Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Philip S Murphy"'
Autor:
Christopher Coello, Marie Fisk, Divya Mohan, Frederick J. Wilson, Andrew P. Brown, Michael I. Polkey, Ian Wilkinson, Ruth Tal-Singer, Philip S. Murphy, Joseph Cheriyan, Roger N. Gunn
Publikováno v:
EJNMMI Research, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Background An inflammatory reaction in the airways and lung parenchyma, comprised mainly of neutrophils and alveolar macrophages, is present in some patients with chronic obstructive pulmonary disease (COPD). Thoracic fluorodeoxyglucose (18F
Externí odkaz:
https://doaj.org/article/26a2b819d4a5492ab4b938385029d5bc
Autor:
Nicholas R. Livingston, Valeria Calsolaro, Rainer Hinz, Joseph Nowell, Sanara Raza, Steve Gentleman, Robin J. Tyacke, Jim Myers, Ashwin V. Venkataraman, Robert Perneczky, Roger N. Gunn, Eugenii A. Rabiner, Christine A. Parker, Philip S. Murphy, Paul B. Wren, David J. Nutt, Paul M. Matthews, Paul Edison
Publikováno v:
Molecular psychiatry 27, 2019-2029 (2022). doi:10.1038/s41380-021-01429-y
Livingston, N R, Calsolaro, V, Hinz, R, Nowell, J, Raza, S, Gentleman, S, Tyacke, R J, Myers, J, Venkataraman, A V, Perneczky, R, Gunn, R N, Rabiner, E A, Parker, C A, Murphy, P S, Wren, P B, Nutt, D J, Matthews, P M & Edison, P 2022, ' Relationship between astrocyte reactivity, using novel 11C-BU99008 PET, and glucose metabolism, grey matter volume and amyloid load in cognitively impaired individuals ', Molecular psychiatry . https://doi.org/10.1038/s41380-021-01429-y
Livingston, N R, Calsolaro, V, Hinz, R, Nowell, J, Raza, S, Gentleman, S, Tyacke, R J, Myers, J, Venkataraman, A V, Perneczky, R, Gunn, R N, Rabiner, E A, Parker, C A, Murphy, P S, Wren, P B, Nutt, D J, Matthews, P M & Edison, P 2022, ' Relationship between astrocyte reactivity, using novel 11C-BU99008 PET, and glucose metabolism, grey matter volume and amyloid load in cognitively impaired individuals ', Molecular psychiatry . https://doi.org/10.1038/s41380-021-01429-y
Post mortem neuropathology suggests that astrocyte reactivity may play a significant role in neurodegeneration in Alzheimer’s disease. We explored this in vivo using multimodal PET and MRI imaging. Twenty subjects (11 older, cognitively impaired pa
Autor:
Anna M. Hoy, Natasha McDonald, Ross J. Lennen, Matteo Milanesi, Amy H. Herlihy, Timothy J. Kendall, William Mungall, Michael Gyngell, Rajarshi Banerjee, Robert L. Janiczek, Philip S. Murphy, Maurits A. Jansen, Jonathan A. Fallowfield
Publikováno v:
Biology Open, Vol 7, Iss 7 (2018)
Non-invasive quantitation of liver disease using multiparametric magnetic resonance imaging (MRI) could refine clinical care pathways, trial design and preclinical drug development. The aim of this study was to evaluate the use of multiparametric MRI
Externí odkaz:
https://doaj.org/article/1b426a0f0e31422f831a288be36cea76
Publikováno v:
Biomarkers in Drug Discovery and Development
Publikováno v:
Biomarkers in Drug Discovery and Development
Pharmaceutical Sciences Encyclopedia
Pharmaceutical Sciences Encyclopedia
In recent years, the concept of imaging biomarkers is increasingly being utilized in drug development and for producing images of physiological and physicochemical processes in a living subject. Continuous research and development for more than 30 ye
Autor:
Steve M. Gentleman, Jim Myers, Paul Edison, David J. Nutt, Paul M. Matthews, Robin J. Tyacke, Nicholas R Livingston, Sanara Raza, Robert Perneczky, Joseph Nowell, Paul Bryan Wren, Roger N. Gunn, Ashwin V. Venkataraman, Valeria Calsolaro, Rainer Hinz, Eugenii A. Rabiner, Philip S. Murphy, Christine A. Parker
Post mortemneuropathology suggests that astrocyte reactivity may play a significant role in neurodegeneration in Alzheimer’s disease. We explored thisin vivousing multimodal PET and MRI imaging. Twenty subjects (11 older, cognitively impaired subje
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63eaa10956651dba8924b35fd70226eb
https://doi.org/10.1101/2021.08.10.21261690
https://doi.org/10.1101/2021.08.10.21261690
