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Autor:
Philip N. Vrkljan, Kenneth E. Neet, Mark Solc, Gail Lawrance, Igor L. Shamovsky, Richard J. Riopelle, Joan I. Post, Suzanne M. Dostaler, Gregory M. Ross, Sang B. Woo
Publikováno v:
Journal of Neurochemistry. 78:515-523
It has recently been shown that transition metal cations Zn2+ and Cu2+ bind to histidine residues of nerve growth factor (NGF) and other neurotrophins (a family of proteins important for neuronal survival) leading to their inactivation. Experimental