Targeted delivery of nerve growth factor to the cholinergic basal forebrain of Alzheimer’s disease patients: application of a second-generation encapsulated cell biodelivery device

Autor: Bengt Juliusson, Maria Eriksdotter, Ahmadul Kadir, Kaj Blennow, Inger Nennesmo, Lars Wahlberg, Göran Lind, Lars-Olof Wahlund, Åke Seiger, Erik Sundström, Philip Kusk, Agneta Nordberg, Per Almqvist, Taher Darreh-Shori, Bengt Linderoth, Daniel Ferreira, Helga Eyjolfsdottir, Niels Andreasen, Eric Westman, Maria Kristoffersen Wiberg, Azadeh Karami, Ove Almkvist, Anders Wall, Bengt Winblad

Publikováno v: Alzheimer's Research & Therapy

Background Targeted delivery of nerve growth factor (NGF) has emerged as a potential therapy for Alzheimer’s disease (AD) due to its regenerative effects on basal forebrain cholinergic neurons. This hypothesis has been tested in patients with AD us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::847e1719a8a2b367865bd3e4b1f40208
https://doi.org/10.1186/s13195-016-0195-9

Encapsulated Cell Biodelivery of Transposon-Mediated High-Dose NGF to the Göttingen Mini Pig Basal Forebrain

Autor: Carsten R. Bjarkam, Jens Christian Sørensen, Jens Tornøe, Bengt Juliusson, Lone Fjord-Larsen, Philip Kusk, Kaare S. Ettrup, Lars Wahlberg, Malene Torp

Publikováno v: The Open Tissue Engineering and Regenerative Medicine Journal. 5:35-42

Nerve Growth Factor (NGF) has therapeutic effects on the cholinergic neurodegeneration in Alzheimer's disease (AD). We have previously described an implantable Encapsulated Cell Biodelivery™ device, NsG0202, capable of local delivery of NGF to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8fd702dd876c50bdbea3e8eca092f080
https://doi.org/10.2174/1875043501205010035

Generation and properties of a new human ventral mesencephalic neural stem cell line

Autor: Bengt Juliusson, Philip Kusk, Ana Villa, Milagros Ramos, Morten Meyer, Isabel Liste, Alberto Martínez-Serrano, Elise T. Courtois, Emma G. Seiz

Publikováno v: Villa, A, Liste, I, Courtois, E T, Seiz, E G, Ramos, M, Meyer, M, Juliusson, B, Kusk, P & Martínez-Serrano, A 2009, ' Generation and properties of a new human ventral mesencephalic neural stem cell line ', Experimental Cell Research, vol. 315, no. 11, pp. 1860-74 . https://doi.org/10.1016/j.yexcr.2009.03.011

Udgivelsesdato: Jul-1 Neural stem cells (NSCs) are powerful research tools for the design and discovery of new approaches to cell therapy in neurodegenerative diseases like Parkinson's disease. Several epigenetic and genetic strategies have been test

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61dfbba97ed4642969a5faf40748dcd8
https://doi.org/10.1016/j.yexcr.2009.03.011

Encapsulated galanin-producing cells attenuate focal epileptic seizures in the hippocampus

Autor: Litsa Nikitidou, Philip Kusk, Lone Fjord-Larsen, Merab Kokaia, Malene Torp, Lars Wahlberg

Publikováno v: Epilepsia. 55(1)

Encapsulated cell biodelivery (ECB) is a relatively safe approach, since the devices can be removed in the event of adverse effects. The main objectives of the present study were to evaluate whether ECB could be a viable alternative of cell therapy f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::078d3de2fac7141cbc7eef19b07b331d
https://pubmed.ncbi.nlm.nih.gov/24245512

Purification and Stabilization of Transcriptionally Active Glucocorticoid Receptor

Autor: Barbour S. Warren, Ronald G. Wolford, Philip Kusk, Gordon L. Hager

Publikováno v: Journal of Biological Chemistry. 271:11434-11440

A major obstacle to the purification of glucocorticoid receptor (GR) is the very high nonspecific surface adsorption of this protein. This phenomenon is a property of the GR itself and does not reflect overall protein concentration or buffer conditio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a38711f8ee7cf71cfe9accf484f6634
https://doi.org/10.1074/jbc.271.19.11434