Výsledky vyhledávání - "Philip S. Guzelian"

Comments on recent discussions providing differing causation methodologies

Autor: NC Halmes, Janice K. Britt, RC James, Philip S. Guzelian

Publikováno v: Human & Experimental Toxicology. 33:109-112

Recently, we and others have proposed the methods of mapping the widely accepted logic underlying evidence-based medicine (EBM) in the field of toxicology. The goal of evidence-based toxicology (EBT) is to provide a consistent, objective, and rule-ba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ef9c851b613bb67c8f4f6f35ce98f9b
https://doi.org/10.1177/0960327113491511

Zobrazit plný text záznamu

Clear path: towards an evidence-based toxicology (EBT)

Autor: Philip S. Guzelian, RC James, Victoroff, C Halmes

Publikováno v: Human & Experimental Toxicology. 28:71-79

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf7fe3b3bd4c35ea6422af46c9b92291
https://doi.org/10.1177/0960327109102802

Zobrazit plný text záznamu

Prevention of false scientific speech: a new role for an evidence-based approach

Autor: Philip S. Guzelian, Christopher P. Guzelian

Publikováno v: Human & Experimental Toxicology. 27:733-736

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a405073e6dfee15f76369e6b539bef3
https://doi.org/10.1177/0960327107084580

Zobrazit plný text záznamu

Identification of Genes Controlled by the Pregnane X Receptor by Microarray Analysis of mRNAs from Pregnenolone 16 -Carbonitrile-Treated Rats

Autor: Tzu L. Phang, Jeffrey P. Guzelian, Philip S. Guzelian, Linda C. Quattrochi, Joyce L. Barwick, Lawrence Hunter

Publikováno v: Toxicological Sciences. 94:379-387

Mammalian liver contains a pregnane X receptor (PXR, NR1I2), which binds drugs and other xenobiotics, and stimulates (or suppresses) expression of numerous genes involved in the metabolic elimination of foreign compounds and some toxic endogenous sub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cfed32584eb1a450ef493ba33acfb44
https://doi.org/10.1093/toxsci/kfl116

Zobrazit plný text záznamu

Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR)

Autor: Wen Xie, Ronald M. Evans, Joyce L. Barwick, Philip S. Guzelian, John M. Rosenfeld, Junichiro Sonoda

Publikováno v: Proceedings of the National Academy of Sciences. 99:13801-13806

The nuclear receptor PXR (pregnane X receptor) protects the body from hepatotoxicity of secondary bile acids such as lithocholic acid (LCA) by inducing expression of the hydroxylating cytochrome P450 enzyme CYP3A and promoting detoxification. We foun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::504a3adf49456b8fd65e8a3828a3b48d
https://doi.org/10.1073/pnas.212494599

Zobrazit plný text záznamu

Evidence-based toxicology: call for papers

Autor: Philip S. Guzelian

Publikováno v: Human & Experimental Toxicology. 26:5-7

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6ed2456a0a60984093be369f95a38e2
https://doi.org/10.1177/0960327107075659

Zobrazit plný text záznamu

Characterization of a Pretranscriptional Pathway for Induction by Phenobarbital of Cytochrome P450 3A23 in Primary Cultures of Adult Rat Hepatocytes

Autor: Philip S. Guzelian, Susan E.S. Brown, Linda C. Quattrochi

Publikováno v: Archives of Biochemistry and Biophysics. 342:134-142

Our laboratory has proposed that phenobarbital (PB), a typical lipophilic agent that induces some members of the supergene family of liver microsomal cytochromes P450 (e.g., CYP2B1/2 and CYP3A23), acts through a complex process inhibitable by the pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ca3bac35913e1100105d3fcefb9944
https://doi.org/10.1006/abbi.1997.0112

Zobrazit plný text záznamu

Inhibitory actions of cyclic adenosine monophosphate and pertussis toxin define two distinct epidermal growth factor-regulated pathways leading to activation of mitogen-activated protein kinase in rat hepatocytes

Autor: S. E. S. Brown, Robert W. Schrier, Raphael A. Nemenoff, Xiaomei Li, Lynn E. Heasley, Philip S. Guzelian, Pere Ginès, Toshikazu Nakamura

Publikováno v: Hepatology. 23:1167-1173

Increased intracellular cyclic adenosine monophosphate (cAMP) levels have been shown in some reports to inhibit and in other studies to stimulate growth factor-mediated activation of the mitogen-activated protein kinase (MAP kinase) pathway, dependin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c53a81b5277230999800f36f145c0e57
https://doi.org/10.1002/hep.510230535

Zobrazit plný text záznamu

Isolation of CYP3A5P cDNA from human liver: a reflection of a novel cytochrome P-450 pseudogene

Autor: Philip S. Guzelian, John D. Schuetz

Publikováno v: Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1261:161-165

We have isolated, from a human liver cDNA library, a 1627 by CYP3A5 cDNA variant ( CYP3A5P ) that contains several large insertions, deletions, and in-frame termination codons. By comparison with the genomic structure of other CYP3A genes, the major

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2a186c02c8de664e489117b32070ce2
https://doi.org/10.1016/0167-4781(95)00016-a

Zobrazit plný text záznamu

Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver

Autor: Philip S. Guzelian, Deborah L. Beach, John D. Schuetz

Publikováno v: Pharmacogenetics. 4:11-20

The human CYP3A P450 family, composed of at least four highly homologous genes, is expressed prominently in the liver. To investigate the expression of CYP3A family members individually, we prepared oligonucleotides specific for each CYP3A mRNA and u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc769db21684939d6c129006a5c7631e
https://doi.org/10.1097/00008571-199402000-00002

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání