Zobrazeno 1 - 10
of 216
pro vyhledávání: '"Philip M Hopkins"'
Autor:
Philip M. Hopkins
Publikováno v:
BJA Open, Vol 9, Iss , Pp 100257- (2024)
Externí odkaz:
https://doaj.org/article/149fbd21ba1049c980c04a6235be5a9f
Autor:
Leon Chang, Rebecca Motley, Catherine L. Daly, Christine P. Diggle, Philip M. Hopkins, Marie-Anne Shaw
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 6, p 3489 (2024)
Malignant hyperthermia (MH) is a pharmacogenetic condition of skeletal muscle that manifests in hypermetabolic responses upon exposure to volatile anaesthetics. This condition is caused primarily by pathogenic variants in the calcium-release channel
Externí odkaz:
https://doaj.org/article/28d0a5a5009b474ba73677aa8ded28f8
Autor:
Leon Chang, Lois Gardner, Carol House, Catherine Daly, Adrian Allsopp, Daniel Roiz de Sa, Marie-Anne Shaw, Philip M. Hopkins
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 22, p 16124 (2023)
Exertional heat illness (EHI) is an occupational health hazard for athletes and military personnel–characterised by the inability to thermoregulate during exercise. The ability to thermoregulate can be studied using a standardised heat tolerance te
Externí odkaz:
https://doaj.org/article/0e758ad709d24e6799f6a7f63a8654c1
Autor:
Yukari Endo, Linda Groom, Alper Celik, Natalia Kraeva, Chang Seok Lee, Sung Yun Jung, Lois Gardner, Marie-Anne Shaw, Susan L. Hamilton, Philip M. Hopkins, Robert T. Dirksen, Sheila Riazi, James J. Dowling
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The genetic cause(s) of malignant hyperthermia and exertional heat illness are unknown in approximately 30% of cases. To address this barrier, the authors performed genome sequencing on a large cohort of cases, identifying rare variants in ASPH, a ge
Externí odkaz:
https://doaj.org/article/0f7dda93f47146bdbbcd6f5b2e4e2f5d
Autor:
Philip M. Hopkins
Publikováno v:
BJA Open, Vol 1, Iss , Pp 100001- (2022)
Summary: BJA Open is a new open access journal to complement British Journal of Anaesthesia. This editorial describes the rationale for the journal and the breadth of content it is seeking to attract. As with other BJA titles, BJA Open conforms to th
Externí odkaz:
https://doaj.org/article/a0ba9c2c91654b78a7651979ba441862
Autor:
Luuk R. van den Bersselaar, Luc Heytens, Helga C. A. Silva, Jens Reimann, Giorgio Tasca, Óscar Díaz‐Cambronero, Nicoline Løkken, Anna Hellblom, Philip M. Hopkins, Henrik Rueffert, Börge Bastian, Juan Jesus Vilchez, Robyn Gillies, Stephan Johannsen, Francis Veyckemans, Tino Muenster, Andrea Klein, Ron Litman, Heinz Jungbluth, Sheila Riazi, Nicol C. Voermans, Marc M. J. Snoeck
Publikováno v:
European Journal of Neurology, 29, 3486-3507
European journal of neurology
European Journal of Neurology, 29, 12, pp. 3486-3507
European journal of neurology
European Journal of Neurology, 29, 12, pp. 3486-3507
Contains fulltext : 287509.pdf (Publisher’s version ) (Open Access) BACKGROUND AND PURPOSE: Patients with neuromuscular conditions are at increased risk of suffering perioperative complications related to anaesthesia. There is currently little spec
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 5, Pp 1451-1461 (2017)
Delaying the decline in skeletal muscle function will be critical to better maintenance of an active lifestyle in old age. The skeletal muscle ryanodine receptor, the major intracellular membrane channel through which calcium ions pass to elicit musc
Externí odkaz:
https://doaj.org/article/342e95e473084d29af3a27c27d81c27d
Publikováno v:
British Journal of Anaesthesia. 128:7-10
Summary Gonzalez-Estrada and colleagues report an estimated risk of severe or fatal perioperative anaphylaxis of one in 6,825 procedures during the period 2005–2014. This is slightly higher than that reported previously in France and England. Sever
Publikováno v:
BJA Educ
Autor:
Ruth White, Anja H. Schiemann, Sophie M. Burling, Andrew Bjorksten, Terasa Bulger, Robyn Gillies, Philip M. Hopkins, Erik-Jan Kamsteeg, Roslyn G. Machon, Sean Massey, Dorota Miller, Margaret Perry, Marc M.J. Snoeck, Jeremy Stephens, Neil Street, Luuk R. van den Bersselaar, Kathryn M. Stowell
Publikováno v:
British journal of anaesthesia. 129(6)
A major bottleneck to the introduction of noninvasive presymptomatic diagnostic tests for the pharmacogenetic disorder malignant hyperthermia is the lack of functional data for associated variants.We screened 50 genes having a potential role in skele