of compounds to other tumor t
Autor:
Y. Nancy Wong, Zhiyi Zhang, Meng Ye, Edgar Schuck, Christopher Rowbottom, Vipul Kumar, Philip Saxton, Robert D. Pelletier, Nadia Farah, Belinda M. King, Krista Condon
Publikováno v:
Cancer chemotherapy and pharmacology. 69(1)
E6201 is a natural product–inspired novel inhibitor of mitogen-activated protein kinase/extracellular signal–regulated kinase kinase-1 (MEK1) and other kinases and is currently under development as an anticancer (parenteral administration) and an
Autor:
Edgar Schuck, Bruce A. Littlefield, Sean Eckley, Wanjun Zheng, Hongsheng Cheng, Huiming Zhang, Melvin J. Yu, Hong Du, Yimin Jiang, Carlson Eric, Yongbo Hu, Karen TenDyke, Murray J. Towle, Bryan M. Lewis, Philip Saxton, Boris M. Seletsky, Vipul Kumar, Krista Condon, Sridhar Narayan
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(6)
Eribulin mesylate is a newly approved treatment for locally advanced and metastatic breast cancer. We targeted oral bioavailability and efficacy against multidrug resistant (MDR) tumors for further work. The design, synthesis and evaluation of novel
Autor:
Junke, Liu, Murray J, Towle, Hongsheng, Cheng, Philip, Saxton, Cathy, Reardon, Jiayi, Wu, Erin A, Murphy, Galina, Kuznetsov, Charles W, Johannes, Martin R, Tremblay, Hongjuan, Zhao, Marc, Pesant, Francis G, Fang, Mary W, Vermeulen, Brian M, Gallagher, Bruce A, Littlefield
Publikováno v:
Anticancer research. 27(3B)
Laulimalide is a cytotoxic natural product isolated from marine sponges. It is structurally distinct from taxanes. However, like paclitaxel, laulimalide binds to tubulin and enhances microtubule assembly and stabilization. It exhibits potent inhibiti