Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Philip Mallinder"'
Autor:
Ross Stewart, Robert W. Wilkinson, Ching Ching Leow, Athula Herath, Philip Mallinder, Scott A. Hammond, Michelle Morrow, Lesley Young, Kelly McGlinchey, David A. Leinster, Jane Coates Ulrichsen, Michael D. Oberst, Stefanie Mullins, Li Yan, John Andrews, Emily Offer, Natalie J. Tigue, Lisa Bamber, Nicholas Holoweckyj, Kathy A. Mulgrew, Amanda Watkins, Rebecca Leyland
Additional materials and methods and supplementary figure legends with tracked changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::671e099e5f25fb580caea686b8b7f676
https://doi.org/10.1158/1078-0432.22463777.v1
https://doi.org/10.1158/1078-0432.22463777.v1
Autor:
Ross Stewart, Robert W. Wilkinson, Ching Ching Leow, Athula Herath, Philip Mallinder, Scott A. Hammond, Michelle Morrow, Lesley Young, Kelly McGlinchey, David A. Leinster, Jane Coates Ulrichsen, Michael D. Oberst, Stefanie Mullins, Li Yan, John Andrews, Emily Offer, Natalie J. Tigue, Lisa Bamber, Nicholas Holoweckyj, Kathy A. Mulgrew, Amanda Watkins, Rebecca Leyland
Supplementary figures S1-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697d83739c7675c2a3405246bc4a4539
https://doi.org/10.1158/1078-0432.22463783.v1
https://doi.org/10.1158/1078-0432.22463783.v1
Autor:
Ross Stewart, Robert W. Wilkinson, Ching Ching Leow, Athula Herath, Philip Mallinder, Scott A. Hammond, Michelle Morrow, Lesley Young, Kelly McGlinchey, David A. Leinster, Jane Coates Ulrichsen, Michael D. Oberst, Stefanie Mullins, Li Yan, John Andrews, Emily Offer, Natalie J. Tigue, Lisa Bamber, Nicholas Holoweckyj, Kathy A. Mulgrew, Amanda Watkins, Rebecca Leyland
Purpose: To generate and characterize a murine GITR ligand fusion protein (mGITRL-FP) designed to maximize valency and the potential to agonize the GITR receptor for cancer immunotherapy.Experimental Design: The EC50 value of the mGITRL-FP was compar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a7e495d8f0b024911cdaaba2097a9fc
https://doi.org/10.1158/1078-0432.c.6525515
https://doi.org/10.1158/1078-0432.c.6525515
Autor:
Ross Stewart, Robert W. Wilkinson, Ching Ching Leow, Athula Herath, Philip Mallinder, Scott A. Hammond, Michelle Morrow, Lesley Young, Kelly McGlinchey, David A. Leinster, Jane Coates Ulrichsen, Michael D. Oberst, Stefanie Mullins, Li Yan, John Andrews, Emily Offer, Natalie J. Tigue, Lisa Bamber, Nicholas Holoweckyj, Kathy A. Mulgrew, Amanda Watkins, Rebecca Leyland
Additional materials and methods and supplementary figure legends.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d03ee0abf1e2c2c527f5f5b6e61da07
https://doi.org/10.1158/1078-0432.22463780.v1
https://doi.org/10.1158/1078-0432.22463780.v1
Autor:
Michael S. Gordon, Naiyer A. Rizvi, Ignacio González-García, Philip Mallinder, Jennifer Cann, Ashish V. Chintakuntlawar, Raid Aljumaily, Helen J. Ross, Shahram Rahimian, Nairouz Elgeioushi, Nathan Standifer, Aung Naing, Crystal S. Denlinger, Nicholas M. Durham, Rakesh Kumar, Ani Sarkis Balmanoukian, Jeffrey R. Infante
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 26(23)
Purpose: The safety and preliminary efficacy of MEDI1873, an agonistic IgG1 fusion protein targeting glucocorticoid-induced TNF receptor–related protein (GITR), were evaluated in an open-label, first-in-human, phase I, dose escalation study in prev
Autor:
Elaine Cadogan, Andrew Churg, Don D. Sin, Katherine R. Thain, Justine Maltby, S J Bolton, Philip Mallinder, Caroline Marshall, Joanne L. Wright, Matthew G. Soars, Steven Zhou
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 185:34-43
Inflammation and oxidative stress are linked to the deleterious effects of cigarette smoke in producing chronic obstructive pulmonary disease (COPD). Myeloperoxidase (MPO), a neutrophil and macrophage product, is important in bacterial killing, but a
Autor:
Michael Fung, Duncan James Cochrane, Raffaella Faggioni, Franco Ferraro, Sara Botterell, Simon Charles Cruwys, Matthew A. Sleeman, Jamie Iain Campbell, Roland Kolbeck, Meina Liang, Elizabeth Rendall, Tristan J. Vaughan, Steven Lane, Gareth Rees, David C. Lowe, Monisha Sinha, Amy Schneider, Jacques Moisan, Trevor Wilkinson, Donna K. Finch, Craig Walker, Elizabeth England, Michael A. Bowen, Philip Mallinder
Publikováno v:
Journal of Molecular Biology. 411:791-807
The differentiation of therapeutic monoclonal antibodies in an increasingly competitive landscape requires optimization of clinical efficacy combined with increased patient convenience. We describe here the generation of MEDI5117, a human anti-interl
Autor:
Stephen Connolly, Antonio Mete, Glen Andrews, Nigel Gensmantel, Gunilla Andersson, Matt D. Kroeger, Andrew S. Arvai, Peter Hamley, Stephen A. St-Gallay, Brian R. Crane, Elizabeth D. Getzoff, Alan V. Wallace, Anders Åberg, Robin J. Rosenfeld, Philip Mallinder, David J. Nicholls, John A. Tainer, Dennis J. Stuehr, Elsa D. Garcin, Tinker Alan, David Cheshire
Publikováno v:
Nature chemical biology
Nitric oxide synthase (NOS) enzymes synthesize nitric oxide, a signal for vasodilatation and neurotransmission at low concentrations and a defensive cytotoxin at higher concentrations. The high active site conservation among all three NOS isozymes hi
Autor:
Alasdair Gaw, Lorna Bowers, Tomkinson Nicholas, Katherine Elisabeth Wiley, Caroline Grahames, Philip Shelton, Tracey J. Wright, Anne Brammall, David J. Nicholls, Premji Meghani, Philip Mallinder
Publikováno v:
Molecular Pharmacology. 74:1193-1202
The chemokine receptors CXCR1 and CXCR2 are G-protein-coupled receptors (GPCRs) implicated in mediating cellular functions associated with the inflammatory response. Potent CXCR2 receptor antagonists have been discovered, some of which have recently
Autor:
Alison Ward, Stefan Gerhardt, Richard A. Pauptit, Matthew A. Sleeman, Philip Mallinder, Bojana Popovic, Tristan J. Vaughan, Catriona L Buchanan, David C. Lowe, Trevor Wilkinson, Franco Ferraro, Debbie V. Pattison, Donna K. Finch, David J. Hargreaves, Malcolm Anderson
Publikováno v:
Journal of molecular biology. 406(1)
Interleukin (IL) 15 is an inflammatory cytokine that plays an essential role in the activation, proliferation, and maintenance of specific natural killer cell and T-cell populations, and has been implicated as a mediator of inflammatory diseases. An