UBC-Nepal Expedition: An experimental overview of the 2016 University of British Columbia Scientific Expedition to Nepal Himalaya.

Autor: Christopher K Willie, Michael Stembridge, Ryan L Hoiland, Michael M Tymko, Joshua C Tremblay, Alexander Patrician, Craig Steinback, Jonathan Moore, James Anholm, Prajan Subedi, Shailesh Niroula, Chris J McNeil, Ali McManus, David B MacLeod, Philip N Ainslie

Publikováno v: PLoS ONE, Vol 13, Iss 10, p e0204660 (2018)

The University of British Columbia Nepal Expedition took place over several months in the fall of 2016 and was comprised of an international team of 37 researchers. This paper describes the objectives, study characteristics, organization and manageme

Externí odkaz: https://doaj.org/article/4cca0ba07d064427bc8c651c3a6e9de1

Cerebral blood flow and cerebrovascular reactivity are modified by maturational stage and exercise training status during youth

Autor: Jack S. Talbot, Dean R. Perkins, Christine M. Tallon, Tony G. Dawkins, Andrew J. M. Douglas, Ryan Beckerleg, Andrew Crofts, Melissa E. Wright, Saajan Davies, Jessica J. Steventon, Kevin Murphy, Rachel N. Lord, Christopher J. A. Pugh, Jon L. Oliver, Rhodri S. Lloyd, Philip N. Ainslie, Ali M. McManus, Mike Stembridge

Publikováno v: Experimental Physiology, Vol 108, Iss 12, Pp 1500-1515 (2023)

Abstract Global cerebral blood flow (gCBF) and cerebrovascular reactivity to hypercapnia (CVRCO2) are modulated by gonadal hormone activity, while insulin‐like growth factor 1 facilitates exercise‐mediated cerebral angiogenesis in adults. Whether

Externí odkaz: https://doaj.org/article/20b61a3e79984408bcdf31f2b7030741

Pulmonary vascular reactivity to supplemental oxygen in Sherpa and lowlanders during gradual ascent to high altitude

Autor: Prajan Subedi, Christopher Gasho, Michael Stembridge, Alexandra M. Williams, Alexander Patrician, Philip N. Ainslie, James D. Anholm

Publikováno v: Experimental Physiology, Vol 108, Iss 1, Pp 111-122 (2023)

Abstract Prolonged alveolar hypoxia leads to pulmonary vascular remodelling. We examined the time course at altitude, over which hypoxic pulmonary vasoconstriction goes from being acutely reversible to potentially irreversible. Study subjects were lo

Externí odkaz: https://doaj.org/article/14c45d9702594740a9d007e981f1c48d

Human total, basal and activity energy expenditures are independent of ambient environmental temperature

Autor: Xueying Zhang, Yosuke Yamada, Hiroyuki Sagayama, Philip N. Ainslie, Ellen E. Blaak, Maciej S. Buchowski, Graeme L. Close, Jamie A. Cooper, Sai Krupa Das, Lara R. Dugas, Michael Gurven, Asmaa El Hamdouchi, Sumei Hu, Noorjehan Joonas, Peter Katzmarzyk, William E. Kraus, Robert F. Kushner, William R. Leonard, Corby K. Martin, Erwin P. Meijer, Marian L. Neuhouser, Robert M. Ojiambo, Yannis P. Pitsiladis, Guy Plasqui, Ross L. Prentice, Susan B. Racette, Eric Ravussin, Leanne M. Redman, Rebecca M. Reynolds, Susan B. Roberts, Luis B. Sardinha, Analiza M. Silva, Eric Stice, Samuel S. Urlacher, Edgar A. Van Mil, Brian M. Wood, Alexia J. Murphy-Alford, Cornelia Loechl, Amy H. Luke, Jennifer Rood, Dale A. Schoeller, Klaas R. Westerterp, William W. Wong, Herman Pontzer, John R. Speakman, Lene F. Andersen, Liam J. Anderson, Lenore Arab, Issad Baddou, Bedu Addo, Stephane Blanc, Alberto Bonomi, Carlijn V.C. Bouten, Pascal Bovet, Stefan Branth, Niels C. De Bruin, Nancy F. Butte, Lisa H. Colbert, Stephan G. Camps, Alice E. Dutman, Simon D. Eaton, Ulf Ekelund, Sonja Entringer, Cara Ebbeling, Sölve Elmståhl, Mikael Fogelholm, Terrence Forrester, Barry W. Fudge, Tamara Harris, Rik Heijligenberg, Annelies H. Goris, Catherine Hambly, Marije B. Hoos, Hans U. Jorgensen, Annemiek M. Joosen, Kitty P. Kempen, Misaka Kimura, Watanee Kriengsinyos, Estelle V. Lambert, Christel L. Larsson, Nader Lessan, David S. Ludwig, Margaret McCloskey, Anine C. Medin, Gerwin A. Meijer, Eric Matsiko, Alida Melse-Boonstra, James C. Morehen, James P. Morton, Theresa A. Nicklas, Daphne L. Pannemans, Kirsi H. Pietiläinen, Renaat M. Philippaerts, Roberto A. Rabinovich, John J. Reilly, Elisabet M. Rothenberg, Albertine J. Schuit, Sabine Schulz, Anders M. Sjödin, Amy Subar, Minna Tanskanen, Ricardo Uauy, Giulio Valenti, Ludo M. Van Etten, Rita Van den Berg-Emons, Wim G. Van Gemert, Erica J. Velthuis-te Wierik, Wilhelmine W. Verboeket-van de Venne, Jeanine A. Verbunt, Jonathan C.K. Wells, George Wilson

Publikováno v: iScience, Vol 25, Iss 8, Pp 104682- (2022)

Summary: Lower ambient temperature (Ta) requires greater energy expenditure to sustain body temperature. However, effects of Ta on human energetics may be buffered by environmental modification and behavioral compensation. We used the IAEA DLW databa

Externí odkaz: https://doaj.org/article/185d20235c154c7c8514e8e72ad6ab8c

Adrenergic control of skeletal muscle blood flow during chronic hypoxia in healthy males

Autor: Lydia L. Simpson, Alexander B. Hansen, Gilbert Moralez, Sachin B. Amin, Florian Hofstaetter, Christopher Gasho, Mike Stembridge, Tony G. Dawkins, Michael M. Tymko, Philip N. Ainslie, Justin S. Lawley, Christopher M. Hearon

Publikováno v: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 324:R457-R469

Sympathetic transduction is reduced following chronic high-altitude (HA) exposure; however, vascular α-adrenergic signaling, the primary mechanism mediating sympathetic vasoconstriction at sea level (SL), has not been examined at HA. In nine male lo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a9b62085750b6f64476bab0732909f3
https://doi.org/10.1152/ajpregu.00230.2022