Výsledky vyhledávání - "Philip O. Livingston"

Data from Human Monoclonal Antibodies to Sialyl-Lewisa (CA19.9) with Potent CDC, ADCC, and Antitumor Activity

Autor: Wolfgang W. Scholz, Philip O. Livingston, Govind Ragupathi, Feng Hong, Xiaohong Wu, Shu-Man Sun, Ritsuko Sawada

Purpose: The carbohydrate antigen sialyl-Lewisa (sLea), also known as CA19.9, is widely expressed on epithelial tumors of the gastrointestinal tract and breast and on small-cell lung cancers. Since overexpression of sLea appears to be a key event in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70001bbc550e6ccd97b2b14809567927
https://doi.org/10.1158/1078-0432.c.6520268

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Data from Accelerated Tumor Growth Mediated by Sublytic Levels of Antibody-Induced Complement Activation Is Associated with Activation of the PI3K/AKT Survival Pathway

Autor: Philip O. Livingston, Feng Hong, Katherine Panageas, Govind Ragupathi, Xiaohong Wu

Purpose: We addressed the possibility that low levels of tumor cell-bound antibodies targeting gangliosides might accelerate tumor growth.Experimental Design: To test this hypothesis, we treated mice with a range of monoclonal antibody (mAb) doses ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f7deedbc0391508d07cd87076b4933a
https://doi.org/10.1158/1078-0432.c.6520820

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Supplementary Figure A from Accelerated Tumor Growth Mediated by Sublytic Levels of Antibody-Induced Complement Activation Is Associated with Activation of the PI3K/AKT Survival Pathway

Autor: Philip O. Livingston, Feng Hong, Katherine Panageas, Govind Ragupathi, Xiaohong Wu

Supplementary Figure B - PDF file 42K, CHLA136Luc or H524 cells treated with Human sera Complement (HuC') or heat inactivated HuC'(De-HuC') with or without the mAbs (3F8, PGNX and R24) for overnight. De- HuC' was achieved by heating the human complem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7445722510c0953499443171ca7be84f
https://doi.org/10.1158/1078-0432.22446668

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Applying PET to Broaden the Diagnostic Utility of the Clinically Validated CA19.9 Serum Biomarker for Oncology

Autor: Nerissa Viola-Villegas, Marija Drobjnak, Ritsuko Sawada, Govind Ragupathi, Kuntal K. Sevak, Michael J. Evans, Philip O. Livingston, Jason S. Lewis, Samuel L. Rice, Sean Carlin, Xiaohong Wu, Wolfgang W. Scholz

Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine, vol 54, iss 11

UnlabelledDespite their considerable advantages, many circulating biomarkers have well-documented limitations. One prominent shortcoming in oncology is a high frequency of false-positive indications for malignant disease in upfront diagnosis. Because

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7e656ab514a61791906761e9a09471c
https://doi.org/10.2967/jnumed.113.119867

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Accelerated Tumor Growth Mediated by Sublytic Levels of Antibody-Induced Complement Activation Is Associated with Activation of the PI3K/AKT Survival Pathway

Autor: Katherine S. Panageas, Govind Ragupathi, Xiaohong Wu, Philip O. Livingston, Feng Hong

Publikováno v: Clinical Cancer Research. 19:4728-4739

Purpose: We addressed the possibility that low levels of tumor cell-bound antibodies targeting gangliosides might accelerate tumor growth. Experimental Design: To test this hypothesis, we treated mice with a range of monoclonal antibody (mAb) doses a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e85b67a6d464132a15993f57175f61c4
https://doi.org/10.1158/1078-0432.ccr-13-0088

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Immunization with N-propionyl polysialic acid–KLH conjugate in patients with small cell lung cancer is safe and induces IgM antibodies reactive with SCLC cells and bactericidal against group B meningococci

Autor: Lauren E. Abrey, Lee M. Krug, Govind Ragupathi, Harold J. Jennings, Ronglai Shen, Chandra Hood, Constantine George, Philip O. Livingston, Feng Hong, Mark G. Kris

Publikováno v: Cancer Immunology, Immunotherapy. 61:9-18

Polysialic acid (polySA) is a polymer side chain bound to the neural cell adhesion molecule that is extensively expressed on the surface of small cell lung cancer (SCLC) cells. In our previous study, a robust antibody response was noted in patients w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44bff6ae904086d2d8a71c2b4dd820cd
https://doi.org/10.1007/s00262-011-1083-6

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