Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Philip Lane"'
Autor:
Xin Yu Koh, Xiao Hui Koh, Diana Spiegelberg, Preeti Jha, Marika Nestor, Le-ann Hwang, Ban Xiong Tan, David Philip Lane
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract The RON receptor tyrosine kinase is an exceptionally interesting target in oncology and immunology. It is not only overexpressed in a wide variety of tumors but also has been shown to be expressed on myeloid cells associated with tumor infil
Externí odkaz:
https://doaj.org/article/7630592839b745e4807f205edee05a36
Autor:
Diana Spiegelberg, Anja Charlotte Lundgren Mortensen, Kartika Dyah Palupi, Patrick Micke, Julin Wong, Borivoj Vojtesek, David Philip Lane, Marika Nestor
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
RationalcMet is abnormally regulated in gastrointestinal cancer, and is associated with increased invasiveness of the disease and poor overall survival. There are indications that targeted therapy against cMet, alone or in combination with additional
Externí odkaz:
https://doaj.org/article/5432d99071b24b57adc1dde95164618e
Autor:
Anja Charlotte Lundgren Mortensen, Diana Spiegelberg, Christopher John Brown, David Philip Lane, Marika Nestor
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
The tumor suppressor p53 is a key mediator of cellular stress and DNA damage response cascades and is activated after exposure to ionizing radiation. Amplifying wild-type p53 expression by targeting negative regulators such as MDM2 in combination wit
Externí odkaz:
https://doaj.org/article/625d8ae824cf4fb8841b5f0c06ec12c1
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Many therapeutic antibodies are humanized from animal sources. In the humanization process, complementarity determining region grafting is tedious and highly prone to failure. With seven known VH families, and up to six known κ VL families, there ar
Externí odkaz:
https://doaj.org/article/40efb8e444af4b35a16b896538f29dc5
Autor:
Michael R. Toomey, Jeffrey P. Donnelly, Philip Lane, E. J. Wallace, Dana MacDonald, Jonathan D. Woodruff, J. R. Rodysill, Peter J. van Hengstum, K. McKeon, Nicole D'Entremont, Richard Sullivan, Andrea D. Hawkes
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Scientific Reports
Scientific Reports
Hurricane Michael (2018) was the first Category 5 storm on record to make landfall on the Florida panhandle since at least 1851 CE (Common Era), and it resulted in the loss of 59 lives and $25 billion in damages across the southeastern U.S. This even
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e08292815e0d88ed8e18d8c74dec2377
http://link.springer.com/article/10.1038/s41598-020-75874-0
http://link.springer.com/article/10.1038/s41598-020-75874-0
Autor:
Michael R. Toomey, D. Philip Lane, Dana MacDonald, Jeffrey P. Donnelly, Peter J. van Hengstum, Bryan N. Shuman, Jonathan D. Woodruff, Andrea D. Hawkes
Publikováno v:
Earth's Future. 3:49-65
How climate controls hurricane variability has critical implications for society is not well understood. In part, our understanding is hampered by the short and incomplete observational hurricane record. Here we present a synthesis of intense-hurrica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2db089d6714184a70c1d647582f79e5b
https://doi.org/10.1002/2014ef000274
https://doi.org/10.1002/2014ef000274
Autor:
Brian Kakuk, Peter J. van Hengstum, Michael R. Toomey, Philip Lane, Nancy A. Albury, Jeffrey P. Donnelly
Publikováno v:
Continental Shelf Research. 86:103-115
Deciphering how the climate system has controlled North Atlantic tropical cyclone activity through the Holocene will require a larger observational network of prehistoric hurricane activity. Problematically, the tropical North Atlantic is dominated b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5dd737755ac0b951f2dc63d75db524ea
https://doi.org/10.1016/j.csr.2013.04.032
https://doi.org/10.1016/j.csr.2013.04.032
Publikováno v:
Journal of Geophysical Research: Atmospheres. 119:8606-8623
Historical tropical cyclone (TC) and storm surge records are often too limited to quantify the risk to local populations. Paleohurricane sediment records uncover long-term TC activity, but interpreting these records can be difficult and can introduce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d39e8ea7185e0de43d711ea97ad1024c
https://doi.org/10.1002/2014jd021584
https://doi.org/10.1002/2014jd021584
Publikováno v:
Quantifying overwash flux in barrier systems : an example from Marthas Vineyard, Massachusetts, USA
Coastal barriers are particularly susceptible to the effects of accelerated sea-level rise and intense storms. Over centennial scales, barriers are maintained via overtopping during storms, which causes deposition of washover fans on their landward s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33f619fd55eb3576f2f1b2a9708e1b42
https://doi.org/10.1016/j.margeo.2013.05.013
https://doi.org/10.1016/j.margeo.2013.05.013
Publikováno v:
Geochemistry, Geophysics, Geosystems. 14:2993-3008
[1] Recent work suggests that the patterns of intense (≥category 3 on the Saffir-Simpson scale) hurricane strikes over the last few millennia might differ from that of overall hurricane activity during this period. Prior studies typically rely on a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64595886b6defd51f8bd59bf804728bb
https://doi.org/10.1002/ggge.20217
https://doi.org/10.1002/ggge.20217