Autor:
Cornelius K. Donat, David J. Nutt, Magdalena Sastre, Ashwin V. Venkataraman, Jim Myers, Valeria Calsolaro, Christine A. Parker, Paul M. Matthews, Zhen Fan, Grazia Daniela Femminella, Robin J. Tyacke, Paul Bryan Wren, Nicholas R Livingston, Rainer Hinz, Sandra Silva Guedes, Paul Edison, Robert Perneczky, Roger N. Gunn, Eugenii A. Rabiner, Philip S. Murphy, Steve M. Gentleman
Publikováno v:
Calsolaro, V, Matthews, P M, Donat, C K, Livingston, N R, Femminella, G D, Guedes, S S, Myers, J, Fan, Z, Tyacke, R J, Venkataraman, A V, Perneczky, R, Gunn, R, Rabiner, E A, Gentleman, S, Parker, C A, Murphy, P S, Wren, P B, Hinz, R, Sastre, M, Nutt, D J & Edison, P 2021, ' Astrocyte reactivity with late-onset cognitive impairment assessed in vivo using 11C-BU99008 PET and its relationship with amyloid load ', Molecular psychiatry . https://doi.org/10.1038/s41380-021-01193-z
Molecular psychiatry 26(10), 5848-5855 (2021). doi:10.1038/s41380-021-01193-z
Molecular psychiatry 26(10), 5848-5855 (2021). doi:10.1038/s41380-021-01193-z
11C-BU99008 is a novel positron emission tomography (PET) tracer that enables selective imaging of astrocyte reactivity in vivo. To explore astrocyte reactivity associated with Alzheimer’s disease, 11 older, cognitively impaired (CI) subjects and 9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc52868d74bd9cf3c612cad87df19d31
https://www.research.manchester.ac.uk/portal/en/publications/astrocyte-reactivity-with-lateonset-cognitive-impairment-assessed-in-vivo-using-11cbu99008-pet-and-its-relationship-with-amyloid-load(5c4d2f0c-0e54-4620-8ec0-04dc7e769ce7).html
https://www.research.manchester.ac.uk/portal/en/publications/astrocyte-reactivity-with-lateonset-cognitive-impairment-assessed-in-vivo-using-11cbu99008-pet-and-its-relationship-with-amyloid-load(5c4d2f0c-0e54-4620-8ec0-04dc7e769ce7).html
Autor:
Nicholas R, Livingston, Valeria, Calsolaro, Rainer, Hinz, Joseph, Nowell, Sanara, Raza, Steve, Gentleman, Robin J, Tyacke, Jim, Myers, Ashwin V, Venkataraman, Robert, Perneczky, Roger N, Gunn, Eugenii A, Rabiner, Christine A, Parker, Philip S, Murphy, Paul B, Wren, David J, Nutt, Paul M, Matthews, Paul, Edison
Publikováno v:
Molecular psychiatry. 27(4)
Post mortem neuropathology suggests that astrocyte reactivity may play a significant role in neurodegeneration in Alzheimer's disease. We explored this in vivo using multimodal PET and MRI imaging. Twenty subjects (11 older, cognitively impaired pati
Autor:
Azeem Saleem, Graham E. Searle, Laura M. Kenny, Mickael Huiban, Kasia Kozlowski, Adam D. Waldman, Laura Woodley, Carlo Palmieri, Charles Lowdell, Tomomi Kaneko, Philip S. Murphy, Mike R. Lau, Eric O. Aboagye, Raoul C. Coombes
Publikováno v:
EJNMMI Research, Vol 7, Iss 1, Pp 1-1 (2017)
Externí odkaz:
https://doaj.org/article/1ed0b989b6da41e9a250e7cb531c7ba8
Autor:
Lucy E Kershaw, Alexandra R. Roberts, Rob Janiczek, Shareen Forbes, Antonella Napolitano, Andrew R Bond, Scott Semple, Pilar Jimenez-Royo, David M.L. Lilburn, Philip S. Murphy, Maurits A. Jansen, Salamah Mohammad Alwahsh
Publikováno v:
Kershaw, L E, Lilburn, D M, Jansen, M A, Bond, A R, Alwahsh, S M, Jimenez-royo, P, Napolitano, A, Murphy, P, Roberts, A, Robjaniczek,, Forbes, S & Semple, S I 2020, ' Manganese-enhanced MRI: comparison of agents in the rat pancreas ', Journal of Magnetic Resonance Open, pp. 100002 . https://doi.org/10.1016/j.jmro.2020.100002
Journal of Magnetic Resonance Open, Vol 1, Iss, Pp 100002-(2019)
Journal of Magnetic Resonance Open, Vol 1, Iss, Pp 100002-(2019)
Mangafodipir was approved for use as an MRI contrast agent in the late 1990s for liver and pancreas imaging but it was removed from the European market for commercial reasons in 2012. Previously, preliminary work in mice and in diabetic patients show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12fd339801380046b8a33199b7d9f5e9
https://www.pure.ed.ac.uk/ws/files/151369550/1_s2.0_S2666441020300029_main.pdf
https://www.pure.ed.ac.uk/ws/files/151369550/1_s2.0_S2666441020300029_main.pdf