Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Philip Marder"'
Publikováno v:
Antimicrobial Agents and Chemotherapy. 43:830-835
LY303366 is a semisynthetic analog of the antifungal lipopeptide echinocandin B that inhibits (1,3)-β- d -glucan synthase and exhibits efficacy in animal models of human fungal infections. In this study, we utilized flow cytometric analysis of propi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5022c121b8b5b09dc429253dd8cd73a
https://doi.org/10.1128/aac.43.4.830
https://doi.org/10.1128/aac.43.4.830
Autor:
Laurane G. Mendelsohn, Lynn S. Gossett, Sherri L. Andis, Richard M. Schultz, Philip Marder, John L. Tonkinson, Chuan Shih
Publikováno v:
Cancer Chemotherapy and Pharmacology. 39:521-531
Purpose: Cell cycle-related events in CCRF-CEM lymphocytic leukemia cells were examined subsequent to inhibition of thymidylate synthase (TS) or GAR formyltransferase (GARFT) and prior to cell death or stasis. Methods: Cell populations were treated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3086c961b4fb9a9aa54ab5c7b7cb4ac6
https://doi.org/10.1007/s002800050608
https://doi.org/10.1007/s002800050608
2-alkyl-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptyloxy]phenol leukotriene B4 receptor antagonists
Autor:
Michael J. Sofia, David K. Herron, Katrina Ann Nelson, Philip Marder, Theodore Goodson, Jerome H. Fleisch, Larry L. Froelich, Carlos R. Roman, Stephen M. Spaethe
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:1995-2000
A series of 2-n-alkyl-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptyloxy]phenols were prepared and shown to be potent leukotriene B4 (LTB4) receptor antagonists. They bound to the human neutrophil and guinea pig lung LTB4 receptors with high affinity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a1f669ee07c369a26013a3dcb87d5bd
https://doi.org/10.1016/0960-894x(95)00340-y
https://doi.org/10.1016/0960-894x(95)00340-y
Autor:
Virginia Litwin, Philip Marder
This book covers the unique application of flow cytometry in drug discovery and development. The first section includes two introductory chapters, one on flow cytometry and one on biomarkers, as well as a chapter on recent advances in flow cytometry.
Autor:
Elisabeth A. Schmittling, William T. Jackson, J. Scott Sawyer, David L. Saussy, S. Richard Baker, Philip Marder, Bach Nicholas J, Larry L. Froelich
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:2077-2082
We report the preparation and pharmacologic activity of three spatial analogues of LY292728, a highly potent xanthone dicarboxylic LTB4 receptor antagonist. Molecular modeling of these compounds has helped to further elucidate the nature of the secon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a98d4753abc9e9b078133a5a20eee6f5
https://doi.org/10.1016/s0960-894x(01)80105-0
https://doi.org/10.1016/s0960-894x(01)80105-0
Autor:
Larry L. Froelich, Carlos R. Roman, Sandra L. Cockerham, Floreancig Paul Edward, William T. Jackson, Philip Marder, Michael J. Sofia, Peter W. Stengel, Steven A. Silbaugh, Jerome H. Fleisch, David L. Saussy
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:1147-1152
7-[4-Acetyl-2-ethyl-5-hydroxyphenoxy)propoxy]-3,4-dihydro-8-propyl-2H-1-benzopyran-2-carboxylic acid sodium salt 7 (LY247826) and several 7-[3-(4-acetyl-2-ethyl-5-hydroxyphenoxy)propoxy)-2-propylphenoxy] acetic acid analogues were prepared as LTB4 re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06bce8a25799f50a6136a6998c69220c
https://doi.org/10.1016/s0960-894x(00)80304-2
https://doi.org/10.1016/s0960-894x(00)80304-2
Autor:
Virginia Litwin, Philip Marder
Publikováno v:
Flow Cytometry in Drug Discovery and Development: Litwin/Flow Cytometry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ede0f52fa4b863358d1462859470892
https://doi.org/10.1002/9780470910085
https://doi.org/10.1002/9780470910085
Autor:
Sandra L. Cockerham, Peter W. Stengel, William T. Jackson, Philip Marder, Steven A. Silbaugh, Michael J. Sofia, Larry L. Froelich, David L. Saussy
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:1675-1680
Several ortho -alkoxyphenols containing a chroman carboxylic acid sidechain have been prepared as antagonists of leukotriene B4 receptors. These antagonists were compared to their parent alkoxyphenols containing the tetrazole acid sidechain. These ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c005da68c5cf88aa60711a5d5e1689d4
https://doi.org/10.1016/s0960-894x(00)80454-0
https://doi.org/10.1016/s0960-894x(00)80454-0
Publikováno v:
Molecular cancer therapeutics. 6(9)
Thrombin cleavages of selective proteinase-activated receptors (PAR) as well as PAR-activating peptide ligands can initiate the phosphoinositide 3-kinase (PI3K) signaling cascade in platelets. Downstream to this event, fibrinogen receptors on platele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::115f61ab7bd84edc26a4cfb8b1aedfef
https://pubmed.ncbi.nlm.nih.gov/17766838
https://pubmed.ncbi.nlm.nih.gov/17766838