Výsledky vyhledávání - "Philip N. Moquist"

Chiral Amino Alcohols via Catalytic Enantioselective Petasis Borono-Mannich Reactions

Autor: John Kavouris, Roman Demerzhan, Philip N. Moquist, Kathryn Kavouris, Mathew J. Vetticatt, Victor Wambua, Scott E. Schaus

Chiral amino alcohols are valuable building blocks in the synthesis of drugs, natural products, and chiral ligands used in enantioselective catalysis. The Petasis borono-Mannich reaction is a multicomponent condensation reaction of aldehydes, amines,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e9be6061e550c17234b01fd2adf3acb
https://doi.org/10.26434/chemrxiv.12479654.v1

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High-Throughput Screen in Cryptococcus neoformans Identifies a Novel Molecular Scaffold That Inhibits Cell Wall Integrity Pathway Signaling

Autor: Stuart L. Schreiber, Philip N. Moquist, Michelle Palmer, Louis DiDone, Jun Pu, Sivaraman Dandapani, Damian J. Krysan, Kate Hartland, Benito Munoz

Publikováno v: ACS Infectious Diseases

Cryptococcus neoformans is one of the most important human fungal pathogens; however, no new therapies have been developed in over 50 years. Fungicidal activity is crucially important for an effective anticryptococal agent and, therefore, we screened

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc67c8bad144fc0b5f0432fa3cfb3beb
http://europepmc.org/articles/PMC4709821

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Enantioselective Boronate Additions to N-Acyl Quinoliniums Catalyzed by Tartaric Acid

Autor: Scott E. Schaus, Tomohiro Kodama, Philip N. Moquist

Publikováno v: Organic Letters. 13:6316-6319

Tartaric acid catalyzes the asymmetric addition of vinylboronates to N-acyl quinoliniums, affording highly enantioenriched dihydroquinolines. The catalyst serves to activate the boronate through a ligand-exchange reaction and generates the N-acyl qui

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b35eead4bccdb17e8c25bce19c47a5e
https://doi.org/10.1021/ol2028702

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Catalytic Diastereoselective Petasis Reactions

Autor: Philip N. Moquist, Scott E. Schaus, Stuart L. Schreiber, Giovanni Muncipinto

Publikováno v: Angewandte Chemie. 123:8322-8325

The Petasis boronic acid Mannich reaction is a versatile multicomponent reaction of boronic acids, amines and aldehydes that generates highly functionalized α-amino acids and β-amino alcohols.[1] When enantiopure α-hydroxy aldehyde derivatives are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33738a66a510a53f5553d3dddc0d2367
https://doi.org/10.1002/ange.201103271

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Enantioselective Addition of Boronates to Chromene Acetals Catalyzed by a Chiral Brønsted Acid/Lewis Acid System

Autor: Scott E. Schaus, Philip N. Moquist, Tomohiro Kodama

Publikováno v: Angewandte Chemie International Edition. 49:7096-7100

Chiral α,β-dihydroxy carboxylic acids catalyze the enantioselective addition of alkenyl- and aryl boronates to chromene acetals. The optimal carboxylic acid is a tartaric acid amide, easily synthesized via a 3-step procedure. The reaction is enhanc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47d589fd8e9d3624fe9394f16f7910b6
https://doi.org/10.1002/anie.201003469

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Abstract 2803: Novel auristatins with high activity on efflux-positive models and demonstrable bystander activity

Autor: Robert P. Lyon, Marsha Quick, Philip N. Moquist, Andrew B. Waight, Sarah Owen, Tim D. Bovee, Sharsti Sandall, Svetlana O. Doronina, Margo Zaval, Jamie A. Mitchell, Nicole Blesie, Peter D. Senter, Kim K. Emmerton

Publikováno v: Cancer Research. 78:2803-2803

Auristatins are a class of clinically validated antimitotic agents utilized as payloads in antibody-drug conjugates (ADCs). Auristatins display many of the desirable properties necessary for ADC cytotoxins, such as low nanomolar potency, cell permeab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74dfb56287792bb70b6288ba623865d8
https://doi.org/10.1158/1538-7445.am2018-2803

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Asymmetric Allylboration of Acyl Imines Catalyzed by Chiral Diols

Autor: Sha Lou, Scott E. Schaus, Philip N. Moquist

Publikováno v: Journal of the American Chemical Society. 129:15398-15404

Chiral BINOL-derived diols catalyze the enantioselective asymmetric allylboration of acyl imines. The reaction requires 15 mol % (S)-3,3‘-Ph2-BINOL as the catalyst and allyldiisopropoxyborane as the nucleophile. The reaction products are obtained i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad97e0f4d9682cf488cf8d9755566b0
https://doi.org/10.1021/ja075204v

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ChemInform Abstract: Enantioselective Synthesis of 1,2-Dihydronaphthalene-1-carbaldehydes by Addition of Boronates to Isochromene Acetals Catalyzed by Tartaric Acid

Autor: Tomohiro Kodama, Keith S. Barbato, Philip N. Moquist, Yi Luan, Scott E. Schaus

Publikováno v: ChemInform. 46

A novel [4 + 2] cycloaddition to synthesize the title compounds bearing two chiral centers with high enantio- and diastereoselectivity is developed using the coupling reaction of isochromene acetals (I) with alkenyl boronates.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14fbc5723c887b33db97d8f25c6c4a8c
https://doi.org/10.1002/chin.201534027

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