Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Philip Nunn"'
Autor:
Sibel Ucpinar, Patrick F. Smith, Li Long, Fujun Li, Hui Yan, Jyoti Wadhwa, Katherine A. Chu, Jin Shu, Philip Nunn, Mengyao Li
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 7, Pp 1210-1219 (2023)
Abstract This single‐center, open‐label, non‐randomized, two‐part, phase I study was conducted (1) to evaluate the absolute oral bioavailability of rilzabrutinib 400 mg tablet following an i.v. microtracer dose of ~100 μg [14C]‐rilzabrutin
Externí odkaz:
https://doaj.org/article/e8f901b053fc4c77b57444a1f51b046f
Autor:
Sibel Ucpinar, Borje Darpo, Ann Neale, Philip Nunn, Jin Shu, Katherine A. Chu, Marianne Kavanagh, Hongqi Xue, Pasit Phiasivongsa, Dolca Thomas, Patrick F. Smith
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 6, Pp 1507-1518 (2022)
Abstract This study aimed to define the clinically relevant supratherapeutic dose of rilzabrutinib, an oral Bruton tyrosine kinase (BTK) inhibitor, and evaluate potential effects of therapeutic and supratherapeutic exposures on cardiac repolarization
Externí odkaz:
https://doaj.org/article/3418278264b64f71bc273037eb1ad05f
Autor:
Timothy D. Owens, Ken A. Brameld, Erik J. Verner, Tony Ton, Xiaoyan Li, Jiang Zhu, Mohammad R. Masjedizadeh, J. Michael Bradshaw, Ronald J. Hill, Danny Tam, Angelina Bisconte, Eun Ok Kim, Michelle Francesco, Yan Xing, Jin Shu, Dane Karr, Jacob LaStant, David Finkle, Natalie Loewenstein, Helena Haberstock-Debic, Michael J. Taylor, Philip Nunn, Claire L. Langrish, David M. Goldstein
Publikováno v:
Journal of medicinal chemistry. 65(7)
Bruton's tyrosine kinase (BTK), a Tec family tyrosine kinase, is critical in immune pathways as an essential intracellular signaling element, participating in both adaptive and immune responses. Currently approved BTK inhibitors are irreversible cova
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::288f1908751aebe6ff2c56fdf8695ab7
https://pubmed.ncbi.nlm.nih.gov/35302767
https://pubmed.ncbi.nlm.nih.gov/35302767
Publikováno v:
British Journal of Pharmacology. 136:399-414
The effects of L-NAME and zaprinast were investigated (i.v.) on reflex-evoked changes in bladder and urethral pressures in urethane-anaesthetized female rats. L-NAME attenuated reflex-evoked urethral relaxations (65±10%), while zaprinast potentiated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa4a85d7630d970ecb18485bfea64847
https://doi.org/10.1038/sj.bjp.0704735
https://doi.org/10.1038/sj.bjp.0704735
Autor:
Kieran Philip, Nunn, Peter K, Thompson
Publikováno v:
Emergency medicine journal : EMJ. 28(9)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::937bb4caa55dd51d5662d5fc57d991a7
https://pubmed.ncbi.nlm.nih.gov/21857000
https://pubmed.ncbi.nlm.nih.gov/21857000
Autor:
Waleed, Danho, Joseph, Swistok, Wajiha, Khan, Xin-Jie, Chu, Adrian, Cheung, David, Fry, Hongmao, Sun, Grazyna, Kurylko, Leonid, Rumennik, Joseph, Cefalu, Gretchen, Cefalu, Philip, Nunn
Publikováno v:
Advances in experimental medicine and biology. 611
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6b2447a32d2ba5d4340687d9c4298120
https://pubmed.ncbi.nlm.nih.gov/19400268
https://pubmed.ncbi.nlm.nih.gov/19400268
Autor:
David C. Fry, Joseph S. Cefalu, Gretchen Cefalu, Chu Xin-Jie, Leonid Rumennik, Hongmao Sun, Philip Nunn, Grazyna Kurylko, Wajiha Khan, Adrian Wai-Hing Cheung, Joseph Swistok, Waleed Danho
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9780387736563
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d408fb313e8f612420fcfef4aea2c273
https://doi.org/10.1007/978-0-387-73657-0_201
https://doi.org/10.1007/978-0-387-73657-0_201
Autor:
Debra A, Cockayne, Philip M, Dunn, Yu, Zhong, Weifang, Rong, Sara G, Hamilton, Gillian E, Knight, Huai-Zhen, Ruan, Bei, Ma, Ping, Yip, Philip, Nunn, Stephen B, McMahon, Geoffrey, Burnstock, Anthony P D W, Ford
Publikováno v:
The Journal of physiology. 567(Pt 2)
Extracellular ATP plays a role in nociceptive signalling and sensory regulation of visceral function through ionotropic receptors variably composed of P2X2 and P2X3 subunits. P2X2 and P2X3 subunits can form homomultimeric P2X2, homomultimeric P2X3, o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f9d89740907ba1d67ef1e6e1c167d434
https://pubmed.ncbi.nlm.nih.gov/15961431
https://pubmed.ncbi.nlm.nih.gov/15961431
Publikováno v:
Current Protocols in Pharmacology
This unit describes a model system for the measurement of the effects of compounds on bladder function in anesthetized dog and rat. A protocol is also described for measuring nerve-stimulated salivary secretion which is particularly relevant when inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::667402b71d831b049354ec595d0c11ea
https://doi.org/10.1002/0471141755.ph0511s02
https://doi.org/10.1002/0471141755.ph0511s02