Výsledky vyhledávání - "Philip M Beart"

Akademický článek

Transcriptomic analysis and 3D bioengineering of astrocytes indicate ROCK inhibition produces cytotrophic astrogliosis

Autor: Ross D O'Shea, Chew L Lau, Natasha B Zulaziz, Francesca L Maclean, David R Nisbet, Malcolm K Horne, Philip M Beart

Publikováno v: Frontiers in Neuroscience, Vol 9 (2015)

Astrocytes provide trophic, structural and metabolic support to neurons, and are considered genuine targets in regenerative neurobiology, as their phenotype arbitrates brain integrity during injury. Inhibitors of Rho kinase (ROCK) cause stellation of

Externí odkaz: https://doaj.org/article/445f12325afc48fc9c7ed1903f88c828

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SLC1 family of amino acid transporters in GtoPdb v.2023.1

Autor: Philip M. Beart

Publikováno v: IUPHAR/BPS Guide to Pharmacology CITE. 2023

The SLC1 family of sodium dependent transporters includes the plasma membrane located glutamate transporters and the neutral amino acid transporters ASCT1 and ASCT2 [3, 52, 39, 40, 9].

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::94d702ef6b386d2e7238cd09f81653b6
https://doi.org/10.2218/gtopdb/f139/2023.1

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Leslie Iversen (1937–2020)

Autor: Bevyn Jarrott, Philip M Beart, Solomon H. Snyder, Anthony J. Turner

Publikováno v: Journal of Neurochemistry. 155:345-347

This is an Obituary for Leslie Iversen (1937-2020). Les Iversen was an internationally renowned neuroscientist and pharmacologist, a substantial contributor to university life, learned societies, the pharmaceutical industry and society at large. He d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7038eb729125217508e4e918cf9ecd7c
https://doi.org/10.1111/jnc.15163

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The origins and early history of neurochemistry and its societies

Autor: Philip M Beart, Anthony J. Turner, Graham A.R. Johnston, Anne I. Boullerne, Paul Foley

Publikováno v: Journal of Neurochemistry. 152:8-28

At the 2017 joint meeting of the International Society for Neurochemistry (ISN) and the European Society for Neurochemistry, 150 years of neurochemistry - the 50th anniversary of ISN, 40 years of European Society for Neurochemistry, and 60 years of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc03432fa80f22586646675beb6045b6
https://doi.org/10.1111/jnc.14839

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Amyotrophic Lateral Sclerosis and Autophagy: Dysfunction and Therapeutic Targeting

Autor: Philip M Beart, Bradley J. Turner, Azin Amin, Fazel Shabanpoor, Nirma D Perera

Publikováno v: Cells, Vol 9, Iss 2413, p 2413 (2020)
Cells

Over the past 20 years, there has been a drastically increased understanding of the genetic basis of Amyotrophic Lateral Sclerosis. Despite the identification of more than 40 different ALS-causing mutations, the accumulation of neurotoxic misfolded p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d0d807ed6b0468e9b5e2497024ad98
https://www.mdpi.com/2073-4409/9/11/2413

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Galactose-functionalised PCL nanofibre scaffolds to attenuate inflammatory action of astrocytes in vitro and in vivo

Autor: Sam Ozergun, Philip M Beart, Cecilia Cederfur, Ross D O'Shea, Jason J. Wang, Kevin E. Healy, Chew L. Lau, Doris Tomas, David R. Nisbet, Francesca L Maclean, Frederick R. Walker, Malcolm K. Horne

Publikováno v: Journal of materials chemistry. B. 5(22)

Astrocytes represent an attractive therapeutic target for the treatment of traumatic brain injury in the glial scar, which inhibits functional repair and recovery if persistent. Many biomaterial systems have been investigated for neural tissue engine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d0eb9bf486a3700cc92db7df4ce0733
https://pubmed.ncbi.nlm.nih.gov/32264140

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Mutant TDP-43 Expression Triggers TDP-43 Pathology and Cell Autonomous Effects on Primary Astrocytes: Implications for Non-cell Autonomous Pathology in ALS

Autor: Philip M Beart, Chew L. Lau, Mathew D. F. Chiam, Samantha K. Barton, Bradley J. Turner, Hakan Muyderman, Doris Tomas

Publikováno v: Neurochemical research. 45(6)

Motor neuron degeneration in amyotrophic lateral sclerosis (ALS) caused by mutations in superoxide dismutase 1 (SOD1) is partly non-cell autonomous, involving cellular dysfunction of astrocytes. Whether non-cell autonomous effects occur in other form

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34516e853405492b24f0876a58b234dc
https://pubmed.ncbi.nlm.nih.gov/32410044

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Autophagy in neurodegeneration: New insights underpinning therapy for neurological diseases

Autor: Angelo Poletti, Klas Blomgren, Philip M Beart, Olga Corti

Publikováno v: Journal of Neurochemistry
Journal of Neurochemistry, 2020, 154 (4), pp.354-371. ⟨10.1111/jnc.15002⟩
Journal of Neurochemistry, Wiley, 2020, 154 (4), pp.354-371. ⟨10.1111/jnc.15002⟩

International audience; In autophagy long-lived proteins, protein aggregates or damaged organelles are engulfed by vesicles called autophagosomes prior to lysosomal degradation. Autophagy dysfunction is a hallmark of several neurodegenerative disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64d2f5c1950cbb9470135142b57c17a8
https://hal.sorbonne-universite.fr/hal-02995411/document

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