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pro vyhledávání: '"Philip Proctor"'
Publikováno v:
JAMA Network Open
Key Points Question What individual and residential characteristics are associated with COVID-19 outcomes for people with intellectual and developmental disabilities receiving residential services? Findings In this cohort study of 543 adults with int
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 2. :1213
The hydrolysis of benzylpenicillin is catalysed by alkoxide ions and other oxygen bases. Catalysis occurs by a nucleophilic pathway and the intermediate ester can be detected in some cases. The Bronsted βnuc for alkoxide ions is 0.97, and is compati
Publikováno v:
J. Chem. Soc., Perkin Trans. 2. :1725-1732
The metal(II)-ion catalysed hydrolysis of some pencillin and cephalosporin derivatives in water at 30° shows saturation kinetics. A 1 : 1 complex is formed between the metal ion and penicillin which is attacked by hydroxide ion up to 108 fold faster
Autor:
Philip Proctor, Michael I. Page
Publikováno v:
Journal of the American Chemical Society. 106:3820-3825
Le mecanisme de la reaction d'amines avec des cephalosporines n'est pas concerte mais un processus a etapes faisant intervenir la formation d'un intermediaire tetraedrique qui ensuite se decompose en produits avec peu ou pas d'assistance du groupe pa
Publikováno v:
J. Chem. Soc., Perkin Trans. 2. :1185-1192
The rates of the acid catalysed hydrolysis of penicillins and cephalosporins are linear in Ho and, unlike other amides, show no rate maximum with increasing acidity. Electron-withdrawing substituents at C-6 in penicillins decrease the rate of hydroly