Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Philip M. Sher"'
Autor:
Sara Shama, Michelle R. Asbury, Alex Kiss, Nicole Bando, James Butcher, Elena M. Comelli, Julia K. Copeland, Adrianna Greco, Akash Kothari, Philip M. Sherman, Alain Stintzi, Amel Taibi, Christopher Tomlinson, Sharon Unger, Pauline W. Wang, Deborah L. O’Connor
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101729- (2024)
Summary: Mother’s milk contains diverse bacterial communities, although their impact on microbial colonization in very-low-birth-weight (VLBW,
Externí odkaz:
https://doaj.org/article/56ecea613ce64d9f9a7e0807b9cfa06c
Autor:
Mary Jane Cullen, Qian Xiang, Jeffrey A. Robl, Philip M. Sher, Brian J. Murphy, Keith J. Miller, Timothy M. Harper, Andrew Alt, Emily Luk, Sarah E. Malmstrom, Dean A. Wacker, Ginger Wu, Kimberly A. Foster, John M. Fevig, Joseph Carpenter, Robert L. Bertekap, Mary F. Grubb, Ying Wang, Karen A. Rossi, Gang Wu, Christian L. Morales, Jianxin Feng, Xiang Yang Ye, Anthony V. Azzara, Matthias Broekema
Publikováno v:
Journal of Medicinal Chemistry. 60:6166-6190
Agonism of the 5-HT2C receptor represents one of the most well-studied and clinically proven mechanisms for pharmacological weight reduction. Selectivity over the closely related 5-HT2A and 5-HT2B receptors is critical as their activation has been sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ab408370d6568ec38a8faeab8daced5
https://doi.org/10.1021/acs.jmedchem.7b00385
https://doi.org/10.1021/acs.jmedchem.7b00385
Autor:
Jakaria Shawon, Lisa G. Pell, Mamun Kabir, Kara Evans, Mehedi Hasan, Grace Li, Huma Qamar, Cody W. E. Starke, Shakya Kurukulasuriya, Abdullah Al Mahmud, Philip M. Sherman, Shafiqul Alam Sarker, Daniel E. Roth, Rashidul Haque
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 1 (2024)
ABSTRACT Lactiplantibacillus plantarum ATCC 202195 has probiotic properties that may be beneficial in early infancy. Since the effects of probiotics are often strain and dose specific, tools are needed to identify and enumerate L. plantarum ATCC 2021
Externí odkaz:
https://doaj.org/article/252a1a84f1c04706bfcba025024c5f3c
Autor:
Joseph, Carpenter, Ying, Wang, Gang, Wu, Jianxin, Feng, Xiang-Yang, Ye, Christian L, Morales, Matthias, Broekema, Karen A, Rossi, Keith J, Miller, Brian J, Murphy, Ginger, Wu, Sarah E, Malmstrom, Anthony V, Azzara, Philip M, Sher, John M, Fevig, Andrew, Alt, Robert L, Bertekap, Mary Jane, Cullen, Timothy M, Harper, Kimberly, Foster, Emily, Luk, Qian, Xiang, Mary F, Grubb, Jeffrey A, Robl, Dean A, Wacker
Publikováno v:
Journal of medicinal chemistry. 60(14)
Agonism of the 5-HT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b4aad16c8dfe5c23e1f667fa571a60d5
https://pubmed.ncbi.nlm.nih.gov/28635286
https://pubmed.ncbi.nlm.nih.gov/28635286
Autor:
Kenneth E. Carlson, Olafur S. Gudmundsson, Bruce A. Ellsworth, Philip M. Sher, Susan Harvey, Eva Zuvich, Michael Thomas, William J. Keim, Gang Wu, Helen E. Godonis, Paul Stetsko, Brian J. Murphy, Richard B. Sulsky, Guixue Yu, William R. Ewing, Mary Jane Cullen, Mary Ann Pelleymounter, Doree F. Sitkoff, Susan Johnghar, Zhengxiang Gu, Ximao Wu, James Devenny, Rose Ann F Baska, Asoka Ranasinghe, Ning Lee, Kamelia Behnia, Anthony V. Azzara, Kenneth W. Rohrbach, Gerry Everlof, Liya Kang, Natesan Murugesan, Yeheng Zhu, Yifan Yang
Publikováno v:
Journal of Medicinal Chemistry. 56:9586-9600
Several strategies have been employed to reduce the long in vivo half-life of our lead CB1 antagonist, triazolopyridazinone 3, to differentiate the pharmacokinetic profile versus the lead clinical compounds. An in vitro and in vivo clearance data set
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::417c836ddf3010c89cd9792afb3349b0
https://doi.org/10.1021/jm4010835
https://doi.org/10.1021/jm4010835
Autor:
