Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Philip M, Kim"'
Publikováno v:
ACS Central Science, Vol 10, Iss 5, Pp 1001-1011 (2024)
Externí odkaz:
https://doaj.org/article/60c0919bafc34f9c8a66a15b2f043aa4
Autor:
Satra Nim, Darren M. O’Hara, Carles Corbi-Verge, Albert Perez-Riba, Kazuko Fujisawa, Minesh Kapadia, Hien Chau, Federica Albanese, Grishma Pawar, Mitchell L. De Snoo, Sophie G. Ngana, Jisun Kim, Omar M. A. El-Agnaf, Enrico Rennella, Lewis E. Kay, Suneil K. Kalia, Lorraine V. Kalia, Philip M. Kim
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Accumulation of α-synuclein into toxic oligomers or fibrils is implicated in dopaminergic neurodegeneration in Parkinson’s disease. Here we performed a high-throughput, proteome-wide peptide screen to identify protein-protein interaction
Externí odkaz:
https://doaj.org/article/5d9353322078445d81d882610543e049
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 4, p e1011033 (2023)
Protein design is a technique to engineer proteins by permuting amino acids in the sequence to obtain novel functionalities. However, exploring all possible combinations of amino acids is generally impossible due to the exponential growth of possibil
Externí odkaz:
https://doaj.org/article/d895d72c14004ca78d8615e2a4e97cf4
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
PepNN integrates an attention-based deep learning module with transfer learning to predict the peptide binding sites of input proteins and the binding ability of proteins lacking a known peptide ligand.
Externí odkaz:
https://doaj.org/article/b4a42e9b964c42ae8133d1c3679e5014
Autor:
Joan Teyra, Abdellali Kelil, Shobhit Jain, Mohamed Helmy, Raghav Jajodia, Yogesh Hooda, Jun Gu, Akshay A D’Cruz, Sandra E Nicholson, Jinrong Min, Marius Sudol, Philip M Kim, Gary D Bader, Sachdev S Sidhu
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 12, Pp 1-15 (2020)
Abstract Many proteins involved in signal transduction contain peptide recognition modules (PRMs) that recognize short linear motifs (SLiMs) within their interaction partners. Here, we used large‐scale peptide‐phage display methods to derive opti
Externí odkaz:
https://doaj.org/article/d19aa4af6b674dc78769d9a4bc13168c
Computational generation of proteins with predetermined three-dimensional shapes using ProteinSolver
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100505- (2021)
Summary: Computational generation of new proteins with a predetermined three-dimensional shape and computational optimization of existing proteins while maintaining their shape are challenging problems in structural biology. Here, we present a protoc
Externí odkaz:
https://doaj.org/article/04ad2d19700445e8b70f6a2cb971750a
Publikováno v:
Nature Computational Science. 3:382-392
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::473756d99556fe0f7a443ddd01e47684
https://doi.org/10.1038/s43588-023-00440-3
https://doi.org/10.1038/s43588-023-00440-3
Publikováno v:
Trends in Pharmacological Sciences. 44:175-189
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74e506a7dd79e6af8e2c1668783fb219
https://doi.org/10.1016/j.tips.2022.12.005
https://doi.org/10.1016/j.tips.2022.12.005
Autor:
Seong Jun Park, Sanggeun Song, Gil-Suk Yang, Philip M. Kim, Sangwoon Yoon, Ji-Hyun Kim, Jaeyoung Sung
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
A unified framework to understand gene expression noise is still lacking. Here the authors derive a universal theorem relating the biological noise with dynamics of birth and death processes and present a model of transcription dynamics, allowing ana
Externí odkaz:
https://doaj.org/article/453b0f4d9a3147b59f1f6680d93343c0
Non-base-contacting residues enable kaleidoscopic evolution of metazoan C2H2 zinc finger DNA binding
Autor:
Hamed S. Najafabadi, Michael Garton, Matthew T. Weirauch, Sanie Mnaimneh, Ally Yang, Philip M. Kim, Timothy R. Hughes
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-15 (2017)
Abstract Background The C2H2 zinc finger (C2H2-ZF) is the most numerous protein domain in many metazoans, but is not as frequent or diverse in other eukaryotes. The biochemical and evolutionary mechanisms that underlie the diversity of this DNA-bindi
Externí odkaz:
https://doaj.org/article/c8a9f244e20f4218a7bbfebe86e3bbdc