Zobrazeno 1 - 10
of 38 703
pro vyhledávání: '"Philip L"'
Publikováno v:
BMC Nursing, Vol 23, Iss 1, Pp 1-8 (2024)
Abstract Aim To evaluate the experience and effectiveness of six semi-structured writing retreats on research publication quantity and quality for nursing and midwifery academics and research students. Background Research publications are necessary t
Externí odkaz:
https://doaj.org/article/b9f9c974cab54bb2a6e2c7be7e21e9ec
Autor:
Qiang Chen, Luis Aguirre, Guoming Liang, Huanhuan Zhao, Tao Dong, Felix Borrego, Itziar de Rojas, Qichan Hu, Christopher Reyes, Ling-Yan Su, Bao Zhang, James D. Lechleiter, Harald H. H. Göring, Philip L. De Jager, Joel E. Kleinman, Thomas M. Hyde, Pan P. Li, Agustín Ruiz, Daniel R. Weinberger, Sudha Seshadri, Liang Ma
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-18 (2024)
Abstract Background The APOE gene is the strongest genetic risk factor for late-onset Alzheimer’s Disease (LOAD). However, the gene regulatory mechanisms at this locus remain incompletely characterized. Methods To identify novel AD-linked functiona
Externí odkaz:
https://doaj.org/article/5374844758ed40dc95d178d7f3ae89ee
Autor:
Randy L. Parrish, Aron S. Buchman, Shinya Tasaki, Yanling Wang, Denis Avey, Jishu Xu, Philip L. De Jager, David A. Bennett, Michael P. Epstein, Jingjing Yang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Multiple reference panels of a given tissue or multiple tissues often exist, and multiple regression methods could be used for training gene expression imputation models for transcriptome-wide association studies (TWAS). To leverage expressi
Externí odkaz:
https://doaj.org/article/e1438fafdf334bde867c5aecd9114757
Autor:
Joshua L. Bonkowsky, Bridget Healey, Naomi C. Sacks, Ronaé McLin, Philip L. Cyr, Eileen K. Sawyer, Christopher D. Stephen, Florian Eichler
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 19, Iss 1, Pp 1-11 (2024)
Abstract Background Adrenomyeloneuropathy (AMN) is a neurodegenerative disease phenotype of X-linked adrenoleukodystrophy (ALD), resulting in progressive myeloneuropathy causing spastic paraparesis, sensory ataxia, and bowel/bladder symptoms. We cond
Externí odkaz:
https://doaj.org/article/73291e113afa4a17b2063bcb446e2516
Single cell transcriptomes and multiscale networks from persons with and without Alzheimer’s disease
Autor:
Qi Wang, Jerry Antone, Eric Alsop, Rebecca Reiman, Cory Funk, Jaroslav Bendl, Joel T. Dudley, Winnie S. Liang, Timothy L. Karr, Panos Roussos, David A. Bennett, Philip L. De Jager, Geidy E. Serrano, Thomas G. Beach, Kendall Van Keuren-Jensen, Diego Mastroeni, Eric M. Reiman, Benjamin P. Readhead
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The emergence of single nucleus RNA sequencing (snRNA-seq) offers to revolutionize the study of Alzheimer’s disease (AD). Integration with complementary multiomics data such as genetics, proteomics and clinical data provides powerful oppor
Externí odkaz:
https://doaj.org/article/583e7a46c0434985a97259a70db5d4e3
Autor:
Jodi T. Thomas, Roger Huerlimann, Celia Schunter, Sue-Ann Watson, Philip L. Munday, Timothy Ravasi
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-21 (2024)
Abstract Background The nervous system is central to coordinating behavioural responses to environmental change, likely including ocean acidification (OA). However, a clear understanding of neurobiological responses to OA is lacking, especially for m
Externí odkaz:
https://doaj.org/article/bf04f5b2e6a248468ab3c87e02eff402
Autor:
Kaiming Tao, Zachary A. Osman, Philip L. Tzou, Soo-Yon Rhee, Vineet Ahluwalia, Robert W. Shafer
Publikováno v:
BMC Medical Research Methodology, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background Large language models (LLMs) that can efficiently screen and identify studies meeting specific criteria would streamline literature reviews. Additionally, those capable of extracting data from publications would enhance knowledge
Externí odkaz:
https://doaj.org/article/644a26d55740400eb9522b8dba4a1b4f
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-21 (2024)
Abstract Pain is rarely communicated alone, as it is often accompanied by emotions such as anger or sadness. Communicating these affective states involves shared representations. However, how an individual conceptually represents these combined state
Externí odkaz:
https://doaj.org/article/6e164c32ac004ae68ff0ad4868dc9084
Autor:
Shahram Oveisgharan, Lei Yu, Katia de Paiva Lopes, Vladislav A. Petyuk, Shinya Tasaki, Ricardo Vialle, Vilas Menon, Yanling Wang, Philip L. De Jager, Julie A. Schneider, David A. Bennett
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-9 (2024)
Abstract Accumulation of amyloid-β (Aβ) and tau tangles are hallmarks of Alzheimer’s disease. Aβ is extracellular while tau tangles are typically intracellular, and it is unknown how these two proteinopathies are connected. Here, we use data of
Externí odkaz:
https://doaj.org/article/db373cb64bd548c290a7761d99ec2353
Autor:
Elodie Saruco, Arnaud Saimpont, Franck Di Rienzo, Benjamin De Witte, Isabelle Laroyenne, Fanny Matéo, Marion Lapenderie, Sarah Goutte Solard, Isabelle Perretant, Charlotte Frenot, Philip L. Jackson, Aymeric Guillot
Publikováno v:
Journal of NeuroEngineering and Rehabilitation, Vol 21, Iss 1, Pp 1-12 (2024)
Abstract Background The therapeutic benefits of motor imagery (MI) are now well-established in different populations of persons suffering from central nervous system impairments. However, research on similar efficacy of MI interventions after amputat
Externí odkaz:
https://doaj.org/article/4085779c97d14642967043a3be825623