Philip M. Sher, Wei Meng, William N. Washburn, Nathan Morgan, Deborah Hagan, Mary T. Obermeier, Ravindar N. Girotra, Gang Wu, Jean M. Whaley, Manorama Patel, Thomas L. Waldron, Bruce A. Ellsworth, James G. Robertson, Aiying Wang, Songping Han, William G. Humphreys
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4770-4773
Inhibition of sodium-dependent glucose transporter 2 (SGLT2), the transporter that is responsible for renal re-uptake of glucose, leads to glucosuria in animals. SGLT-mediated glucosuria provides a mechanism to shed excess plasma glucose to ameliorat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55f1b4eba914f6b7a06486c60d355c16
https://doi.org/10.1016/j.bmcl.2008.07.109
https://doi.org/10.1016/j.bmcl.2008.07.109
Autor:
A A Seymour, William N. Washburn, Dorothy Slusarchyk, P.J. McCann, B.E. Abboa-Offei, Minsheng Zhang, G.T. Allen, Ravindar N. Girotra, B.H. Frohlich, Michael Cap, Jollie D. Godfrey, Peter T. W. Cheng, R.J. George, C. Shao, Anita D. Russell, S. Skwish, Philip M. Sher, Jon J. Hangeland, A.V. Gavai, T.L. Waldron, Belay Tesfamariam, Yolanda Caringal, T.W. Harper, Tamara Dejneka, Kenneth E.J. Dickinson, Ginger Wu, Syed Z. Ahmed, Amarendra B. Mikkilineni, Hongwei Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4290-4296
Utilization of N-substituted-4-hydroxy-3-methylsulfonanilidoethanolamines 1 as selective beta(3) agonists is complicated by their propensity to undergo metabolic oxidative N-dealkylation, generating 0.01-2% of a very potent alpha(1) adrenergic agonis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db28be835bfadb1da0ebd09bad48db49
https://doi.org/10.1016/j.bmcl.2007.05.030
https://doi.org/10.1016/j.bmcl.2007.05.030
Autor:
Zhen-Wei Cai, Philip M. Sher, Ashvinikumar V. Gavai, O. Kocy, and Michael A. Poss, Mark S. Bednarz, William N. Washburn, Gang Wu, Jollie D. Godfrey
Publikováno v:
Journal of Combinatorial Chemistry. 7:99-108
Benzylic and allylic organozinc and Grignard reagents have been added to resin-bound imines to provide alpha-branched secondary amines. Many functional groups, including electrophilic groups, were compatible with this methodology. Three modules--a re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::826b854036730ee7da0c3d6f13ca040a
https://doi.org/10.1021/cc0498682
https://doi.org/10.1021/cc0498682
Autor:
Liesl G. Fisher, P.J. McCann, D.A. Young, C.M. Arbeeny, S. Skwish, Amarendra B. Mikkilineni, Poss Kathleen M, G.T. Allen, Chongqing Sun, Michael Cap, R.J. George, Dorothy Slusarchyk, B.E. Abboa-Offei, Ravindar N. Girotra, William N. Washburn, Carl P. Ciosek, A.V. Gavai, Belay Tesfamariam, T.W. Harper, Ginger Wu, B.H. Frohlich, D.E. Hillyer, Tammy C. Wang, A A Seymour, Mark S. Bednarz, Philip M. Sher, Kenneth E.J. Dickinson, T.L. Waldron, Arvind Mathur
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:3041-3044
A series of 4-hydroxy-3-methylsulfonanilido-1,2-diarylethylamines were prepared and evaluated for their human beta(3) adrenergic receptor agonist activity. SAR studies led to the identification of BMS-196085 (25), a potent beta(3) full agonist (K(i)=
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa60fae9d49d33984476839ff530ef2
https://doi.org/10.1016/s0960-894x(01)00629-1
https://doi.org/10.1016/s0960-894x(01)00629-1
Autor:
Philip M. Sher, Liesl G. Fisher, Steven M. Seiler, Inge M. Michel, S. Skwish, Gang Wu, Arvind Mathur, Kenneth E.J. Dickinson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:1583-1588
Carboxyl and other negatively charged groups were found to be most effective at producing human β3 adrenergic receptor binding selectivity in 1 (BRL 37344) and related compounds. The sulfonic acid analog 7 (BMS-187413) is a novel and potent β3 adre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b95216739317574ff137c279e3fb5fec
https://doi.org/10.1016/s0960-894x(97)00266-7
https://doi.org/10.1016/s0960-894x(97)00266-7