Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Philip N Ward"'
Autor:
Joseph JE Caesar, Hayley Lavender, Philip N Ward, Rachel M Exley, Jack Eaton, Emily Chittock, Talat H Malik, Elena Goiecoechea De Jorge, Matthew C Pickering, Christoph M Tang, Susan M Lea
Publikováno v:
eLife, Vol 3 (2014)
Genome-wide association studies have found variation within the complement factor H gene family links to host susceptibility to meningococcal disease caused by infection with Neisseria meningitidis (Davila et al., 2010). Mechanistic insights have bee
Externí odkaz:
https://doaj.org/article/70bd75d9cb164b2881f476352ff38940
Autor:
Steven Johnson, Lionel Tan, Stijn van der Veen, Joseph Caesar, Elena Goicoechea De Jorge, Rachel J Harding, Xilian Bai, Rachel M Exley, Philip N Ward, Nicola Ruivo, Kaushali Trivedi, Elspeth Cumber, Rhian Jones, Luke Newham, David Staunton, Rafael Ufret-Vincenty, Ray Borrow, Matthew C Pickering, Susan M Lea, Christoph M Tang
Publikováno v:
PLoS Pathogens, Vol 8, Iss 10, p e1002981 (2012)
Neisseria meningitis remains a leading cause of sepsis and meningitis, and vaccines are required to prevent infections by this important human pathogen. Factor H binding protein (fHbp) is a key antigen that elicits protective immunity against the men
Externí odkaz:
https://doaj.org/article/be29726a5dda472eba006fbddaa7e68a
Autor:
Matthew T G Holden, Heidi Hauser, Mandy Sanders, Thi Hoa Ngo, Inna Cherevach, Ann Cronin, Ian Goodhead, Karen Mungall, Michael A Quail, Claire Price, Ester Rabbinowitsch, Sarah Sharp, Nicholas J Croucher, Tran Bich Chieu, Nguyen Thi Hoang Mai, To Song Diep, Nguyen Tran Chinh, Michael Kehoe, James A Leigh, Philip N Ward, Christopher G Dowson, Adrian M Whatmore, Neil Chanter, Pernille Iversen, Marcelo Gottschalk, Josh D Slater, Hilde E Smith, Brian G Spratt, Jianguo Xu, Changyun Ye, Stephen Bentley, Barclay G Barrell, Constance Schultsz, Duncan J Maskell, Julian Parkhill
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6072 (2009)
BACKGROUND:Streptococcus suis is a zoonotic pathogen that infects pigs and can occasionally cause serious infections in humans. S. suis infections occur sporadically in human Europe and North America, but a recent major outbreak has been described in
Externí odkaz:
https://doaj.org/article/d0cf175f60c743c58c9ef9e4def64ac4
Autor:
Miriam Weckener, Laura S. Woodward, Bradley R. Clarke, Huanting Liu, Philip N. Ward, Audrey Le Bas, David Bhella, Chris Whitfield, James H. Naismith
Publikováno v:
Open Biology, Vol 13, Iss 3 (2023)
The enterobacterial common antigen (ECA) is a carbohydrate polymer that is associated with the cell envelope in the Enterobacteriaceae. ECA contains a repeating trisaccharide which is polymerized by WzyE, a member of the Wzy membrane protein polymera
Externí odkaz:
https://doaj.org/article/19c5542dd1c9491aa5e65f1ae1097f02
Autor:
Jiandong Huo, Halina Mikolajek, Audrey Le Bas, Jordan J. Clark, Parul Sharma, Anja Kipar, Joshua Dormon, Chelsea Norman, Miriam Weckener, Daniel K. Clare, Peter J. Harrison, Julia A. Tree, Karen R. Buttigieg, Francisco J. Salguero, Robert Watson, Daniel Knott, Oliver Carnell, Didier Ngabo, Michael J. Elmore, Susan Fotheringham, Adam Harding, Lucile Moynié, Philip N. Ward, Maud Dumoux, Tessa Prince, Yper Hall, Julian A. Hiscox, Andrew Owen, William James, Miles W. Carroll, James P. Stewart, James H. Naismith, Raymond J. Owens
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Neutralizing nanobodies (Nb) are of considerable interest as therapeutic agents for COVID-19 treatment. Here, the authors functionally and structurally characterize Nbs that bind with high affinity to the receptor binding domain of the SARS-CoV-2 spi
Externí odkaz:
https://doaj.org/article/d505e344aed84336a3d7f7d369c5238a
Autor:
Yun Yang, Jiwei Liu, Bradley R. Clarke, Laura Seidel, Jani R. Bolla, Philip N. Ward, Peijun Zhang, Carol V. Robinson, Chris Whitfield, James H. Naismith
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The Wzc–Wza complex forms part of the bacterial extracellular polysaccharides synthesis machinery, where cycling of the Wzc between phosphorylation states is crucial to both synthesis and export. Here the authors report the structure of the Wzc oct
