Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Philip R. Miles"'
Autor:
Ann F. Hubbs, Jane Y. C. Ma, Philip R. Miles, Ricki L. Simoskevitz, Mark Barger, Michael L. Kashon, Mohamed Ghanem, Lori A. Battelli
Publikováno v:
Journal of Toxicology and Environmental Health, Part A. 71:521-532
Polycyclic aromatic hydrocarbons (PAHs) are products of incomplete combustion that are commonly inhaled by workers in the dusty trades. Many PAHs are metabolized by cytochrome P-4501A1 (CYP1A1), which may facilitate excretion but may activate pulmona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68f51aed1c7c7325398cb9d2dd1c86b5
https://doi.org/10.1080/15287390801907483
https://doi.org/10.1080/15287390801907483
Autor:
Linda Bowman, Ann F. Hubbs, Mark J. Reasor, Michael D. Taylor, Robert J. Mason, Kathy Shannon, Knox Van Dyke, Philip R. Miles
Publikováno v:
Toxicology and Applied Pharmacology. 167:182-190
Amiodarone (AD) is gaining support as a first-line antiarrhythmic drug despite its potentially fatal pulmonary toxicity involving inflammation and fibrosis. The goals of this study were to characterize a rat model of AD-induced pulmonary toxicity (AI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8227e99c32b02fbd934f13fe8c0bb4ae
https://doi.org/10.1006/taap.2000.9000
https://doi.org/10.1006/taap.2000.9000
Autor:
Dawn Ramsey, Jean Xiang, Dale A. Shoemaker, Nar S. Dalai, Linda Bowman, Alex W. Teass, Jack Blackford, Diane Schwegler-Berry, Jeff McLaurin, Paul A. Baron, Vincent Castranova, Donna Pack, Ann F. Hubbs, Kenneth C. Weber, Mark Barger, Amir Khan, Charles P. Childress, Jane Y. C. Ma, Val Vallyathan, Jack R. Pretty, Lloyd E. Stettler, William H. Pailes, Philip R. Miles, Richard D. Dey
Publikováno v:
Applied Occupational and Environmental Hygiene. 11:937-941
We have reported previously that grinding crystalline silica generates radicals on its cleavage planes and that this fresh dust is more cytotoxic in vitro than aged silica. The objective of the present study was to determine if freshly fractured sili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::259e87c699a8f8c733b6ad953e0ac701
https://doi.org/10.1080/1047322x.1996.10389993
https://doi.org/10.1080/1047322x.1996.10389993
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 8:597-604
Because some evidence indicates that there is an increased incidence of lung cancer in silicosis, we studied the effects of exposing rats to silica on the pulmonary microsomal cytochrome P-450 system. Rats were exposed to silica by intratracheal admi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::083b7fcb8a8789fa846fa9b70c4b087c
https://doi.org/10.1165/ajrcmb/8.6.597
https://doi.org/10.1165/ajrcmb/8.6.597
Publikováno v:
Toxicology and Applied Pharmacology. 119:142-149
Tetrandrine (TT) and other bisbenzylisoquinoline alkaloids have been used in China as a treatment for fibrotic lung diseases. Because of their potential use as pulmonary therapeutic agents, we studied the effects of some of these compounds on energy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e1c374b915a0e87bf15f768515b0eee
https://doi.org/10.1006/taap.1993.1053
https://doi.org/10.1006/taap.1993.1053
Publikováno v:
Journal of toxicology and environmental health. 49(5)
Previous studies have shown that vitamin E may be an integral part of lung surfactant and may function to protect this material from oxidant damage. Therefore, we measured the vitamin E levels in alveolar lavage materials from rats exposed to crystal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a662d4f5291850f71409c894366459ad
https://pubmed.ncbi.nlm.nih.gov/8968411
https://pubmed.ncbi.nlm.nih.gov/8968411
Publikováno v:
Experimental lung research. 21(1)
Although lethal exposures of most animal species to oxygen result in a reduced amount of surfactant phospholipids (PL), hyperoxia in rats leads to elevated levels of PL on the alveolar surface. Because of this different response, a study was made of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f8d3e11508ca5b69793abdbc15d6045
https://pubmed.ncbi.nlm.nih.gov/7729373
https://pubmed.ncbi.nlm.nih.gov/7729373
Publikováno v:
Journal of Toxicology and Environmental Health. 48:501-502
Because some evidence suggests that there may be an increased incidence of lung cancer in silicosis and because previous studies have shown that exposure of rats to silica alters the pulmonary cytochrome P-450 system, we studied the effects of exposi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a84aff5b4f8e37ad20d1f714f786d3f0
https://doi.org/10.1080/009841096161203
https://doi.org/10.1080/009841096161203
Publikováno v:
Journal of Cellular Physiology. 101:471-479
The cell volume, cell water, intracellular ionic concentrations, and transmembrane potential of rat alveolar macrophages were determined. The measurements were made on cells which had been separated from the medium by centrifugation through dibutyl p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::258dda6eb4d7638124d074831f6bbe59
https://doi.org/10.1002/jcp.1041010313
https://doi.org/10.1002/jcp.1041010313
Publikováno v:
Journal of Toxicology and Environmental Health. 8:907-915
The in vitro effects of Cd, Zn, and Pb on pulmonary, adrenal, and hepatic microsomal enzyme activities in guinea pigs were compared. Cd and Zn produced concentration-dependent (20-200 microM) decreases in benzphetamine demethylase and biphenyl hydrox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e42c78c52091ed5ce69dbc63178cb047
https://doi.org/10.1080/15287398109530125
https://doi.org/10.1080/15287398109530125