Zobrazeno 1 - 10
of 495
pro vyhledávání: '"Philip N, Ainslie"'
Autor:
Jules M. Janssen Daalen, Marjan J. Meinders, Soania Mathur, Hieronymus W.H. van Hees, Philip N. Ainslie, Dick H.J. Thijssen, Bastiaan R. Bloem
Publikováno v:
BMC Neurology, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background Parkinson’s disease (PD) is a neurodegenerative disease for which no disease-modifying therapies exist. Preclinical and clinical evidence suggest that repeated exposure to intermittent hypoxia might have short- and long-term ben
Externí odkaz:
https://doaj.org/article/cada589cfb2e4325bb0fca7a3a9b7b05
Autor:
Jack S. Talbot, Dean R. Perkins, Christine M. Tallon, Tony G. Dawkins, Andrew J. M. Douglas, Ryan Beckerleg, Andrew Crofts, Melissa E. Wright, Saajan Davies, Jessica J. Steventon, Kevin Murphy, Rachel N. Lord, Christopher J. A. Pugh, Jon L. Oliver, Rhodri S. Lloyd, Philip N. Ainslie, Ali M. McManus, Mike Stembridge
Publikováno v:
Experimental Physiology, Vol 108, Iss 12, Pp 1500-1515 (2023)
Abstract Global cerebral blood flow (gCBF) and cerebrovascular reactivity to hypercapnia (CVRCO2) are modulated by gonadal hormone activity, while insulin‐like growth factor 1 facilitates exercise‐mediated cerebral angiogenesis in adults. Whether
Externí odkaz:
https://doaj.org/article/20b61a3e79984408bcdf31f2b7030741
Autor:
Jules M. Janssen Daalen, Marjan J. Meinders, Isabel R. Straatsma, Philip N. Ainslie, Dick H. J. Thijssen, Bastiaan R. Bloem
Publikováno v:
BMC Neurology, Vol 23, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/e70ab36a903e4246b63ec383cc38324d
Autor:
Prajan Subedi, Christopher Gasho, Michael Stembridge, Alexandra M. Williams, Alexander Patrician, Philip N. Ainslie, James D. Anholm
Publikováno v:
Experimental Physiology, Vol 108, Iss 1, Pp 111-122 (2023)
Abstract Prolonged alveolar hypoxia leads to pulmonary vascular remodelling. We examined the time course at altitude, over which hypoxic pulmonary vasoconstriction goes from being acutely reversible to potentially irreversible. Study subjects were lo
Externí odkaz:
https://doaj.org/article/14c45d9702594740a9d007e981f1c48d
Autor:
Jules M. Janssen Daalen, Marjan J. Meinders, Federica Giardina, Kit C. B. Roes, Bas C. Stunnenberg, Soania Mathur, Philip N. Ainslie, Dick H. J. Thijssen, Bastiaan R. Bloem
Publikováno v:
BMC Neurology, Vol 22, Iss 1, Pp 1-12 (2022)
Abstract Background Parkinson’s disease (PD) is a neurodegenerative disease, for which no disease-modifying therapies exist. Preclinical and clinical evidence suggest that hypoxia-based therapy might have short- and long-term benefits in PD. We pre
Externí odkaz:
https://doaj.org/article/e444660f0b144644abab9ac05a31d6ee
Autor:
Rebecca Rimbach, Yosuke Yamada, Hiroyuki Sagayama, Philip N. Ainslie, Lene F. Anderson, Liam J. Anderson, Lenore Arab, Issaad Baddou, Kweku Bedu-Addo, Ellen E. Blaak, Stephane Blanc, Alberto G. Bonomi, Carlijn V. C. Bouten, Pascal Bovet, Maciej S. Buchowski, Nancy F. Butte, Stefan G. J. A. Camps, Graeme L. Close, Jamie A. Cooper, Sai Krupa Das, Lara R. Dugas, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W. Fudge, Annelies H. Goris, Michael Gurven, Catherine Hambly, Asmaa El Hamdouchi, Marije B. Hoos, Sumei Hu, Noorjehan Joonas, Annemiek M. Joosen, Peter Katzmarzyk, Kitty P. Kempen, Misaka Kimura, William E. Kraus, Robert F. Kushner, Estelle V. Lambert, William R. Leonard, Nader Lessan, Corby K. Martin, Anine C. Medin, Erwin P. Meijer, James C. Morehen, James P. Morton, Marian L. Neuhouser, Theresa A. Nicklas, Robert M. Ojiambo, Kirsi H. Pietiläinen, Yannis P. Pitsiladis, Jacob Plange-Rhule, Guy Plasqui, Ross L. Prentice, Roberto A. Rabinovich, Susan B. Racette, David A. Raichlen, Eric Ravussin, Rebecca M. Reynolds, Susan B. Roberts, Albertine J. Schuit, Anders M. Sjödin, Eric Stice, Samuel S. Urlacher, Giulio Valenti, Ludo M. Van Etten, Edgar A. Van Mil, Jonathan C. K. Wells, George Wilson, Brian M. Wood, Jack Yanovski, Tsukasa Yoshida, Xueying Zhang, Alexia J. Murphy-Alford, Cornelia U. Loechl, Amy H. Luke, Jennifer Rood, Dale A. Schoeller, Klaas R. Westerterp, William W. Wong, John R. Speakman, Herman Pontzer, The IAEA DLW Database Consortium
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-8 (2022)
