Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Philip Maini"'
Standard-of-care treatment regimes have long been designed to for maximal cell kill, yet these strategies often fail when applied to treatment–resistant tumors, resulting in patient relapse. Adaptive treatment strategies have been developed as an a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::360a2d0f07d87cbf543a6464f885927a
https://doi.org/10.1101/2023.04.28.538766
https://doi.org/10.1101/2023.04.28.538766
Autor:
Maximilian Strobl, Alexandra L. Martin, Jeffrey West, Jill Gallaher, Mark Robertson-Tessi, Robert Gatenby, Robert Wenham, Philip Maini, Mehdi Damaghi, Alexander Anderson
Publikováno v:
bioRxiv
Toxicity and emerging drug resistance are important challenges in PARP inhibitor (PARPi) treatment of ovarian cancer. Recent research has shown that evolutionary-inspired treatment algorithms which adapt treatment to the tumor’s treatment response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6d68267af23860d6915841b0caa12f1
https://europepmc.org/articles/PMC10055330/
https://europepmc.org/articles/PMC10055330/
Autor:
Maximilian Strobl, Mehdi Damaghi, Alexandra Martin, Samantha Byrne, Mark Robertson-Tessi, Robert Gatenby, Robert Wenham, Philip Maini, Alexander R.A. Anderson
Publikováno v:
Cancer Research. 82:B009-B009
PARP inhibitors (PARPis) represent a great advancement in the treatment of ovarian cancer, yet these drugs often fail after a few months due to emerging drug resistance. A recent clinical trial in prostate cancer showed that evolutionary-inspired, ad
Autor:
Khaphetsi Joseph, Mahasa, Lisette, de Pillis, Rachid, Ouifki, Amina, Eladdadi, Philip, Maini, A-Rum, Yoon, Chae-Ok, Yun
Publikováno v:
Scientific Reports
Mesenchymal stem cells (MSCs) loaded with oncolytic viruses are presently being investigated as a new modality of advanced/metastatic tumors treatment and enhancement of virotherapy. MSCs can, however, either promote or suppress tumor growth. To addr
Today, biologists and mathematicians work together not only to find structure in the vast quantities of data flowing from experiment but also to integrate this information into models that explain at multiple scales of time and space how life works.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f97ef8844fa7ec345505b61cd076f51
https://ora.ox.ac.uk/objects/uuid:74537c53-6959-4033-bfae-8fe5569f4b1e
https://ora.ox.ac.uk/objects/uuid:74537c53-6959-4033-bfae-8fe5569f4b1e
A central goal of current biology is to decode the mechanisms that underlie the processes of morphogenesis and pattern formation. Concerned with the analysis of those phenomena, this book covers a broad range of research fields, including development
Centrosomin (Cnn) is an integral centrosomal protein in Drosophila with orthologues in several species, including humans. The human orthologue of Cnn is required for brain development with Cnn hypothesised to play a similar role in Drosophila. Contro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1064::585709fa6a91810465f0b71d5e2a656c
http://ora.ox.ac.uk/objects/uuid:baefde65-bc38-4a11-bd92-e2e4cccad784
http://ora.ox.ac.uk/objects/uuid:baefde65-bc38-4a11-bd92-e2e4cccad784
Colorectal cancer has the third highest mortality and incidence rates of all cancers worldwide, but the prognosis for long-term survival is good if diagnosed early. It is a well-characterised disease, and is initiated in colonic crypts which line the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1064::ef6bf43a9c3f103a5dd80a98eab9f81c
http://ora.ox.ac.uk/objects/uuid:eb1daf53-203c-4ed5-a8af-ab261a61a88c
http://ora.ox.ac.uk/objects/uuid:eb1daf53-203c-4ed5-a8af-ab261a61a88c
Publikováno v:
The Journal of Immunology. 194:58.10-58.10
T cell activation is a crucial checkpoint in adaptive immunity, and this activation depends on the binding parameters between the T cell receptor (TCR) and peptide-MHC (pMHC) complexes as well as the dose at which the pMHC is presented. Despite exten