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pro vyhledávání: '"Philip Lee Sheridan"'
VSV-G Pseudotyped Lentiviral Vector Particles Produced in Human Cells Are Inactivated by Human Serum
Autor:
Philip Lee Sheridan, Nicholas J. DePolo, Sybille L. Sauter, Kay Townsend, Joyce D. Reed, Thomas W. Dubensky, Douglas J. Jolly
Publikováno v:
Molecular Therapy. 2:218-222
Lentiviral vectors transduce dividing and postmitotic cells and thus are being developed toward therapies for many diseases affecting diverse tissues. One essential requirement for efficacy will be that vector particles are resistant to inactivation
Autor:
James E. McCormack, Nancy Sajjadi, Thomas W. Dubensky, James G. Respess, Joanne O'Dea, Trung K. Phuong, Carlos E. Ibanez, Judith Greengard, Philip Lee Sheridan, Margaret Dow Moore, Daniel J. de la Vega, Sybille L. Sauter, Kay Townsend, Kathy Nguyen, David A. Driver, Douglas J. Jolly, Andrea Lynn, Nicholas J. DePolo, Mordechai Bodner, Stephen M. W. Chang
Publikováno v:
Molecular Therapy. 2(3):262-275
For many applications, human clinical therapies using retroviral vectors still require many technological improvements in key areas of vector design and production. These improvements include higher unprocessed manufacturing titers, complement-resist
Publikováno v:
Critical Reviews in Therapeutic Drug Carrier Systems. 17:60
In this review, we describe technical advancements of retroviral vectors to address issues of safety, titer, and clinical scale manufacturing to produce high-quality retroviral vector preparations that have made direct intratumoral administration of