Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Philip L. R. Gaskin"'
Autor:
Laith Alexander, Christian M. Wood, Philip L. R. Gaskin, Stephen J. Sawiak, Tim D. Fryer, Young T. Hong, Lauren McIver, Hannah F. Clarke, Angela C. Roberts
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Alexander et al. causally implicate over-activity in primate subgenual cingulate in affective and cardiovascular dysfunction relevant to anxiety and depression. Over-activation led to elevated activity in a stress-related network whilst decreasing ac
Externí odkaz:
https://doaj.org/article/c4882c5246f44a9f9ba8c63aa0cd943b
Autor:
Donavon McConn, Betty Lam, Victoria J Mulligan, Nicola Brice, Hans H Schiffer, Holger Monenschein, Stephen Hitchcock, Holly Reichard, Nidhi Kaushal, Deanna R Collia, Philip L R Gaskin, Jordi Serrats, Alejandro Amador-Arjona, William J. Ray, Jackie Cilia, Joshua Bliesath, Alton W Skaggs, Josephine Atienza, Gerard Corbett, Lisa Rahbaek
Publikováno v:
Journal of Medicinal Chemistry. 64:11527-11542
The orphan G-protein-coupled receptor GPR139 is highly expressed in the habenula, a small brain nucleus that has been linked to depression, schizophrenia (SCZ), and substance-use disorder. High-throughput screening and a medicinal chemistry structure
Autor:
Laith, Alexander, Philip L R, Gaskin, Stephen J, Sawiak, Tim D, Fryer, Young T, Hong, Gemma J, Cockcroft, Hannah F, Clarke, Angela C, Roberts
Publikováno v:
Neuron
Summary Anhedonia is a core symptom of depression, but the underlying neurobiological mechanisms are unknown. Correlative neuroimaging studies implicate dysfunction within ventromedial prefrontal cortex, but the causal roles of specific subregions re