Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Philip P. Paty"'
Autor:
Abhishek Jain, Montana T. Morris, Domenica Berardi, Trisha Arora, Xavier Domingo-Almenara, Philip B. Paty, Nicholas J. W. Rattray, Daniel Kerekes, Lingeng Lu, Sajid A. Khan, Caroline H. Johnson
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-9 (2024)
Abstract Objective Colorectal cancer (CRC) is conventionally classified as right sided, left sided, and rectal cancer. Clinicopathological, molecular features and risk factors do not change abruptly along the colorectum, and variations exist even wit
Externí odkaz:
https://doaj.org/article/88c40864f67f443588f8ab1802954bd9
Autor:
Yuping Cai, Xinyi Shen, Lingeng Lu, Hong Yan, Huang Huang, Patricia Gaule, Engjel Muca, Casey M. Theriot, Zahra Rattray, Nicholas J. W. Rattray, Jun Lu, Nita Ahuja, Yawei Zhang, Philip B. Paty, Sajid A. Khan, Caroline H. Johnson
Publikováno v:
Biology of Sex Differences, Vol 13, Iss 1, Pp 1-13 (2022)
Abstract Background Bile acids are known to be genotoxic and contribute to colorectal cancer (CRC). However, the link between CRC tumor bile acids to tumor location, patient sex, microbiome, immune-regulatory cells, and prognosis is not clear. Method
Externí odkaz:
https://doaj.org/article/0b5bcdaee79245478fd9882fb924ee7a
Autor:
Hong Yan, Ronan Talty, Abhishek Jain, Yuping Cai, Jie Zheng, Xinyi Shen, Engjel Muca, Philip B. Paty, Marcus W. Bosenberg, Sajid A. Khan, Caroline H. Johnson
Publikováno v:
Redox Biology, Vol 62, Iss , Pp 102699- (2023)
Aberrant tumor metabolism is a hallmark of cancer in which metabolic rewiring can support tumor growth under nutrient deficient conditions. KRAS mutations occur in 35–45% of all colorectal cancer (CRC) cases and are difficult to treat. The relation
Externí odkaz:
https://doaj.org/article/5832ba66127c4a83b04dcd182cba5e22
Autor:
Jin K. Kim, Michael R. Marco, Seo‐Hyun Choi, Xuan Qu, Chin‐Tung Chen, Moshe Elkabets, Lauren Fairchild, Oliver Chow, Francisco M. Barriga, Lukas E. Dow, Kevin O’Rourke, Bryan Szeglin, Dmitry Yarilin, Sho Fujisawa, Katia Manova‐Todorova, Philip B. Paty, Jinru Shia, Christina Leslie, J. Joshua Smith, Scott Lowe, Raphael Pelossof, Francisco Sanchez‐Vega, Julio Garcia‐Aguilar
Publikováno v:
Molecular Oncology, Vol 15, Iss 10, Pp 2766-2781 (2021)
Somatic mutations in the KRAS oncogene are associated with poor outcomes in locally advanced rectal cancer but the underlying biologic mechanisms are not fully understood. We profiled mRNA in 76 locally advanced rectal adenocarcinomas from patients t
Externí odkaz:
https://doaj.org/article/96a1e95356c241f39741faa4a5a1b2a2
Autor:
Emmanouil P. Pappou, Larissa K. Temple, Sujata Patil, J. Joshua Smith, Iris H. Wei, Garrett M. Nash, José G. Guillem, Maria Widmar, Martin R. Weiser, Philip B. Paty, Deborah Schrag, Julio Garcia-Aguilar
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Despite improvements in surgical techniques, functional outcomes and quality of life after therapy for rectal cancer remain suboptimal. We sought to prospectively evaluate the effect of bowel, bladder, and sexual functional outcomes on health-related
Externí odkaz:
https://doaj.org/article/ef006166e0254822b4c9f4bdba324667
Autor:
Stefan Klingler, Kuo-Shun Hsu, Guoqiang Hua, Maria Laura Martin, Mohammad Adileh, Timour Baslan, Zhigang Zhang, Philip B. Paty, Zvi Fuks, Anthony M.C. Brown, Richard Kolesnick
Publikováno v:
JCI Insight, Vol 7, Iss 5 (2022)
Recent data establish a logarithmic expansion of leucine rich repeat containing G protein coupled receptor 5–positive (Lgr5+) colonic epithelial stem cells (CESCs) in human colorectal cancer (CRC). Complementary studies using the murine 2-stage azo
Externí odkaz:
https://doaj.org/article/9ef3f2bee094401588a41ba8a913fa23
Autor:
Lea A. Moukarzel, Joao Casanova, José Filipe Cunha, Philip B. Paty, Emmanouil P. Pappou, Elizabeth Jewell, Dennis S. Chi
Publikováno v:
Gynecologic Oncology Reports, Vol 37, Iss , Pp 100834- (2021)
The ability to achieve complete or optimal cytoreduction in advanced or recurrent ovarian and uterine cancer is a well-established prognostic factor. Colonic resections are commonly required to achieve minimal or no residual disease. When multiple co
Externí odkaz:
https://doaj.org/article/683f840a7e654cb6aa5a0cd0d2fca2bf
Autor:
Xinyi Shen, Yuping Cai, Lingeng Lu, Huang Huang, Hong Yan, Philip B. Paty, Engjel Muca, Nita Ahuja, Yawei Zhang, Caroline H. Johnson, Sajid A. Khan
Publikováno v:
Metabolites, Vol 12, Iss 2, p 164 (2022)
The interplay between the sex-specific differences in tumor metabolome and colorectal cancer (CRC) prognosis has never been studied and represents an opportunity to improve patient outcomes. This study examines the link between tumor metabolome and p
Externí odkaz:
https://doaj.org/article/5c09259c151d43ceb4e824dc27e3684e
Autor:
Norihiro Yamaguchi, Ethan M Weinberg, Alexander Nguyen, Maria V Liberti, Hani Goodarzi, Yelena Y Janjigian, Philip B Paty, Leonard B Saltz, T Peter Kingham, Jia Min Loo, Elisa de Stanchina, Sohail F Tavazoie
Publikováno v:
eLife, Vol 8 (2019)
Colorectal cancer (CRC) is a major cause of human death. Mortality is primarily due to metastatic organ colonization, with the liver being the main organ affected. We modeled metastatic CRC (mCRC) liver colonization using patient-derived primary and
Externí odkaz:
https://doaj.org/article/df6349d3163c42688775653c831ce857
Autor:
Yuping Cai, Nicholas J. W. Rattray, Qian Zhang, Varvara Mironova, Alvaro Santos-Neto, Engjel Muca, Ana K. Rosen Vollmar, Kuo-Shun Hsu, Zahra Rattray, Justin R. Cross, Yawei Zhang, Philip B. Paty, Sajid A. Khan, Caroline H. Johnson
Publikováno v:
Metabolites, Vol 10, Iss 6, p 257 (2020)
The progress in the discovery and validation of metabolite biomarkers for the detection of colorectal cancer (CRC) has been hampered by the lack of reproducibility between study cohorts. The majority of discovery-phase biomarker studies have used pat
Externí odkaz:
https://doaj.org/article/7558683f9e2d443984d86bc326724df5