Low total energy expenditure (TEE) has been a hypothesized risk factor for weight gain, but longitudinal repeatability of TEE is incompletely understood. Here the authors report that TEE is repeatable for adults, but not for children, and increases i
Externí odkaz:
https://doaj.org/article/aeeff35f0ad4441a88ee798d3e7971d1
Autor:
Xueying Zhang, Yosuke Yamada, Hiroyuki Sagayama, Philip N. Ainslie, Ellen E. Blaak, Maciej S. Buchowski, Graeme L. Close, Jamie A. Cooper, Sai Krupa Das, Lara R. Dugas, Michael Gurven, Asmaa El Hamdouchi, Sumei Hu, Noorjehan Joonas, Peter Katzmarzyk, William E. Kraus, Robert F. Kushner, William R. Leonard, Corby K. Martin, Erwin P. Meijer, Marian L. Neuhouser, Robert M. Ojiambo, Yannis P. Pitsiladis, Guy Plasqui, Ross L. Prentice, Susan B. Racette, Eric Ravussin, Leanne M. Redman, Rebecca M. Reynolds, Susan B. Roberts, Luis B. Sardinha, Analiza M. Silva, Eric Stice, Samuel S. Urlacher, Edgar A. Van Mil, Brian M. Wood, Alexia J. Murphy-Alford, Cornelia Loechl, Amy H. Luke, Jennifer Rood, Dale A. Schoeller, Klaas R. Westerterp, William W. Wong, Herman Pontzer, John R. Speakman, Lene F. Andersen, Liam J. Anderson, Lenore Arab, Issad Baddou, Bedu Addo, Stephane Blanc, Alberto Bonomi, Carlijn V.C. Bouten, Pascal Bovet, Stefan Branth, Niels C. De Bruin, Nancy F. Butte, Lisa H. Colbert, Stephan G. Camps, Alice E. Dutman, Simon D. Eaton, Ulf Ekelund, Sonja Entringer, Cara Ebbeling, Sölve Elmståhl, Mikael Fogelholm, Terrence Forrester, Barry W. Fudge, Tamara Harris, Rik Heijligenberg, Annelies H. Goris, Catherine Hambly, Marije B. Hoos, Hans U. Jorgensen, Annemiek M. Joosen, Kitty P. Kempen, Misaka Kimura, Watanee Kriengsinyos, Estelle V. Lambert, Christel L. Larsson, Nader Lessan, David S. Ludwig, Margaret McCloskey, Anine C. Medin, Gerwin A. Meijer, Eric Matsiko, Alida Melse-Boonstra, James C. Morehen, James P. Morton, Theresa A. Nicklas, Daphne L. Pannemans, Kirsi H. Pietiläinen, Renaat M. Philippaerts, Roberto A. Rabinovich, John J. Reilly, Elisabet M. Rothenberg, Albertine J. Schuit, Sabine Schulz, Anders M. Sjödin, Amy Subar, Minna Tanskanen, Ricardo Uauy, Giulio Valenti, Ludo M. Van Etten, Rita Van den Berg-Emons, Wim G. Van Gemert, Erica J. Velthuis-te Wierik, Wilhelmine W. Verboeket-van de Venne, Jeanine A. Verbunt, Jonathan C.K. Wells, George Wilson
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104682- (2022)
Summary: Lower ambient temperature (Ta) requires greater energy expenditure to sustain body temperature. However, effects of Ta on human energetics may be buffered by environmental modification and behavioral compensation. We used the IAEA DLW databa
Externí odkaz:
https://doaj.org/article/185d20235c154c7c8514e8e72ad6ab8c
Autor:
Patrice Brassard, Lawrence Labrecque, Jonathan D. Smirl, Michael M. Tymko, Hannah G. Caldwell, Ryan L. Hoiland, Samuel J. E. Lucas, André Y. Denault, Etienne J. Couture, Philip N. Ainslie
Publikováno v:
Physiological Reports, Vol 9, Iss 15, Pp n/a-n/a (2021)
Abstract In 1959, Niels Lassen illustrated the cerebral autoregulation curve in the classic review article entitled Cerebral Blood Flow and Oxygen Consumption in Man. This concept suggested a relatively broad mean arterial pressure range (~60–150 m
Externí odkaz:
https://doaj.org/article/b5bff2ce6f6c46edae53b5c80e2c04e8
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Breath-hold diving involves highly integrative physiology and extreme responses to both exercise and asphyxia during progressive elevations in hydrostatic pressure. With astonishing depth records exceeding 100 m, and up to 214 m on a single breath, t
Externí odkaz:
https://doaj.org/article/c1030261d1fd40d797490f93a4dadbeb
Autor:
Lydia L. Simpson, Alexander B. Hansen, Gilbert Moralez, Sachin B. Amin, Florian Hofstaetter, Christopher Gasho, Mike Stembridge, Tony G. Dawkins, Michael M. Tymko, Philip N. Ainslie, Justin S. Lawley, Christopher M. Hearon
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 324:R457-R469
Sympathetic transduction is reduced following chronic high-altitude (HA) exposure; however, vascular α-adrenergic signaling, the primary mechanism mediating sympathetic vasoconstriction at sea level (SL), has not been examined at HA. In nine male lo