Externí odkaz:
https://doaj.org/article/953375ccf8f24a0f97419d2d1888d0c0
Autor:
Robert J. Watson, Oliver Carnell, Jordan J. Clark, Francisco J. Salguero, Tessa Prince, William James, Michael J. Elmore, Miriam Weckener, Philip N. Ward, Audrey Le Bas, Chelsea Norman, Susan A. Fotheringham, Raymond J. Owens, Yper Hall, Parul Sharma, James H. Naismith, Adam Harding, Karen R. Buttigieg, Andrew Owen, Peter J. Harrison, Lucile Moynié, Jiandong Huo, Anja Kipar, Miles W. Carroll, Daniel K. Clare, James P. Stewart, Didier Ngabo, H. Mikolajek, Daniel Knott, Maud Dumoux, Joshua Dormon, Julia A. Tree, Julian A. Hiscox
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications
SARS-CoV-2 remains a global threat to human health particularly as escape mutants emerge. There is an unmet need for effective treatments against COVID-19 for which neutralizing single domain antibodies (nanobodies) have significant potential. Their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88bfe2f67b6c2ee50cd8f27682defac4
https://doaj.org/article/d505e344aed84336a3d7f7d369c5238a
https://doaj.org/article/d505e344aed84336a3d7f7d369c5238a
Autor:
Halina Mikolajek, Miriam Weckener, Z. Faidon Brotzakis, Jiandong Huo, Evmorfia V. Dalietou, Audrey Le Bas, Pietro Sormanni, Peter J. Harrison, Philip N. Ward, Steven Truong, Lucile Moynie, Daniel K. Clare, Maud Dumoux, Joshua Dormon, Chelsea Norman, Naveed Hussain, Vinod Vogirala, Raymond J. Owens, Michele Vendruscolo, James H. Naismith
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(31)
Camelid single-domain antibodies, also known as nanobodies, can be readily isolated from naïve libraries for specific targets but often bind too weakly to their targets to be immediately useful. Laboratory-based genetic engineering methods to enhanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b811107a3bdaaf5ddc1b250705ac6e1
https://pubmed.ncbi.nlm.nih.gov/35858383
https://pubmed.ncbi.nlm.nih.gov/35858383
Autor:
Sergio Daga, Alessandra Renieri, Philip N. Ward, Simone Furini, Lachlan P. Deimel, Raymond J. Owens, Alexandre M. J. J. Bonvin, Francesca Fava, Jiwei Liu, Georgios Papadakis, Kapil Gupta, Marco Gori, Quentin J. Sattentau, Margherita Baldassarri, Aziz Khan, Andrew Baldwin, Elisa Benetti, Gen-Covid Multicenter Study, Ben Gaunt, Christiane Schaffitzel, Yun Yang, Jiandong Huo, Maud Dumoux, Charles J. Buchanan, Benjamin G. Davis, Andrew M. Giltrap, Virginia Casablancas-Antras, Panagiotis I. Koukos, Peter J. Harrison, Annarita Giliberti, Abirami Lakshminarayanan, Xiaochao Xue, Nicola Picchiotti, Chiara Fallerini, Timothy D. W. Claridge, Imre Berger, Audrey Le Bas, James H. Naismith
Many host pathogen interactions such as human viruses (including non-SARS-coronaviruses) rely on attachment to host cell-surface glycans. There are conflicting reports about whether the Spike protein of SARS-CoV-2 binds to sialic acid commonly found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aae057b82835829fd011b653b1c2b7d1
https://doi.org/10.1101/2021.04.14.439284
https://doi.org/10.1101/2021.04.14.439284
Autor:
Alexandre Wohlkonig, Hugues Nury, Baptiste Fischer, Tomasz Uchański, Eleftherios Zarkadas, Philip N. Ward, Thomas Zögg, Wim F. Vranken, Uriel López-Sánchez, Han Remaut, Jan Steyaert, S. Masiulis, A. Radu Aricescu, Valentina Kalichuk, Els Pardon, Andrija Sente, Miriam Weckener, James H. Naismith
Publikováno v:
Nat Methods
Nature Methods
Nature Methods, Nature Publishing Group, 2021, 18 (1), pp.60-68. ⟨10.1038/s41592-020-01001-6⟩
Nature Methods
Nature Methods, Nature Publishing Group, 2021, 18 (1), pp.60-68. ⟨10.1038/s41592-020-01001-6⟩
Nanobodies are popular and versatile tools for structural biology. They have a compact single immunoglobulin domain organization, bind target proteins with high affinities while reducing their conformational heterogeneity and stabilize multi-protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17a20b1fa8cb10664dbf74b70ec96717
https://hdl.handle.net/20.500.14017/ecc7ac52-bf79-404b-a10c-376958b75a75
https://hdl.handle.net/20.500.14017/ecc7ac52-bf79-404b-a10c-376958b75a75