Zobrazeno 1 - 10
of 579
pro vyhledávání: '"Philip M. Hansbro"'
Autor:
Jay C. Horvat, Richard Y. Kim, Natasha Weaver, Christopher Augood, Alexandra C. Brown, Chantal Donovan, Pierrick Dupre, Lakshitha Gunawardhana, Jemma R. Mayall, Nicole G. Hansbro, Avril A. B. Robertson, Luke A. J. O’Neill, Matthew A. Cooper, Elizabeth G. Holliday, Philip M. Hansbro, Peter G. Gibson
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-14 (2023)
Abstract Background Increased airway NLRP3 inflammasome-mediated IL-1β responses may underpin severe neutrophilic asthma. However, whether increased inflammasome activation is unique to severe asthma, is a common feature of immune cells in all infla
Externí odkaz:
https://doaj.org/article/60288ffe24fd40148d0b5a1960f9d444
Autor:
Gang Liu, Tatt Jhong Haw, Malcolm R. Starkey, Ashleigh M. Philp, Stelios Pavlidis, Christina Nalkurthi, Prema M. Nair, Henry M. Gomez, Irwan Hanish, Alan CY. Hsu, Elinor Hortle, Sophie Pickles, Joselyn Rojas-Quintero, Raul San Jose Estepar, Jacqueline E. Marshall, Richard Y. Kim, Adam M. Collison, Joerg Mattes, Sobia Idrees, Alen Faiz, Nicole G. Hansbro, Ryutaro Fukui, Yusuke Murakami, Hong Sheng Cheng, Nguan Soon Tan, Sanjay H. Chotirmall, Jay C. Horvat, Paul S. Foster, Brian GG. Oliver, Francesca Polverino, Antonio Ieni, Francesco Monaco, Gaetano Caramori, Sukhwinder S. Sohal, Ken R. Bracke, Peter A. Wark, Ian M. Adcock, Kensuke Miyake, Don D. Sin, Philip M. Hansbro
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-24 (2023)
Abstract Toll-like receptor 7 (TLR7) is known for eliciting immunity against single-stranded RNA viruses, and is increased in both human and cigarette smoke (CS)-induced, experimental chronic obstructive pulmonary disease (COPD). Here we show that th
Externí odkaz:
https://doaj.org/article/c49c73a4f4614f95ae1cab28b0686048
Publikováno v:
EXCLI Journal : Experimental and Clinical Sciences, Vol 22, Pp 1113-1128 (2023)
The virus interacts with its hosts by developing protein-protein interactions. Most viruses employ protein interactions to imitate the host protein: A viral protein with the same amino acid sequence or structure as the host protein attaches to the ho
Externí odkaz:
https://doaj.org/article/889fbb57f3ae45ffb5868c98d851a0e7
Autor:
Tomalika R. Ullah, Matt D. Johansen, Katherine R. Balka, Rebecca L. Ambrose, Linden J. Gearing, James Roest, Julian P. Vivian, Sunil Sapkota, W. Samantha N. Jayasekara, Daniel S. Wenholz, Vina R. Aldilla, Jun Zeng, Stefan Miemczyk, Duc H. Nguyen, Nicole G. Hansbro, Rajan Venkatraman, Jung Hee Kang, Ee Shan Pang, Belinda J. Thomas, Arwaf S. Alharbi, Refaya Rezwan, Meredith O’Keeffe, William A. Donald, Julia I. Ellyard, Wilson Wong, Naresh Kumar, Benjamin T. Kile, Carola G. Vinuesa, Graham E. Kelly, Olivier F. Laczka, Philip M. Hansbro, Dominic De Nardo, Michael P. Gantier
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract TANK-binding kinase 1 (TBK1) is a key signalling component in the production of type-I interferons, which have essential antiviral activities, including against SARS-CoV-2. TBK1, and its homologue IκB kinase-ε (IKKε), can also induce pro-
Externí odkaz:
https://doaj.org/article/780fdb67fa074e35823aa88357231e9d
Autor:
Nafeesa Shahdab, Christopher Ward, Philip M. Hansbro, Stephen Cummings, John S. Young, Fatemeh Moheimani
Publikováno v:
Cells, Vol 13, Iss 11, p 919 (2024)
Respiratory viruses cause airway inflammation, resulting in epithelial injury and repair. miRNAs, including miR-149-5p, regulate different pathological conditions. We aimed to determine how miR-149-5p functions in regulating pro-inflammatory IL-6 and
Externí odkaz:
https://doaj.org/article/5fc962425758432fb358ec299d27c013
Autor:
Nikhil T. Awatade, Andrew T. Reid, Kristy S. Nichol, Kurtis F. Budden, Punnam Chander Veerati, Prabuddha S. Pathinayake, Christopher L. Grainge, Philip M. Hansbro, Peter A. B. Wark
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Primary air liquid interface (ALI) cultures of bronchial epithelial cells are used extensively to model airway responses. A recent advance is the development of conditional reprogramming that enhances proliferative capability. Several differ
Externí odkaz:
https://doaj.org/article/34e398b88c08484c9891f298e967ba74
Autor:
Tristram A. J. Ryan, Alexander Hooftman, Aisling M. Rehill, Matt D. Johansen, Eóin C. O’ Brien, Juliana E. Toller-Kawahisa, Mieszko M. Wilk, Emily A. Day, Hauke J. Weiss, Pourya Sarvari, Emilio G. Vozza, Fabian Schramm, Christian G. Peace, Alessia Zotta, Stefan Miemczyk, Christina Nalkurthi, Nicole G. Hansbro, Gavin McManus, Laura O’Doherty, Siobhan Gargan, Aideen Long, Jean Dunne, Clíona Ní Cheallaigh, Niall Conlon, Michael Carty, Padraic G. Fallon, Kingston H. G. Mills, Emma M. Creagh, James S. O’ Donnell, Paul J. Hertzog, Philip M. Hansbro, Rachel M. McLoughlin, Małgorzata Wygrecka, Roger J. S. Preston, Zbigniew Zasłona, Luke A. J. O’Neill
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Excessive inflammation-associated coagulation is a feature of infectious diseases, occurring in such conditions as bacterial sepsis and COVID-19. It can lead to disseminated intravascular coagulation, one of the leading causes of mortality w
Externí odkaz:
https://doaj.org/article/0df3d79819534a4786cd65226889c413
Autor:
Viviani Mendes de Almeida, Daiane F. Engel, Mayra F. Ricci, Clênio Silva Cruz, Ícaro Santos Lopes, Daniele Almeida Alves, Mirna d’ Auriol, João Magalhães, Elayne C. Machado, Victor M. Rocha, Toniana G. Carvalho, Larisse S. B. Lacerda, Jordane C. Pimenta, Mariana Aganetti, Giuliana S. Zuccoli, Bradley J. Smith, Victor C. Carregari, Erika da Silva Rosa, Izabela Galvão, Geovanni Dantas Cassali, Cristiana C. Garcia, Mauro Martins Teixeira, Leiliane C. André, Fabiola Mara Ribeiro, Flaviano S. Martins, Rafael Simone Saia, Vivian Vasconcelos Costa, Daniel Martins-de-Souza, Philip M. Hansbro, João Trindade Marques, Eric R. G. R. Aguiar, Angélica T. Vieira
Publikováno v:
Gut Microbes, Vol 15, Iss 2 (2023)
ABSTRACTLong-term sequelae of coronavirus disease (COVID)-19 are frequent and of major concern. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection affects the host gut microbiota, which is linked to disease severity in patients wi
Externí odkaz:
https://doaj.org/article/06aebb87d65248389910158a7d32fbcb
Autor:
Jason L. N. Girkin, Leon A. Sokulsky, Malcolm R. Starkey, Philip M. Hansbro, Paul S. Foster, Adam M. Collison, Joerg Mattes
Publikováno v:
Frontiers in Allergy, Vol 4 (2023)
IntroductionEosinophilic esophagitis (EoE) is associated with allergen-driven inflammation of the esophagus and an upregulated Th2 cytokine signature. Recombinant interleukin (IL)-13 (rIL-13) administration to mice induces some of the hallmark featur
Externí odkaz:
https://doaj.org/article/41fd15d331eb4189b86c5a818ebf3301
Autor:
Gaetano Scaramuzzo, Francesco Nucera, Alessio Asmundo, Roberto Messina, Matilde Mari, Federica Montanaro, Matt D. Johansen, Francesco Monaco, Guido Fadda, Giovanni Tuccari, Nicole G. Hansbro, Philip M. Hansbro, Trevor T. Hansel, Ian M. Adcock, Antonio David, Paul Kirkham, Gaetano Caramori, Carlo Alberto Volta, Savino Spadaro
Publikováno v:
Journal of Inflammation, Vol 20, Iss 1, Pp 1-24 (2023)
Abstract The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection can be asymptomatic or cause a disease (COVID-19) characterized by different levels of severity. The main cause of severe COVID-19 and death is represented by acute (
Externí odkaz:
https://doaj.org/article/09db15bec1ab49ba975346d548e55894