Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Philip M Hemken"'
Autor:
Bryan C Tieman, Stephen Kovacs, Mary A Rodgers, Aurash Mohaimani, Svetoslava Gregory, David Christensen, Jeffrey A Moore, Lici Schurig-Briccio, James Hartnett, Alak Kar, Aaron Leeman, Angel Palmer, Lauren Rogers, Brian Dragoo, Steven Muszynski, Deborah Noblesmith, Samantha Gardner, Abigail Snipe-Bushey, Anna Kill, Xinxin Luo, Sneha Cherukuri, Tracey Rae, Christopher C Marohnic, Gavin A Cloherty, Anthony Scott Muerhoff, Philip M Hemken
Publikováno v:
BioTechniques, Vol 73, Iss 3, Pp 136-141 (2022)
Mutations in the nucleocapsid of SARS-CoV-2 may interfere with antigen detection by diagnostic tests. We used several methods to evaluate the effect of various SARS-CoV-2 nucleocapsid mutations on the performance of the Panbio™ and BinaxNOW™ late
Externí odkaz:
https://doaj.org/article/a1a5c21d6cb1492c89bd3b4de84b97b2
Publikováno v:
BioTechniques, Vol 71, Iss 1, Pp 370-375 (2021)
Inactivation of SARS-CoV-2 virus is necessary to mitigate risk but may interfere with diagnostic assay performance. We examined the effect of heat inactivation on a prototype SARS-CoV-2 antigen immunoassay run on the ARCHITECT automated analyzer. Rec
Externí odkaz:
https://doaj.org/article/40f7bdfbc1884c39a5226534dfc0d885
Autor:
Philip M. Hemken, Eitan Israeli, Russell Taylor, Chris Jacobson, Maria Datwyler, Rene Geissler, Abbas Hadji, Nicolette Jeanblanc, Kinnari Pandya, Marilee Marcinkus, Ryan Piktel, M. Felicia Bogdan, Mary Rodgers, Mark Anderson, Robert Ziemann, Bryan C. Tieman, David Hawksworth, Jeffrey Moore, Kathy S. Otis, Christopher C. Marohnic, Josie Corby, Bailin Tu, Zhihong Lin, Alak Kar, James Hartnett, Carolyn Strobel, Svetoslava Gregory, Tracey Rae, A. Scott Muerhoff, Susan Brophy, John R. Hackett, David Daghfal, Matthew L. Faron, Amorina Cruz, Phaedre Mohr, Lori Sokoll, Gerard J. Davis
Publikováno v:
Clinical Chemistry and Laboratory Medicine (CCLM).
Objectives To evaluate pre-analytical challenges related to high-volume central laboratory SARS-CoV-2 antigen testing with a prototype qualitative SARS-CoV-2 antigen immunoassay run on the automated Abbott ARCHITECT instrument. Methods Contrived posi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ef77c7cbcadb3bc22d74725735a8a3d
https://doi.org/10.1515/cclm-2022-1292
https://doi.org/10.1515/cclm-2022-1292
Publikováno v:
Biotechniques
Inactivation of SARS-CoV-2 virus is necessary to mitigate risk but may interfere with diagnostic assay performance. We examined the effect of heat inactivation on a prototype SARS-CoV-2 antigen immunoassay run on the ARCHITECT automated analyzer. Rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb3562c526adbe6056c4d4808e3cdf9
https://pubmed.ncbi.nlm.nih.gov/34139879
https://pubmed.ncbi.nlm.nih.gov/34139879
Autor:
Eitan, Israeli, Hideaki, Okura, Barry, Kreutz, Ryan, Piktel, Abbas, Hadji, Bailin, Tu, Zhihong, Lin, David J, Hawksworth, Bryan C, Tieman, Carolyn J, Strobel, Robert, Ziemann, Thomas P, Leary, A Scott, Muerhoff, Philip M, Hemken
Publikováno v:
Journal of Immunological Methods. 504:113262
Quantitative detection of interleukin-6 (IL-6) in serum and plasma can help monitor immune responses and the development of acute inflammation to guide patient management. We developed an IL-6 immunoassay for use with the automated ARCHITECT system f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b79ab0de901da218fc9eb50adf02769
https://doi.org/10.1016/j.jim.2022.113262
https://doi.org/10.1016/j.jim.2022.113262
Autor:
