Výsledky vyhledávání - "Philip M Driver"

Biomarkers: unrealized potential in sports doping analysis

Autor: Philip M Driver, Phil Teale, Chris Barton, Richard G. Kay

Publikováno v: Bioanalysis. 1:1103-1118

The fight against doping in sport using analytical chemistry is a mature area with a history of approximately 100 years in horse racing and at least 40 years in human sport. Over that period, the techniques used and the breadth of coverage have devel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b299451a6eb47fdb8c3cb6fa24e10460
https://doi.org/10.4155/bio.09.87

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Characterization of human trophoblast as a mineralocorticoid target tissue

Autor: Mark D. Kilby, Philip M Driver, Martin Hewison, Elizabeth A. Walker, Paul M. Stewart, Saaeha Rauz

Publikováno v: Molecular Human Reproduction. 9:793-798

In mineralocorticoid target tissues, 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) confers mineralocorticoid receptor selectivity by metabolizing hormonally active cortisol to inactive cortisone, allowing aldosterone access to the receptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b791d3aba1f33d646e3ea2844036eaf4
https://doi.org/10.1093/molehr/gag091

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Expression of 11beta-hydroxysteroid dehydrogenase isozymes and corticosteroid hormone receptors in primary cultures of human trophoblast and placental bed biopsies

Autor: Martin Hewison, Paul M. Stewart, Mark D. Kilby, Elizabeth A. Walker, Philip M Driver, Iwona J. Bujalska

Publikováno v: Molecular Human Reproduction. 7:357-363

Interconversion of active and inactive glucocorticoids, e.g. cortisol (F) and cortisone (E) is catalysed by 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) which exists as two isoforms. We have used human placental bed biopsies and an in-vitro cyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::311b606bfc99b2920ba04f6aea91e640
https://doi.org/10.1093/molehr/7.4.357

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Synergistic growth inhibition of prostate cancer cells by 1 alpha,25 Dihydroxyvitamin D(3) and its 19-nor-hexafluoride analogs in combination with either sodium butyrate or trichostatin A

Autor: Jasbir S. Moore, Moray J. Campbell, Ceri E Edwards, Geoffrey Brown, Jaqueline Engel, Milan R. Uskokovic, Philip M Driver, Samantha F Rashid, Elizabeth A. Walker

Publikováno v: Oncogene. 20(15)

Prostate cancer is a major cause of male cancer death. In vitro and in vivo data support a role for 1 alpha,25 Dihydroxyvitamin D(3) (1 alpha,25(OH)(2)D(3)) in regulating the growth and differentiation of the normal prostate gland yet prostate cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ad0971cff1852c4e6391b4eeef92f77
https://pubmed.ncbi.nlm.nih.gov/11313934

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