Výsledky vyhledávání - "Philip M Toleikis"

Akademický článek

Subcutaneous transplantation of human thyroid tissue into a pre-vascularized Cell Pouch™ device in a Mus musculus model: Evidence of viability and function for thyroid transplantation.

Autor: Sam M Wiseman, Arash Memarnejadian, Guilaine K Boyce, Anne Nguyen, Blair A Walker, Daniel T Holmes, Ian D Welch, Delfina M Mazzuca, Philip M Toleikis

Publikováno v: PLoS ONE, Vol 17, Iss 1, p e0262345 (2022)

This study aimed to investigate the survival and efficacy indicators of human thyroid tissue transplantation into a retrievable, prevascularized implanted Sernova Corp Cell Pouch™ (CP) device. Thyroid tissue from human donors was transplanted subcu

Externí odkaz: https://doaj.org/article/d6891358bae74b9e889b29139523cac9

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Efficient and safe correction of hemophilia A by lentiviral vector-transduced BOECs in an implantable device

Publikováno v: Molecular Therapy-Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss, Pp 551-566 (2021)
Molecular Therapy. Methods & Clinical Development

Hemophilia A (HA) is a rare bleeding disorder caused by deficiency/dysfunction of the FVIII protein. As current therapies based on frequent FVIII infusions are not a definitive cure, long-term expression of FVIII in endothelial cells through lentivir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2ff8cd4584a8b2d9e58d1ea9112e85b

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205-LB: Clinical Validation of the Implanted Prevascularized Cell Pouch as a Viable, Safe Site for Diabetes Cell Therapy

Autor: Philip M. Toleikis, A. MacGillivary, Delfina M. Mazzuca

Publikováno v: Diabetes. 69

We report current clinical findings for the Cell Pouch (CP), as an implantable and retrievable medical device designed to develop a healthy vascularized tissue environment for transplantation and engraftment of therapeutic cells, which release the de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6bcfd190c7f12f034fb1f008c3180edf
https://doi.org/10.2337/db20-205-lb

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Diabetes Is Reversed in a Murine Model by Marginal Mass Syngeneic Islet Transplantation Using a Subcutaneous Cell Pouch Device

Autor: Rena Pawlick, A. MacGillivary, Boris Gala-Lopez, Philip M. Toleikis, David J. G. White, A. M. James Shapiro, Delfina M. Mazzuca, Andrew R. Pepper

Publikováno v: Transplantation

Background Islet transplantation is a successful β-cell replacement therapy for selected patients with type 1 diabetes mellitus. Although high rates of early insulin independence are achieved routinely, long-term function wanes over time. Intraporta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfc4bcb1638b398460ebb45f6e67ff71
https://doi.org/10.1097/tp.0000000000000864

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A novel technique for the transplantation of pancreatic islets within a vascularized device into the greater omentum to achieve insulin independence

Autor: Philip M. Toleikis, Delfina M. Mazzuca, David J.G. White, Paula J. Foster, Jan Kriz, Greg Vilk

Publikováno v: The American Journal of Surgery. 203:793-797

Background The greater omentum with its vascularization and blood flow has been considered as a location for islet transplantation; however, there is a need to provide a controlled and protected site for the islets within the omentum that would be ap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::add57f872c2e3d7841346060dcb276a3
https://doi.org/10.1016/j.amjsurg.2011.02.009

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Intrapericardial Paclitaxel Delivery Inhibits Neointimal Proliferation and Promotes Arterial Enlargement After Porcine Coronary Overstretch

Autor: William L. Hunter, Keith L. March, Philip M. Toleikis, Pamela I. Rogers, Dongming Hou

Publikováno v: Circulation. 102:1575-1581

Background —Catheter-based intrapericardial (IPC) delivery of therapeutic agents has recently been demonstrated. Paclitaxel is known to inhibit vascular smooth muscle cell proliferation. This study examined the effect of IPC instillation of paclita

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1acf030b78894da3357ef33d5619ae66
https://doi.org/10.1161/01.cir.102.13.1575

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Development of copolymers of poly(d,l-lactide) and methoxypolyethylene glycol as micellar carriers of paclitaxel

Autor: Helen M. Burt, William L. Hunter, Philip M. Toleikis, Xichen Zhang, Leanne Embree

Publikováno v: Colloids and Surfaces B: Biointerfaces. 16:161-171

Diblock copolymers containing one block of methoxypolyethylene glycol (MePEG) and one block of either poly( d , l -lactide) (PDLLA), copolymers of poly( d , l -lactide-co-caprolactone) (PDLLACL) or poly(glycolide-co-caprolactone) (PGACL) were synthes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec93faad9b7a34a2b55212870220ab3f
https://doi.org/10.1016/s0927-7765(99)00067-3

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Alteration of antioxidant status following sympathectomy: Differential effects of modified plasma levels of adrenaline and noradrenaline

Autor: David V. Godin, Philip M. Toleikis

Publikováno v: Molecular and Cellular Biochemistry. 152:39-49

The influence of altered levels of endogenous catecholamines following adrenalectomy or 6-hydroxydopamine (6-OH) treatment (alone or in combination) on enzymatic (glutathione reductase, catalase, glutathione peroxidase and Cu,Zn superoxide dismutase)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f96ee0e9c2b96a2bfa65078f48d67a6
https://doi.org/10.1007/bf01076462

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Inhibition of neointimal hyperplasia in a sheep model of dialysis access failure with the bioabsorbable Vascular Wrap paclitaxel-eluting mesh

Autor: Ted R, Kohler, Philip M, Toleikis, David M, Gravett, Rui L, Avelar

Publikováno v: Journal of vascular surgery. 45(5)

This study evaluated the effect of a bioabsorbable mesh containing paclitaxel on neointimal hyperplasia in a sheep model of dialysis access failure.Forty neutered male sheep were randomized to one of five parallel groups: no mesh; or a 3-cm x 6-cm me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6b2245f0a5b22e3bf4aece25abc82b4d
https://pubmed.ncbi.nlm.nih.gov/17466798

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Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model

Autor: Sharon X. Xie, John Q. Trojanowski, Jennifer Bruce, Virginia M.-Y. Lee, Sonali Joyce, Chi Li, Sharon Shively, Bin Zhang, Arpita Maiti, Philip M. Toleikis, Fara Lakhani, Edward B. Lee, Gaye Mcdonald-Jones

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 102(1)

We tested the hypothesis that microtubule (MT)-binding drugs could be therapeutically beneficial in tauopathies by functionally substituting for the MT-binding protein tau, which is sequestered into inclusions of human tauopathies and transgenic mous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6657cbed35e1e7e683df65b0bf3b466
https://pubmed.ncbi.nlm.nih.gov/15615853

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