Zobrazeno 1 - 10
of 274
pro vyhledávání: '"Philip N, Tsichlis"'
Autor:
Alessandro La Ferlita, Salvatore Alaimo, Giovanni Nigita, Rosario Distefano, Joal D. Beane, Philip N. Tsichlis, Alfredo Ferro, Carlo M. Croce, Alfredo Pulvirenti
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108810- (2024)
Summary: tRNA-derived ncRNAs are a heterogeneous class of non-coding RNAs recently proposed to be active regulators of gene expression and be involved in many diseases, including cancer. Consequently, several online resources on tRNA-derived ncRNAs h
Externí odkaz:
https://doaj.org/article/df8d8d9b250e4871b51ccf310172e060
Autor:
Apostolia-Maria Tsimberidou, Antonis Skliris, Alan Valentine, Jamie Shaw, Ursula Hering, Henry Hiep Vo, Tung On Chan, Roger S. Armen, Jeffrey R. Cottrell, Jen Q. Pan, Philip N. Tsichlis
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Background Changes in the expression and activity of the AKT oncogene play an important role in psychiatric disease. We present translational data assessing the role of AKT in psychiatric symptoms. Methods (1) We assessed the protein activit
Externí odkaz:
https://doaj.org/article/db571bc65b8444c39720d8f1d6ebe5cd
Autor:
Georgios I. Laliotis, Adam D. Kenney, Evangelia Chavdoula, Arturo Orlacchio, Abdul Kaba, Alessandro La Ferlita, Vollter Anastas, Christos Tsatsanis, Joal D. Beane, Lalit Sehgal, Vincenzo Coppola, Jacob S. Yount, Philip N. Tsichlis
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Laliotis et al. examine the role of the AKT3-phoshorylated RNA processing factor IWS1 and the IWS1 phosphorylation-dependent alternative splicing of U2AF2 in lung adenocarcinoma cells. The alternatively spliced variant of U2AF2 regulates the nuclear
Externí odkaz:
https://doaj.org/article/4976aacb26fc469e84b6096ba7b23887
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Akt is a PI3K-activated serine-threonine kinase that exists in three distinct isoforms. Akt’s expression in most immune cells, either at baseline or upon activation, reflects its importance in the immune system. While Akt is most highly expressed i
Externí odkaz:
https://doaj.org/article/ed1c0cae6a8e4117bb2d5e49302d3186
Autor:
Georgios I. Laliotis, Evangelia Chavdoula, Maria D. Paraskevopoulou, Abdul Kaba, Alessandro La Ferlita, Satishkumar Singh, Vollter Anastas, Keith A. Nair, Arturo Orlacchio, Vasiliki Taraslia, Ioannis Vlachos, Marina Capece, Artemis Hatzigeorgiou, Dario Palmieri, Christos Tsatsanis, Salvatore Alaimo, Lalit Sehgal, David P. Carbone, Vincenzo Coppola, Philip N. Tsichlis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-25 (2021)
IWS1 regulates multiple steps in RNA metabolism, including RNA elongation and alternative RNA splicing. Here the authors show that AKT3 phosphorylates IWS1, which alters U2AF2 RNA splicing and promotes growth of lung adenocarcinomas via a Sororin/ERK
Externí odkaz:
https://doaj.org/article/d561adaf19ee4c4ab175614033a5dedb
Autor:
Alessandro La Ferlita, Salvatore Alaimo, Sebastiano Di Bella, Emanuele Martorana, Georgios I. Laliotis, Francesco Bertoni, Luciano Cascione, Philip N. Tsichlis, Alfredo Ferro, Roberta Bosotti, Alfredo Pulvirenti
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-16 (2021)
Abstract Background RNA-Seq is a well-established technology extensively used for transcriptome profiling, allowing the analysis of coding and non-coding RNA molecules. However, this technology produces a vast amount of data requiring sophisticated c
Externí odkaz:
https://doaj.org/article/4e360b93746c4bf4a5e05628bf5e1e7a
Autor:
Salvatore Alaimo, Rosaria Valentina Rapicavoli, Gioacchino P Marceca, Alessandro La Ferlita, Oksana B Serebrennikova, Philip N Tsichlis, Bud Mishra, Alfredo Pulvirenti, Alfredo Ferro
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 6, p e1009069 (2021)
Despite the unprecedented growth in our understanding of cell biology, it still remains challenging to connect it to experimental data obtained with cells and tissues' physiopathological status under precise circumstances. This knowledge gap often re
Externí odkaz:
https://doaj.org/article/afc4a2233c524ecf9bcb92d8fc065807
Autor:
Georgios I. Laliotis, Evangelia Chavdoula, Maria D. Paraskevopoulou, Abdul Kaba, Alessandro La Ferlita, Satishkumar Singh, Vollter Anastas, Keith A. Nair, Arturo Orlacchio, Vasiliki Taraslia, Ioannis Vlachos, Marina Capece, Artemis Hatzigeorgiou, Dario Palmieri, Christos Tsatsanis, Salvatore Alaimo, Lalit Sehgal, David P. Carbone, Vincenzo Coppola, Philip N. Tsichlis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/5b5c850325bc4e3a8c96cdcd15103370
Autor:
Nefeli Zacharopoulou, Anna Tsapara, Galatea Kallergi, Evi Schmid, Saad Alkahtani, Saud Alarifi, Philip N. Tsichlis, Sotirios C. Kampranis, Christos Stournaras
Publikováno v:
Cellular Physiology and Biochemistry, Vol 47, Iss 1, Pp 368-377 (2018)
Background/Aims: The epigenetic factor KDM2B is a histone demethylase expressed in various tumors. Recently, we have shown that KDM2B regulates actin cytoskeleton organization, small Rho GTPases signaling, cell-cell adhesion and migration of prostate
Externí odkaz:
https://doaj.org/article/8cef26e9a45c4b9086ba25ab811caabd
Publikováno v:
Seminars in Cancer Biology. 86:543-554
Small cell lung cancer (SCLC) is an extremely aggressive neuroendocrine tumor, accounting for approximated 13% of all lung cancer cases. SCLC is characterized by rapid growth and early metastasis. Despite marked improvements in the number and efficac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34dc32783b77aba3a9c0520ad7ce649b
https://doi.org/10.1016/j.semcancer.2022.04.001
https://doi.org/10.1016/j.semcancer.2022.04.001