Ziding Feng, Philip M. Hemken, Lori J. Sokoll, Jorge A. Marrero, Susan H. Gawel, Michael Lucht, Sudhir Srivastava, Jianliang Dai, Xiaoqing Yang, Daniel W. Chan, Debra J. Elliott, Gerard J. Davis
Publikováno v:
Clinical Proteomics
Clinical Proteomics, Vol 16, Iss 1, Pp 1-9 (2019)
Clinical Proteomics, Vol 16, Iss 1, Pp 1-9 (2019)
Background The biomarkers alpha-fetoprotein (AFP) and protein induced by vitamin K absence/antagonist-II (PIVKA-II) may be useful for detecting early-stage hepatocellular carcinoma (HCC). We evaluated the performance of AFP and PIVKA-II levels, alone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb01ee6f59a0d5ba3e3066ce6e5bb287
https://pubmed.ncbi.nlm.nih.gov/30675135
https://pubmed.ncbi.nlm.nih.gov/30675135
Autor:
Gerard J. Davis, Reena Varkey, Ethan Grant, Meina Liang, Susan Brophy, Lydia Greenlees, Koustubh Ranade, Philip M. Hemken, T. Scott Manetz, Maria J. Datwyler, Nicolette M. Jeanblanc, Katie Streicher, Partha S. Chowdhury, Rozanne Lee
Publikováno v:
Clinica chimica acta; international journal of clinical chemistry. 464
Periostin is being investigated as a potential biomarker for T-helper-2 (Th2)-driven asthma or eosinophilic inflammation and may help to identify patients more likely to benefit from interleukin-13-targeted treatments. We report the development and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75dc7f4cc1d77b72efd16a0e8f9c8256
https://pubmed.ncbi.nlm.nih.gov/27751727
https://pubmed.ncbi.nlm.nih.gov/27751727
Autor:
Moacyr Ribeiro de Oliveira, D. Ross Camidge, Elizabeth Litvinovich, Yi-Lin Chiu, Cathy E. Nolan, Charles M. Rudin, Divis Khaira, Geoffrey I. Shapiro, Todd A. Busman, Hao Xiong, Caroline Dive, David R. Gandara, Evelyn McKeegan, Philip Bonomi, Sari H. Enschede, Rod A. Humerickhouse, Andrew Krivoshik, Leena Gandhi, Philip M. Hemken, Christine L. Hann
Publikováno v:
Journal of Clinical Oncology. 29:909-916
Purpose Resistance to chemotherapy-induced apoptosis represents a major obstacle to cancer control. Overexpression of Bcl-2 is seen in multiple tumor types and targeting Bcl-2 may provide therapeutic benefit. A phase I study of navitoclax, a novel in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc6f87e44478c89ed8bd41702d664196
https://doi.org/10.1200/jco.2010.31.6208
https://doi.org/10.1200/jco.2010.31.6208
Autor:
Rika Sekiya, Lori J. Sokoll, Barry L. Dowell, Kaori Morota, Philip M. Hemken, Masatoshi Nakagawa, Daniel W. Chan, Debra J. Elliott
Publikováno v:
Clinical chemistry and laboratory medicine. 49(4)
Background: Golgi protein-73 (GP73) and fucosylated proteins have been proposed as potential serum markers for liver disease and/or hepatocellular carcinoma (HCC). The purpose of this study was to compare the sensitivity and specificity of serum GP73
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::805ce5fd2881be1408fdd826d45ff737
https://pubmed.ncbi.nlm.nih.gov/21231906
https://pubmed.ncbi.nlm.nih.gov/21231906
Autor:
David R. Gandara, Philip Bonomi, Sari H. Enschede, Moacyr Ribeiro de Oliveira, Brenda Chyla, Barry L. Dowell, Leena Gandhi, Charles M. Rudin, Divis Khaira, Philip M. Hemken, Andrew Krivoshik, Rod A. Humerickhouse, Evelyn McKeegan, Elizabeth Litvinovich, Geoffrey I. Shapiro, D.R. Camidge
Publikováno v:
Cancer Research. 70:3738-3738
Background ABT-263 is a novel, BH3 mimetic that binds with high affinity (Ki≤1nM) and inhibits antiapoptotic Bcl2 family proteins. ABT-263 displays potent preclinical mechanism-based toxicity against SCLC cell lines. Pro-gastrin-releasing peptide (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e69e3c640a829e4b6aa9cb10baa5762b
https://doi.org/10.1158/1538-7445.am10-3738
https://doi.org/10.1158/1538-7445.am10-3738