Zobrazeno 1 - 10
of 321
pro vyhledávání: '"Philip M. Murphy"'
Autor:
Adrienne Anginot, Julie Nguyen, Zeina Abou Nader, Vincent Rondeau, Amélie Bonaud, Maria Kalogeraki, Antoine Boutin, Julia P. Lemos, Valeria Bisio, Joyce Koenen, Lea Hanna Doumit Sakr, Amandine Picart, Amélie Coudert, Sylvain Provot, Nicolas Dulphy, Michel Aurrand-Lions, Stéphane J. C. Mancini, Gwendal Lazennec, David H. McDermott, Fabien Guidez, Claudine Blin-Wakkach, Philip M. Murphy, Martine Cohen-Solal, Marion Espéli, Matthieu Rouleau, Karl Balabanian
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract WHIM Syndrome is a rare immunodeficiency caused by gain-of-function CXCR4 mutations. Here we report a decrease in bone mineral density in 25% of WHIM patients and bone defects leading to osteoporosis in a WHIM mouse model. Imbalanced bone ti
Externí odkaz:
https://doaj.org/article/71e743108c284ff4a7d508b10f487735
Autor:
David H. McDermott, Daniel Velez, Elena Cho, Edward W. Cowen, John J. DiGiovanna, Diana V. Pastrana, Christopher B. Buck, Katherine R. Calvo, Pamela J. Gardner, Sergio D. Rosenzweig, Pamela Stratton, Melissa A. Merideth, H. Jeffrey Kim, Carmen Brewer, James D. Katz, Douglas B. Kuhns, Harry L. Malech, Dean Follmann, Michael P. Fay, Philip M. Murphy
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 19 (2023)
BACKGROUND Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome is a primary immunodeficiency disorder caused by heterozygous gain-of-function CXCR4 mutations. Myelokathexis is a kind of neutropenia caused by neutrophil retenti
Externí odkaz:
https://doaj.org/article/98358f563c30456d8a0d14cbd0e6b4b5
Autor:
Sergio M. Pontejo, Philip M. Murphy
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/b2752b0426ec47cca002bf7eb34246ef
Autor:
Yuta Yamamura, Kengo Furuichi, Yasuhiro Murakawa, Shigeki Hirabayashi, Masahito Yoshihara, Keisuke Sako, Shinji Kitajima, Tadashi Toyama, Yasunori Iwata, Norihiko Sakai, Kazuyoshi Hosomichi, Philip M. Murphy, Atsushi Tajima, Keisuke Okita, Kenji Osafune, Shuichi Kaneko, Takashi Wada
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract PAX2 is a transcription factor essential for kidney development and the main causative gene for renal coloboma syndrome (RCS). The mechanisms of PAX2 action during kidney development have been evaluated in mice but not in humans. This is a c
Externí odkaz:
https://doaj.org/article/441f6fd5b00847cfaaed60ac37342f8f
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
Transplantation of allogeneic bone marrow helps establish chimerism that may induce tolerance to tissue grafts. Here the authors show that a CD117-antibody-drug-conjugate helps precondition the recipients for inducing mixed chimerism and allo-toleran
Externí odkaz:
https://doaj.org/article/2dddc27bdce0404992038db99358a2da
Autor:
Shamik Majumdar, Philip M. Murphy
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
SARS-CoV-2 (Severe Acute Respiratory Syndrome coronavirus-2) is the third coronavirus to emerge as a cause of severe and frequently fatal pneumonia epidemics in humans, joining SARS-CoV and MERS-CoV (Middle East Respiratory Syndrome-coronavirus). As
Externí odkaz:
https://doaj.org/article/2558c77cb7ca4197bda95c8e9eae441d
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/01f4a225819a4c15985b3167d72ded3c
Autor:
David H. McDermott, Lauren E. Heusinkveld, Wadih M. Zein, H. Nida Sen, Martha M. Marquesen, Mark Parta, Sergio D. Rosenzweig, Gary A. Fahle, Michael D. Keller, Henry E. Wiley, Philip M. Murphy
Publikováno v:
F1000Research, Vol 8 (2019)
A patient with WHIM syndrome immunodeficiency presented with sudden painless right eye blindness associated with advanced retinal and optic nerve damage. Toxoplasma gondii was detected by PCR in vitreous fluid but not serum. The patient was treated w
Externí odkaz:
https://doaj.org/article/dcbc679e4ede4d2fae6f91f8f6d502d2
Autor:
David H. McDermott, Lauren E. Heusinkveld, Wadih M. Zein, H. Nida Sen, Martha M. Marquesen, Mark Parta, Sergio D. Rosenzweig, Gary A. Fahle, Michael D. Keller, Henry E. Wiley, Philip M. Murphy
Publikováno v:
F1000Research, Vol 8 (2019)
A patient with WHIM syndrome immunodeficiency presented with sudden painless right eye blindness associated with advanced retinal and optic nerve damage. Toxoplasma gondii was detected by PCR in vitreous fluid but not serum. The patient was treated w
Externí odkaz:
https://doaj.org/article/64e10cff075145eda6f00ed6633defbd
Autor:
Philip M. Murphy, Michael J. Lenardo
Publikováno v:
Biomedicines, Vol 9, Iss 3, p 244 (2021)
Ulrich Siebenlist, Ph [...]
Externí odkaz:
https://doaj.org/article/7bcd51341f6546b3bf77213b96135276